[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100614022":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":39,"centralContacts":43,"locations":52,"responsibleParty":76,"collaborators":79,"id":83,"slug":47,"hasResults":84,"nctId":85,"briefTitle":86,"officialTitle":87,"acronym":47,"eligibilityCriteria":88,"healthyVolunteers":84,"sex":89,"minAge":90,"maxAge":47,"enrollmentInfo":91,"targetDuration":47,"studyType":94,"phases":95,"briefSummary":97,"conditions":98,"keywords":100,"overallStatus":55,"whyStopped":47,"lastUpdateSubmitDate":106,"lastUpdatePostDateStruct":107,"startDateStruct":110,"completionDateStruct":112,"leadSponsor":114,"locationsCount":115},{"fullName":5,"class":6},"University of Plymouth","OTHER",[8,15],{"label":9,"type":10,"description":11,"interventionNames":12},"Sodium bicarbonate toothpaste (67%)","ACTIVE_COMPARATOR","Description: Intervention includes receiving Corsodyl Complete Protection Extra Fresh Toothpaste to use which contains sodium bicarbonate.",[13,14],"Procedure: no treatment received","Procedure: Periodontal treatment and OHI",{"label":16,"type":17,"description":18,"interventionNames":19},"Fluoride toothpaste (1450ppm)","SHAM_COMPARATOR","Control group to receive Aquafresh Fresh and Minty Toothpaste",[13,14],[21,28,34],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"PROCEDURE","no treatment received","Baseline; 0 months (no periodontal treatment)",[16,9],[27],"Gum treatment (baseline)",{"type":22,"name":29,"description":30,"armGroupLabels":31,"otherNames":32},"Periodontal treatment and OHI","3 months periodontal treatment \\& OHI",[16,9],[33],"Gum treatment (3 mons)",{"type":22,"name":29,"description":35,"armGroupLabels":36,"otherNames":37},"6 months periodontal treatment \\& OHI",[16,9],[38],"Gum treatment (6 mons)",[40],{"name":41,"affiliation":5,"role":42},"Zoe Brookes, BDS, MJDF, PCHE, SFHEA, PhD","PRINCIPAL_INVESTIGATOR",[44,49],{"name":41,"role":45,"phone":46,"phoneExt":47,"email":48},"CONTACT","01752 586828",null,"zoe.brookes@plymouth.ac.uk",{"name":50,"role":45,"phone":47,"phoneExt":47,"email":51},"Amazon Doble, BSc, PhD","amazon.doble@plymouth.ac.uk",[53],{"facility":54,"status":55,"city":56,"state":47,"zip":57,"country":58,"countryCode":59,"cosmosGeoPoint":60,"geoPoint":65,"contacts":66},"Derriford Dental Education Facility","RECRUITING","Plymouth","PL4 8AA","United Kingdom","UK",{"type":61,"coordinates":62},"Point",[63,64],-4.14305,50.37153,{"lat":64,"lon":63},[67,71,72,73],{"name":68,"role":45,"phone":69,"phoneExt":47,"email":70},"Robert Witton, BDS","+44 1752 583579","robert.witton@plymouth.ac.uk",{"name":41,"role":45,"phone":46,"phoneExt":47,"email":48},{"name":41,"role":42,"phone":47,"phoneExt":47,"email":47},{"name":74,"role":75,"phone":47,"phoneExt":47,"email":47},"amazon doble, BSc, PhD","SUB_INVESTIGATOR",{"type":42,"investigatorFullName":77,"investigatorTitle":78,"investigatorAffiliation":5,"oldNameTitle":47,"oldOrganization":47},"Zoe Brookes","Associate Head of School (Teaching & Learning)",[80],{"name":81,"class":82},"HALEON","INDUSTRY","100614022",false,"NCT07274189","Periodontal Health and Sodium Bicarbonate Toothpaste","Maintenance of Periodontal Health With Daily Use of Sodium Bicarbonate Toothpaste","Inclusion Criteria:\n\n* Adult participants \\>18 years, of any gender will be recruited.\n\nExclusion Criteria:\n\n* Full dentures\n* Diabetics\n* Cancer diagnosis\n* Pregnancy\n* Use of antibiotics (\\\u003C3 months prior to participation)\n* Use of antibacterial mouthwash\n* Inorganic nitrates taken less than 4 weeks before the study\n* Immunosuppressants taken less than 4 weeks before the study\n* BPE's score of less than 3, and or\u002F BPE score of more than two 4's.","ALL","18 Years",{"count":92,"type":93},100,"ESTIMATED","INTERVENTIONAL",[96],"NA","The goal of this clinical trial is to determine whether sodium bicarbonate fluoride toothpaste can help maintain periodontal health in adults who have undergone non-surgical periodontal treatment. The main question it aims to answer is:\n\nDoes daily use of toothpaste affect the following outcomes: clinical oral health (plaque scores, gingival bleeding scores and periodontal pocket depths), salivary biochemical markers and the oral microbiome.\n\nOutcomes measures will be recorded at 0,3, and 6 months, during which time participants will receive either the treatment or placebo toothpaste and undergo oral hygiene instruction and PMPR over 6 months.",[99],"Periodontal Diseases",[101,102,103,104,105],"periodontitis","periodontal disease","sodium bicarbonate","toothpaste","microbiome","2025-12-15",{"date":108,"type":109},"2025-12-22","ACTUAL",{"date":111,"type":109},"2024-12-04",{"date":113,"type":93},"2027-01-30",{"name":5,"class":6},1]