A Single-arm, Open-label Clinical Study to Evaluate the Efficacy and Safety of VRT106 in Combination With Chemotherapy for Resectable Pancreatic Cancer

Trial statusRecruiting
Trial phasePhase 1, Phase 2
Trial typeInterventional
Biological sexAll
Age18-75
SponsorGuangdong Provincial People's Hospital

About this trial

This is a single-center, single-arm, open investigator-initiated clinical study to evaluate the efficacy and safety of VRT106 in combination with chemotherapy in the treatment of resectable pancreatic cancer.

Eligibility criteria

Qualifiers

Subject voluntarily agrees to participate in this study and signs an Institutional Review Board -approved informed consent prior to performing any of the Screening Visit procedures.

Males and females at 18-75 years of age, inclusive, at the Screening Visit.

Have a clinical diagnosis of pancreatic cancer.

An Eastern Cooperative Oncology Group (ECOG) score of 0 or 1.

Disqualifiers

Prior treatment with other oncolytic virus or systemic therapy for pancreatic cancer.

Previous allogeneic hematopoietic stem cell transplantation or organ transplantation.

Immunocompromised patients.

Known alcohol or drug dependency.

Trial design

Treatments tested in this trial

  • Oncolytic virus VRT106
  • Chemotherapy

Treatment groups

18 Participants
are divided into 1 treatment group

Sponsors and collaborators

Guangdong Provincial People's Hospital

Lead sponsor

Guangzhou Virotech Pharmaceutical Co., Ltd.

Collaborator