Noninvasive Thalamocortical Neuromodulation With Low-Intensity Focused Ultrasound for Persistent Developmental Stuttering

Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-65
SponsorUniversity of Michigan

About this trial

This research is studying the use of low-intensity focused ultrasound (LIFU; a mild, noninvasive acoustic stimulation technique) in a small number of people to learn about its safety as a treatment for stuttering. LIFU is a small, safe sound signal that produces a gentle, pulsing flow of acoustic waves to help different parts of the brain communicate with each other. Researchers want to understand how the mild, non-invasive brain stimulation affects speech relevant brain areas, which may in turn affect speech fluency and speaking-related brain activity in people who stutter.

Eligibility criteria

Qualifiers

have normal language, hearing and cognition

speak English as their primary language

currently stutter

score at least 10 (very mild) on the Stuttering Severity Instrument (SSI-4) or exhibit greater than 3% stuttered syllables during at least one of the first 3 speech samples

Disqualifiers

History of seizures

Major medical or neurological illness (e.g., stroke, serious head trauma, brain infection, Parkinson's disease, etc.)

History of closed head injury with loss of consciousness (e.g., concussion)

Metal or electronic implants such as cochlear implants and pacemakers

Trial design

Treatments tested in this trial

  • High DC LIFU
  • Sham

Treatment groups

20 Participants
are divided into 2 treatment groups

Sponsors and collaborators

University of Michigan

Lead sponsor

Michigan Pioneer Fellowship

Collaborator