[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100624037":3},{"organization":4,"armGroups":7,"interventions":7,"overallOfficials":7,"centralContacts":8,"locations":7,"responsibleParty":18,"collaborators":7,"id":22,"slug":7,"hasResults":23,"nctId":24,"briefTitle":25,"officialTitle":26,"acronym":27,"eligibilityCriteria":28,"healthyVolunteers":23,"sex":29,"minAge":30,"maxAge":31,"enrollmentInfo":32,"targetDuration":7,"studyType":35,"phases":7,"briefSummary":36,"conditions":37,"keywords":39,"overallStatus":52,"whyStopped":7,"lastUpdateSubmitDate":53,"lastUpdatePostDateStruct":54,"startDateStruct":57,"completionDateStruct":59,"leadSponsor":61,"locationsCount":7},{"fullName":5,"class":6},"University of Modena and Reggio Emilia","OTHER",null,[9,14],{"name":10,"role":11,"phone":12,"phoneExt":7,"email":13},"Roberto Tonelli, MD, PhD","CONTACT","0039059425934","rtonelli@unimore.it",{"name":15,"role":11,"phone":16,"phoneExt":7,"email":17},"Stefania Cerri, MD, PhD","00390594225335","stefania.cerri@unimore.it",{"type":19,"investigatorFullName":20,"investigatorTitle":21,"investigatorAffiliation":5,"oldNameTitle":7,"oldOrganization":7},"PRINCIPAL_INVESTIGATOR","Roberto Tonelli","MD, PhD","100624037",false,"NCT07404423","OPEN-IPF: Observational Prediction modEl for cliNical Outcomes in Idiopathic Pulmonary Fibrosis","Observational Prediction Model for Clinical Outcomes in Idiopathic Pulmonary Fibrosis: a Multicentre, ML-driven Study (OPEN-IPF)","OPEN-IPF","Inclusion Criteria:\n\n* Age ≥18 years\n* Diagnosis of idiopathic pulmonary fibrosis established according to international guidelines and local multidisciplinary team (MDT) assessment\n* Availability of baseline clinical and functional data\n* Availability of follow-up data for at least 12 months, or until a clinically relevant event (e.g., death, lung transplantation)\n\nExclusion Criteria:\n\n* Interstitial lung disease other than IPF\n* Lung transplantation performed before the baseline (index) date\n* Absence of any follow-up information after baseline","ALL","18 Years","90 Years",{"count":33,"type":34},1000,"ESTIMATED","OBSERVATIONAL","Idiopathic pulmonary fibrosis (IPF) is a progressive fibrotic lung disease with marked inter-individual heterogeneity in trajectories and outcomes. Despite antifibrotic therapies, reliable risk stratification in routine practice remains suboptimal. OPEN-IPF is a multicentre retrospective observational cohort study designed to build a harmonised real-world dataset across Italian IPF referral centres to enable the development and external validation of machine-learning (ML) models predicting clinically relevant outcomes.",[38],"Idiopathic Pulmonary Fibrosis",[40,41,42,43,44,45,46,47,48,49,50,51],"Idiopathic pulmonary fibrosis","IPF","Disease progression","Acute exacerbation","Antifibrotic therapy","Nintedanib","Pirfenidone","Real-world data","Machine learning","Prognostic model","External validation","Multicentre cohort","NOT_YET_RECRUITING","2026-02-04",{"date":55,"type":56},"2026-02-11","ACTUAL",{"date":58,"type":34},"2026-06-01",{"date":60,"type":34},"2027-06-01",{"name":5,"class":6}]