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Optimizing Mango's Glycemic Impact: Investigating Mango Consumption Timing in Prediabetic Individuals

ConditionPre Diabetes
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age20-60
SponsorClinical Nutrition Research Center, Illinois Institute of Technology

About this trial

The purpose of this study is to investigate the effect of mango intake on metabolic and inflammatory responses relative to meals in individuals at risk of developing diabetes, as well as to understand how the beneficial compounds found in mangoes are absorbed and processed in the body.

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

Be between 20-60 years old.

Have a BMI of 25-35 kilograms per square meter.

Have fasting blood glucose between 100-125 milligrams per deciliter or Glycated hemoglobin (HbA1c) between 5.7-6.4%.

Be non-smokers for at least 12 months.

Disqualifiers

Smoke, vape, or use marijuana.

Have allergies or intolerance to mangoes or study foods.

Have blood pressure above 160/100 millimeters of Mercury.

Have fasting blood glucose above 125 milligrams per deciliter.

Trial design

Design model

Crossover

Treatments tested in this trial

  • Mango

    Other intervention

    Mango beverage

  • Control Beverage

    Other intervention

    Italian Ice beverage

Treatment groups

30 Participants
are divided into 4 treatment groups
Group A: Mango Before MealExperimental treatment 1 intervention
Group B: Mango With MealExperimental treatment 1 intervention
Group C: Mango After MealExperimental treatment 1 intervention
Group D: Control (no mango)Placebo comparator 1 intervention

Trial outcomes

Primary outcomes

1

Change in postprandial glucose

Change in postprandial glucose as measured by absolute values and calculated insulin sensitivity using homeostasis model assessment of fasting insulin sensitivity (HOMA-%S) and B-cell function (HOMA-%).

Time frame
7 hours
2

Change in postprandial glucose through peripheral insulin sensitivity

Change in postprandial glucose as measured by assessment of peripheral insulin sensitivity using Matsuda index.

Time frame
7 hours
3

Change in postprandial insulin

Change in postprandial insulin as measured by absolute values and calculated insulin sensitivity using homeostasis model assessment of fasting insulin sensitivity (HOMA-%S) and B-cell function (HOMA-%).

Time frame
7 hours
4

Change in postprandial insulin through peripheral insulin sensitivity

Change in postprandial insulin as measured by assessment of peripheral insulin sensitivity using Matsuda index.

Time frame
7 hours

Secondary outcomes

1

Characterize metabolite profiles

Polyphenolic metabolites (phenolic acids and derivatives components) will be identified and quantified in urine and plasma. Metabolites in samples will be identified and quantified using an Agilent 6550 iFunnel ultra-high performance liquid chromatography-quadrupole time-of-flight mass spectrometry (UHPLC/Q-TOF-MS) and 6460 ultra-high performance liquid chromatography- triple quadrupole mass spectrometry (UHPLC-QQQ-MS), respectively

Time frame
7 hours

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Clinical Nutrition Research Center, Illinois Institute of Technology

Lead sponsor

National Mango Board

Collaborator

Source ClinicalTrials.gov
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