[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100588311":3},{"organization":4,"armGroups":7,"interventions":7,"overallOfficials":8,"centralContacts":13,"locations":22,"responsibleParty":143,"collaborators":145,"id":149,"slug":7,"hasResults":150,"nctId":151,"briefTitle":152,"officialTitle":152,"acronym":153,"eligibilityCriteria":154,"healthyVolunteers":150,"sex":155,"minAge":156,"maxAge":157,"enrollmentInfo":158,"targetDuration":161,"studyType":162,"phases":7,"briefSummary":163,"conditions":164,"keywords":7,"overallStatus":25,"whyStopped":7,"lastUpdateSubmitDate":167,"lastUpdatePostDateStruct":168,"startDateStruct":171,"completionDateStruct":173,"leadSponsor":175,"locationsCount":176},{"fullName":5,"class":6},"Inova Health Care Services","OTHER",null,[9],{"name":10,"affiliation":11,"role":12},"Palak Shah, MD","Inova Schar Heart and Vascular","PRINCIPAL_INVESTIGATOR",[14,18],{"name":10,"role":15,"phone":16,"phoneExt":7,"email":17},"CONTACT","(703) 776-8000","palak.shah@inova.org",{"name":19,"role":15,"phone":20,"phoneExt":7,"email":21},"Stephanie Wolak, MPH","571-472-8558","stephanie.wolak@inova.org",[23,43,58,75,91,107,123],{"facility":24,"status":25,"city":26,"state":27,"zip":28,"country":29,"countryCode":30,"cosmosGeoPoint":31,"geoPoint":36,"contacts":37},"Cedars-Sinai Medical Center","RECRUITING","Los Angeles","California","90048","United States","US",{"type":32,"coordinates":33},"Point",[34,35],-118.24368,34.05223,{"lat":35,"lon":34},[38,41],{"name":39,"role":15,"phone":7,"phoneExt":7,"email":40},"Lucilla Garcia","lucilla.garcia@csmns.org",{"name":42,"role":12,"phone":7,"phoneExt":7,"email":7},"Jon Kobashigawa, MD",{"facility":44,"status":25,"city":45,"state":27,"zip":46,"country":29,"countryCode":30,"cosmosGeoPoint":47,"geoPoint":51,"contacts":52},"Stanford University","Palo Alto","94304",{"type":32,"coordinates":48},[49,50],-122.14302,37.44188,{"lat":50,"lon":49},[53,56],{"name":54,"role":15,"phone":7,"phoneExt":7,"email":55},"James Pak","jamespak@stanford.edu",{"name":57,"role":12,"phone":7,"phoneExt":7,"email":7},"Kiran Khush, MD",{"facility":59,"status":25,"city":60,"state":61,"zip":62,"country":29,"countryCode":30,"cosmosGeoPoint":63,"geoPoint":67,"contacts":68},"Tufts Medical Center","Boston","Massachusetts","02111",{"type":32,"coordinates":64},[65,66],-71.05977,42.35843,{"lat":66,"lon":65},[69,73],{"name":70,"role":15,"phone":71,"phoneExt":7,"email":72},"Abena Adwetewa-Badu","617-636-9458","Abena.Adwetewa-Badu@tuftsmedicine.org",{"name":74,"role":12,"phone":7,"phoneExt":7,"email":7},"Jeong Hwan Kim, MD",{"facility":76,"status":25,"city":77,"state":78,"zip":79,"country":29,"countryCode":30,"cosmosGeoPoint":80,"geoPoint":84,"contacts":85},"Medical University of South Carolina","Charleston","South Carolina","29425",{"type":32,"coordinates":81},[82,83],-79.93275,32.77632,{"lat":83,"lon":82},[86,89],{"name":87,"role":15,"phone":7,"phoneExt":7,"email":88},"Melissa Amitrano","amitrano@musc.edu",{"name":90,"role":12,"phone":7,"phoneExt":7,"email":7},"Ryan Tedford, MD",{"facility":92,"status":25,"city":93,"state":94,"zip":95,"country":29,"countryCode":30,"cosmosGeoPoint":96,"geoPoint":100,"contacts":101},"Vanderbilt University","Nashville","Tennessee","37232",{"type":32,"coordinates":97},[98,99],-86.78444,36.16589,{"lat":99,"lon":98},[102,105],{"name":103,"role":15,"phone":7,"phoneExt":7,"email":104},"Lisa Slinger","Lisa.slinger@vumc.org",{"name":106,"role":12,"phone":7,"phoneExt":7,"email":7},"Kelly Schlendorf, MD",{"facility":108,"status":25,"city":109,"state":110,"zip":111,"country":29,"countryCode":30,"cosmosGeoPoint":112,"geoPoint":116,"contacts":117},"Baylor University Medical Center","Dallas","Texas","75246",{"type":32,"coordinates":113},[114,115],-96.80667,32.78306,{"lat":115,"lon":114},[118,121],{"name":119,"role":15,"phone":7,"phoneExt":7,"email":120},"Jasha Harvey","jasha.harvey@BSWHealth.org",{"name":122,"role":12,"phone":7,"phoneExt":7,"email":7},"Shelley Hall, MD",{"facility":124,"status":125,"city":126,"state":127,"zip":128,"country":29,"countryCode":30,"cosmosGeoPoint":129,"geoPoint":133,"contacts":134},"Inova Health System","NOT_YET_RECRUITING","Falls Church","Virginia","22042",{"type":32,"coordinates":130},[131,132],-77.17109,38.88233,{"lat":132,"lon":131},[135,139],{"name":136,"role":15,"phone":137,"phoneExt":7,"email":138},"Michaela Ramandanes, MPH","703-446-6466","michaela.ramandanes@inova.org",{"name":140,"role":15,"phone":141,"phoneExt":7,"email":142},"Jacqueline Fikry, MSHS","(703) 776-3966","Jacqueline.fikry@inova.org",{"type":144,"investigatorFullName":7,"investigatorTitle":7,"investigatorAffiliation":7,"oldNameTitle":7,"oldOrganization":7},"SPONSOR",[146],{"name":147,"class":148},"National Heart, Lung, and Blood Institute (NHLBI)","NIH","100588311",false,"NCT06939751","OPtimal Adult Heart Transplant Immunosuppression With MicroRNA Levels","OPTIMAL","Inclusion Criteria:\n\n* Age ≥ 18 years at enrollment\n* Receipt of orthotopic heart transplant (OHT) within the prior 1 month ± 2 weeks\n* Planned follow-up at the transplant center for a minimum of one-year.\n* Patient able and willing to comply with the study visit schedule, study procedures, and study requirements.\n\nExclusion Criteria:\n\n* Recipient of a multi-organ transplant\n* History of prior solid organ transplant before the index heart transplant\n* Ongoing mechanical circulatory support or hemodynamic instability (e.g., inotrope or vasopressor therapy)\n* Ongoing need for renal replacement therapy and\u002For dialysis\n* Active infection requiring either a) hospitalization b) treatment with antimicrobial therapy or c) reduction in immunosuppression\n* Active rejection being treated with intravenous medications or plasmapheresis","ALL","18 Years","99 Years",{"count":159,"type":160},250,"ESTIMATED","3 Years","OBSERVATIONAL","This study aims to develop and refine a microRNA (miR) biomarker panel that can be used to phenotype net immune state after heart transplantation using circulating miRs (associated with drug doses and levels). These miRs will be used to characterize the overall immune state in adult heart transplant patients and predict patients that will go on to develop infection and rejection. MicroRNAs (miRs) are small, non-coding RNA molecules that regulate gene expression and serve as molecular biomarkers found in the circulation.",[165,166],"Cardiac Failure","Graft Rejection","2026-04-20",{"date":169,"type":170},"2026-04-22","ACTUAL",{"date":172,"type":170},"2025-10-28",{"date":174,"type":160},"2032-01-01",{"name":5,"class":6},7]