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Participants with active hepatitis B infection or active hepatitis C\n7. Participants with active HIV infection. Patients living with HIV may be eligible if they have adequate CD4+ T-cell count and no history of AIDS-defining opportunistic infections in the past 12 months\n8. Receipt of any strong inhibitor or inducer of CYP3A4\n9. Impaired hepatic or renal function, inadequate bone marrow reserve or organ function\n10. Any clinically important abnormalities in rhythm, conduction, or morphology on resting ECG or any factor that increases the risk of QTc prolongation or of arrhythmic events , or congestive heart failure Grade III-IV according to the New York Heart Association, myocardial infarction, or unstable angina within the previous 6 months\n11. Uncontrolled hypertension\n12. 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