[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100538815":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":20,"centralContacts":25,"locations":31,"responsibleParty":45,"collaborators":11,"id":47,"slug":11,"hasResults":48,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":11,"eligibilityCriteria":52,"healthyVolunteers":48,"sex":53,"minAge":54,"maxAge":11,"enrollmentInfo":55,"targetDuration":11,"studyType":58,"phases":59,"briefSummary":61,"conditions":62,"keywords":64,"overallStatus":33,"whyStopped":11,"lastUpdateSubmitDate":68,"lastUpdatePostDateStruct":69,"startDateStruct":72,"completionDateStruct":74,"leadSponsor":76,"locationsCount":77},{"fullName":5,"class":6},"University of Wisconsin, Madison","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"WBI with SIB","EXPERIMENTAL",null,[13],"Radiation: Radiation Therapy",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":11},"RADIATION","Radiation Therapy","WBI with SIB delivered over 5 fractions",[9],[21],{"name":22,"affiliation":23,"role":24},"Jessica Schuster, MD","UW Carbone Cancer Center","PRINCIPAL_INVESTIGATOR",[26],{"name":27,"role":28,"phone":29,"phoneExt":11,"email":30},"Cancer Connect","CONTACT","800-622-8922","clinicaltrials@cancer.wisc.edu",[32],{"facility":23,"status":33,"city":34,"state":35,"zip":36,"country":37,"countryCode":38,"cosmosGeoPoint":39,"geoPoint":44,"contacts":11},"RECRUITING","Madison","Wisconsin","53792","United States","US",{"type":40,"coordinates":41},"Point",[42,43],-89.40123,43.07305,{"lat":43,"lon":42},{"type":46,"investigatorFullName":11,"investigatorTitle":11,"investigatorAffiliation":11,"oldNameTitle":11,"oldOrganization":11},"SPONSOR","100538815",false,"NCT06295744","Outcomes and Cosmesis With Whole Breast Irradiation and Boost","Patient-Reported Outcomes and Cosmesis Following Five Fraction Whole Breast Irradiation With Simultaneous Integrated Boost","Inclusion Criteria:\n\n* Ability to understand and the willingness to sign a written informed consent document\n* Histologically confirmed early stage (stage T1-T2) invasive carcinoma of the breast or DCIS\n* Breast conserving surgery with negative margins and negative nodes (surgical axillary staging not mandatory), stage N0 or Nx\n* Treatment plan should include breast conserving surgery and adjuvant whole breast irradiation (WBI) therapy delivered with 3D-CRT or IMRT techniques\n* Treatment plan includes breast tumor bed boost\n* Willingness to comply with all study procedures and be available for the duration of the study\n\nExclusion Criteria:\n\n* Mastectomy of ipsilateral breast\n* Lack of histologic diagnosis\n* Histologic involvement of the axillary or regional nodes or metastatic disease\n* Accelerated partial breast irradiation treatment plan\n* Previous history of non-breast malignancy diagnosed in the past 5 years except for basal or squamous cell cancer of the skin\n* Previous history of chest radiation therapy\n* Previous history of ipsilateral breast cancer\n* Concurrent cytotoxic chemotherapy\n* Active connective tissue disease including scleroderma\n* Inability or unwillingness to return for required follow up visit","FEMALE","18 Years",{"count":56,"type":57},50,"ESTIMATED","INTERVENTIONAL",[60],"NA","This study is being done to evaluate cosmetic, patient-reported outcome measures (PROMs), and toxicities for women undergoing ultra-short whole breast irradiation (WBI) therapy with simultaneous integrated boost (SIB). 50 participants will be on study for up to 60 months.",[63],"Early-stage Breast Cancer",[65,66,67],"Cosmesis","Simultaneous Integrated Boost","Whole Breast Irradiation","2026-06-09",{"date":70,"type":71},"2026-06-10","ACTUAL",{"date":73,"type":71},"2024-04-17",{"date":75,"type":57},"2032-02",{"name":5,"class":6},1]