[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100635951":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":30,"centralContacts":34,"locations":40,"responsibleParty":55,"collaborators":58,"id":62,"slug":25,"hasResults":63,"nctId":64,"briefTitle":65,"officialTitle":66,"acronym":67,"eligibilityCriteria":68,"healthyVolunteers":63,"sex":69,"minAge":70,"maxAge":71,"enrollmentInfo":72,"targetDuration":25,"studyType":75,"phases":76,"briefSummary":78,"conditions":79,"keywords":82,"overallStatus":91,"whyStopped":25,"lastUpdateSubmitDate":92,"lastUpdatePostDateStruct":93,"startDateStruct":96,"completionDateStruct":98,"leadSponsor":100,"locationsCount":101},{"fullName":5,"class":6},"Hung Vuong Hospital","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Conventional r-IVM","ACTIVE_COMPARATOR","Eligible GV oocytes are cultured for 24 hours in standard CSCMC medium under routine rescue in vitro maturation conditions without ovarian support cell co-culture.",[13],"Other: Conventional rescue in vitro maturation",{"label":15,"type":16,"description":17,"interventionNames":18},"r-IVM with iPSC-Derived OSC Co-culture","EXPERIMENTAL","Eligible GV oocytes are cultured for 24 hours in CSCMC medium with co-culture using iPSC-derived ovarian support cells prepared according to laboratory SOPs.",[19],"Other: Rescue in vitro maturation with iPSC-derived ovarian support cell co-culture",[21,26],{"type":6,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"Conventional rescue in vitro maturation","Standard rescue in vitro maturation of denuded germinal vesicle oocytes in CSCMC culture medium for 24 hours under routine IVF laboratory conditions.",[9],null,{"type":6,"name":27,"description":28,"armGroupLabels":29,"otherNames":25},"Rescue in vitro maturation with iPSC-derived ovarian support cell co-culture","Rescue in vitro maturation of denuded germinal vesicle oocytes in CSCMC culture medium for 24 hours with co-culture using iPSC-derived ovarian support cells supplied by Dioseve Inc. and prepared according to the laboratory SOP.",[15],[31],{"name":32,"affiliation":5,"role":33},"Tuyet Thi-Diem Hoang, MD","PRINCIPAL_INVESTIGATOR",[35],{"name":36,"role":37,"phone":38,"phoneExt":25,"email":39},"Huy Phuong Tran, PhD","CONTACT","+84 896 416 098","tranphuonghuy1994@gmail.com",[41],{"facility":42,"status":25,"city":43,"state":25,"zip":44,"country":45,"countryCode":46,"cosmosGeoPoint":47,"geoPoint":52,"contacts":53},"Infertility Department","Ho Chi Minh City","700000","Vietnam","VN",{"type":48,"coordinates":49},"Point",[50,51],106.62965,10.82302,{"lat":51,"lon":50},[54],{"name":36,"role":37,"phone":38,"phoneExt":25,"email":39},{"type":33,"investigatorFullName":56,"investigatorTitle":57,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"Thi Thanh Thuy Tran, MD","Principal Investigator",[59],{"name":60,"class":61},"Dioseve Inc.","UNKNOWN","100635951",false,"NCT07559357","OSC Co-culture for Rescue IVM of Human GV Oocytes","Effect of iPSC-Derived Ovarian Support Cell Co-culture on Rescue In Vitro Maturation of Human Germinal Vesicle Oocytes: A Randomized Sibling-Oocyte Controlled Trial","OSC-rIVM","Inclusion Criteria:\n\n* Women aged 18 to 45 years.\n* At least 2 GV oocytes retrieved in a single oocyte retrieval cycle.\n* Voluntary informed consent from the couple to participate in the study.\n* Agreement that all embryos generated from the study will be used for research purposes only and will not be transferred for clinical treatment.\n\nExclusion Criteria:\n\n* Sperm obtained through surgical retrieval procedures, including PESA, MESA, TESE, or micro-TESE.\n* Use of donor gametes, including donor oocytes or donor sperm.\n* Participants with GV oocytes showing obvious morphological abnormalities, such as degeneration, severe deformation, or marked cytoplasmic abnormalities.","FEMALE","18 Years","45 Years",{"count":73,"type":74},102,"ESTIMATED","INTERVENTIONAL",[77],"NA","This single-center randomized sibling-oocyte controlled trial evaluates whether co-culture with induced pluripotent stem cell (iPSC)-derived ovarian support cells (OSCs) improves rescue in vitro maturation (r-IVM) outcomes of surplus germinal vesicle (GV) oocytes collected during routine IVF treatment. Eligible GV oocytes from each enrolled participant are allocated within participant in a 1:1 ratio to either conventional r-IVM or r-IVM with OSC co-culture. The primary outcome is the metaphase II (MII) maturation rate after 24 hours of culture. Secondary outcomes include fertilization rate, day 3 embryo formation, good-quality day 3 embryo rate, blastocyst formation, and good-quality blastocyst rate. All embryos generated in the study are for research purposes only and will not be used for clinical embryo transfer.",[80,81],"Oocyte Maturation","Infertility",[83,84,85,86,87,88,89,90],"Rescue in vitro maturation","r-IVM","Germinal vesicle oocyte","iPSC-derived ovarian support cells","OSC co-culture","Embryo development","IVF","Sibling-oocyte trial","NOT_YET_RECRUITING","2026-04-23",{"date":94,"type":95},"2026-04-30","ACTUAL",{"date":97,"type":74},"2026-06",{"date":99,"type":74},"2027-05",{"name":5,"class":6},1]