Opioid Misuse in Patients with Cancer

Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorRigshospitalet, Denmark

About this trial

The success of opioid treatment in terminally ill cancer patients set the stage for extending the same treatment principles to the treatment of all chronic pain conditions including chronic non-cancer pain and chronic pain in cancer, where survival and long-standing chronic disease trajectories are getting more prevalent due to increasing survival rates. In this context, opioid misuse as such has been highly neglected - especially in palliative care, but also in cancer pain management in general. Previous studies have explored the literature on opioid misuse among adult cancer patients, noting that the available evidence is still in its early stages. Limited prospective studies with a wide range of definitions and methodologies for assessing misuse exist. Therefore, it seems highly relevant and justified to study the prevalence of opioid misuse risk in patients with cancer. The hypothesis of this study is that opioid misuse is not uncommon in Danish patients in treatment with opioids for cancer-related pain. Thus, the prevalence of opioid misuse risk among patients with cancer in Danish palliative care units will be investigate.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Outpatients ≥ 18 years,

patients who are treated with opioids due to cancer-related pain.

Disqualifiers

Patients who do not master the Danish language in speech and writing,

Patients who have severe cognitive dysfunction,

Patients who are not treated with opioids,

Patients who refused to participate in the study.

Trial population

Patients will be recruited from Section of Palliative Medicine at Rigshospitalet. Patients can participate if ≥ 18 years and able to communicate in Danish.

Trial design

Design model

Other

Time perspective

Cross-sectional

Treatments tested in this trial

Not listed

Trial groups

No trial groups listed

Trial outcomes

Primary outcomes

1

Pain Medication Questionnaire (PMQ)

PMQ consists of 26 questions assesses the risk of opioid abuse in people with non-oncological chronic pain. The answers are given on a 5-point Likert scale. Total score varies between 0 and 104 points.

Time frame
Baseline
2

Opioid Risk Tool (ORT)

ORT consists of a 5-question screening instrument assessing the risk for opioid abuse among individuals prescribed opioids for treatment of chronic pain.

Time frame
Baseline

Secondary outcomes

1

Pain diagnosis

Categories: nociceptive somatic, nociceptive visceral, neuropathic, nociplastic, nociceptive +somatic (mixed).

Time frame
Baseline
2

Pain duration

In months.

Time frame
Baseline
3

Pain localization

Categories: head/face/mouth/neck, up limbs, lower limbs, thorax, abdomen, low back/gluteus/coccyx/pelvis.

Time frame
Baseline
4

Pain intensity

Numerical scale from 0 (no pain) to 10 (worst pain).

Time frame
Baseline

Other outcomes

1

Sex

Categories male, female.

Time frame
Baseline
2

Age

Complete years in number.

Time frame
Baseline
3

Marital status

Categories; single (unmarried), married, cohabitating, separated/divorced, widow/widower.

Time frame
Baseline
4

Education status

Categories, basic school, upper secondary or vocational school, higher education.

Time frame
Baseline

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