[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100321141":3},{"organization":4,"armGroups":7,"interventions":52,"overallOfficials":73,"centralContacts":77,"locations":83,"responsibleParty":761,"collaborators":81,"id":763,"slug":81,"hasResults":764,"nctId":765,"briefTitle":766,"officialTitle":767,"acronym":81,"eligibilityCriteria":768,"healthyVolunteers":764,"sex":769,"minAge":770,"maxAge":81,"enrollmentInfo":771,"targetDuration":81,"studyType":774,"phases":775,"briefSummary":777,"conditions":778,"keywords":782,"overallStatus":258,"whyStopped":81,"lastUpdateSubmitDate":801,"lastUpdatePostDateStruct":802,"startDateStruct":805,"completionDateStruct":807,"leadSponsor":809,"locationsCount":810},{"fullName":5,"class":6},"Pfizer","INDUSTRY",[8,14,18,22,27,31,35,39,43,47],{"label":9,"type":10,"description":11,"interventionNames":12},"Dose Escalation (Part 1A)","EXPERIMENTAL","Participants with SCLC, CRPC and FL will receive mevrometostat at escalating dose levels",[13],"Drug: Mervometostat (PF-06821497)",{"label":15,"type":10,"description":16,"interventionNames":17},"Dose Escalation (Part 1B)","Participants with FL will receive mevrometostat at escalating dose levels",[13],{"label":19,"type":10,"description":20,"interventionNames":21},"Dose Escalation (Part 1C)","Participants with mCRPC will receive mevrometostat at escalating dose levels.",[13],{"label":23,"type":10,"description":24,"interventionNames":25},"Dose Escalation (Part 2A)","Participants with mCRPC and SCLC will receive mevrometostat at escalating dose levels in combination with SOC.",[13,26],"Drug: Enzalutamide",{"label":28,"type":10,"description":29,"interventionNames":30},"Dose Expansion (Part 2B)","Participants with CRPC will receive mevrometostat in combination with SOC or SOC alone.",[13,26],{"label":32,"type":10,"description":33,"interventionNames":34},"Japan Cohort","Participants with CRPC will receive mevrometostat at one or two doses",[13],{"label":36,"type":10,"description":37,"interventionNames":38},"China cohort","Participants will receive mevrometostat at one or two doses",[13],{"label":40,"type":10,"description":41,"interventionNames":42},"Dose Expansion (Part 2C)","Participants with mCRPC will receive mevrometostat at a different dose\u002Fdosing regimen than that of Part 2B in combination with SOC",[13,26],{"label":44,"type":10,"description":45,"interventionNames":46},"BE Substudy","In the assessment phase, each enrolled participant will receive single doses of the 2 different mevrometostat formulations in 3 periods with alternating dosing and washout between each dose. In the maintenance phase, each participant will receive mevrometostat 2 times a day and enzalutamide 1 time a day.",[13,26],{"label":48,"type":10,"description":49,"interventionNames":50},"DDI Substudy","The DDI substudy assessment phase will consist of 2 Cohorts, Cohort 1 (monotherapy cohort) and Cohort 2 (combination cohort). In the Cohort 1 assessment phase, each enrolled participant will receive a combination of mevrometostat and itraconazole based on preset schedule. In the Cohort 2 assessment phase, each enrolled participant will receive a combination of mevrometostat, enzalutamide, and itraconazole based on preset schedule. In the maintenance phase, each participant will receive mevrometostat 2 times a day and enzalutamide 1 time a day.",[13,26,51],"Drug: Itraconazole",[53,60,65],{"type":54,"name":55,"description":56,"armGroupLabels":57,"otherNames":58},"DRUG","Mervometostat (PF-06821497)","Oral continuous",[44,36,48,9,15,19,23,28,40,32],[59],"EZH2i",{"type":54,"name":61,"description":56,"armGroupLabels":62,"otherNames":63},"Enzalutamide",[44,48,23,28,40],[64],"Xtandi",{"type":54,"name":66,"description":67,"armGroupLabels":68,"otherNames":69},"Itraconazole","Oral solution",[48],[70,71,72],"Sporanox","Tolsura","Onmel",[74],{"name":75,"affiliation":5,"role":76},"Pfizer CT.gov Call Center","STUDY_DIRECTOR",[78],{"name":75,"role":79,"phone":80,"phoneExt":81,"email":82},"CONTACT","1-800-718-1021",null,"ClinicalTrials.gov_Inquiries@pfizer.com",[84,98,103,109,116,126,135,140,150,160,165,174,179,188,196,206,211,216,221,231,241,247,256,267,277,282,292,297,307,312,322,327,337,346,351,356,361,371,377,382,391,396,406,416,425,434,440,451,463,473,483,489,499,509,521,532,541,550,562,571,577,583,592,601,607,613,622,633,643,649,655,665,677,686,696,705,711,717,725,731,737,743,752],{"facility":85,"status":86,"city":87,"state":88,"zip":89,"country":90,"countryCode":91,"cosmosGeoPoint":92,"geoPoint":97,"contacts":81},"Banner-University Medical Center Tucson","ACTIVE_NOT_RECRUITING","Tucson","Arizona","85719","United States","US",{"type":93,"coordinates":94},"Point",[95,96],-110.92648,32.22174,{"lat":96,"lon":95},{"facility":99,"status":86,"city":87,"state":88,"zip":89,"country":90,"countryCode":91,"cosmosGeoPoint":100,"geoPoint":102,"contacts":81},"The University of Arizona Cancer Center-North Campus",{"type":93,"coordinates":101},[95,96],{"lat":96,"lon":95},{"facility":104,"status":86,"city":87,"state":88,"zip":105,"country":90,"countryCode":91,"cosmosGeoPoint":106,"geoPoint":108,"contacts":81},"The University of Arizona Cancer Center","85724",{"type":93,"coordinates":107},[95,96],{"lat":96,"lon":95},{"facility":110,"status":111,"city":87,"state":88,"zip":112,"country":90,"countryCode":91,"cosmosGeoPoint":113,"geoPoint":115,"contacts":81},"Arizona Urology Specialists, PLLC","TERMINATED","85741",{"type":93,"coordinates":114},[95,96],{"lat":96,"lon":95},{"facility":117,"status":86,"city":118,"state":119,"zip":120,"country":90,"countryCode":91,"cosmosGeoPoint":121,"geoPoint":125,"contacts":81},"Pacific Cancer Medical Center INC","Anaheim","California","92801",{"type":93,"coordinates":122},[123,124],-117.9145,33.83529,{"lat":124,"lon":123},{"facility":127,"status":86,"city":128,"state":119,"zip":129,"country":90,"countryCode":91,"cosmosGeoPoint":130,"geoPoint":134,"contacts":81},"City of Hope (City of Hope National Medical Center, City of Hope Medical Center)","Duarte","91010",{"type":93,"coordinates":131},[132,133],-117.97729,34.13945,{"lat":133,"lon":132},{"facility":136,"status":86,"city":128,"state":119,"zip":129,"country":90,"countryCode":91,"cosmosGeoPoint":137,"geoPoint":139,"contacts":81},"City of Hope Investigational Drug Services (IDS)",{"type":93,"coordinates":138},[132,133],{"lat":133,"lon":132},{"facility":141,"status":86,"city":142,"state":143,"zip":144,"country":90,"countryCode":91,"cosmosGeoPoint":145,"geoPoint":149,"contacts":81},"Norwalk Hospital","Norwalk","Connecticut","06856",{"type":93,"coordinates":146},[147,148],-73.4079,41.1176,{"lat":148,"lon":147},{"facility":151,"status":86,"city":152,"state":153,"zip":154,"country":90,"countryCode":91,"cosmosGeoPoint":155,"geoPoint":159,"contacts":81},"The University of Kansas Cancer Center, Investigational Drug Services","Fairway","Kansas","66205",{"type":93,"coordinates":156},[157,158],-94.6319,39.02223,{"lat":158,"lon":157},{"facility":161,"status":86,"city":152,"state":153,"zip":154,"country":90,"countryCode":91,"cosmosGeoPoint":162,"geoPoint":164,"contacts":81},"The University of Kansas Clinical Research Center",{"type":93,"coordinates":163},[157,158],{"lat":158,"lon":157},{"facility":166,"status":86,"city":167,"state":153,"zip":168,"country":90,"countryCode":91,"cosmosGeoPoint":169,"geoPoint":173,"contacts":81},"The University of Kansas Hospital","Kansas City","66160",{"type":93,"coordinates":170},[171,172],-94.62746,39.11417,{"lat":172,"lon":171},{"facility":175,"status":86,"city":167,"state":153,"zip":168,"country":90,"countryCode":91,"cosmosGeoPoint":176,"geoPoint":178,"contacts":81},"The University of Kansas Medical Center Medical Office Building",{"type":93,"coordinates":177},[171,172],{"lat":172,"lon":171},{"facility":180,"status":86,"city":181,"state":153,"zip":182,"country":90,"countryCode":91,"cosmosGeoPoint":183,"geoPoint":187,"contacts":81},"The University of Kansas Cancer Center - Indian Creek Campus","Overland Park","66211",{"type":93,"coordinates":184},[185,186],-94.67079,38.98223,{"lat":186,"lon":185},{"facility":189,"status":86,"city":190,"state":153,"zip":154,"country":90,"countryCode":91,"cosmosGeoPoint":191,"geoPoint":195,"contacts":81},"The University of Kansas Cancer Center","Westwood",{"type":93,"coordinates":192},[193,194],-94.6169,39.04056,{"lat":194,"lon":193},{"facility":197,"status":86,"city":198,"state":199,"zip":200,"country":90,"countryCode":91,"cosmosGeoPoint":201,"geoPoint":205,"contacts":81},"Norton Cancer Institute Pharmacy, Downtown Pharmacy","Louisville","Kentucky","40202",{"type":93,"coordinates":202},[203,204],-85.75941,38.25424,{"lat":204,"lon":203},{"facility":207,"status":86,"city":198,"state":199,"zip":200,"country":90,"countryCode":91,"cosmosGeoPoint":208,"geoPoint":210,"contacts":81},"Norton Cancer Institute Pharmacy",{"type":93,"coordinates":209},[203,204],{"lat":204,"lon":203},{"facility":212,"status":86,"city":198,"state":199,"zip":200,"country":90,"countryCode":91,"cosmosGeoPoint":213,"geoPoint":215,"contacts":81},"Norton Cancer Institute, Norton Healthcare Pavilion",{"type":93,"coordinates":214},[203,204],{"lat":204,"lon":203},{"facility":217,"status":86,"city":198,"state":199,"zip":200,"country":90,"countryCode":91,"cosmosGeoPoint":218,"geoPoint":220,"contacts":81},"Norton Hospital",{"type":93,"coordinates":219},[203,204],{"lat":204,"lon":203},{"facility":222,"status":111,"city":223,"state":224,"zip":225,"country":90,"countryCode":91,"cosmosGeoPoint":226,"geoPoint":230,"contacts":81},"Maryland Oncology Hematology, P.A.","Rockville","Maryland","20850",{"type":93,"coordinates":227},[228,229],-77.15276,39.084,{"lat":229,"lon":228},{"facility":232,"status":86,"city":233,"state":234,"zip":235,"country":90,"countryCode":91,"cosmosGeoPoint":236,"geoPoint":240,"contacts":81},"Brigham and Women's Hospital","Boston","Massachusetts","02115",{"type":93,"coordinates":237},[238,239],-71.05977,42.35843,{"lat":239,"lon":238},{"facility":242,"status":86,"city":233,"state":234,"zip":243,"country":90,"countryCode":91,"cosmosGeoPoint":244,"geoPoint":246,"contacts":81},"Dana Farber Cancer Institute","02215",{"type":93,"coordinates":245},[238,239],{"lat":239,"lon":238},{"facility":248,"status":86,"city":249,"state":234,"zip":250,"country":90,"countryCode":91,"cosmosGeoPoint":251,"geoPoint":255,"contacts":81},"Dana Farber Cancer Institute- Chestnut Hill","Newton","02459",{"type":93,"coordinates":252},[253,254],-71.20922,42.33704,{"lat":254,"lon":253},{"facility":257,"status":258,"city":259,"state":260,"zip":261,"country":90,"countryCode":91,"cosmosGeoPoint":262,"geoPoint":266,"contacts":81},"Oncology Hematology West, PC dba Nebraska Cancer Specialists","RECRUITING","Omaha","Nebraska","68130",{"type":93,"coordinates":263},[264,265],-95.94043,41.25626,{"lat":265,"lon":264},{"facility":268,"status":86,"city":269,"state":270,"zip":271,"country":90,"countryCode":91,"cosmosGeoPoint":272,"geoPoint":276,"contacts":81},"Hackensack University Medical Center","Hackensack","New Jersey","07601",{"type":93,"coordinates":273},[274,275],-74.04347,40.88593,{"lat":275,"lon":274},{"facility":278,"status":86,"city":269,"state":270,"zip":271,"country":90,"countryCode":91,"cosmosGeoPoint":279,"geoPoint":281,"contacts":81},"John Theurer Cancer Center at Hackensack University Medical Center",{"type":93,"coordinates":280},[274,275],{"lat":275,"lon":274},{"facility":283,"status":258,"city":284,"state":285,"zip":286,"country":90,"countryCode":91,"cosmosGeoPoint":287,"geoPoint":291,"contacts":81},"OU Health University of Oklahoma Medical Center","Oklahoma City","Oklahoma","73104",{"type":93,"coordinates":288},[289,290],-97.51643,35.46756,{"lat":290,"lon":289},{"facility":293,"status":258,"city":284,"state":285,"zip":286,"country":90,"countryCode":91,"cosmosGeoPoint":294,"geoPoint":296,"contacts":81},"Stephenson Cancer Center (chemo location)",{"type":93,"coordinates":295},[289,290],{"lat":290,"lon":289},{"facility":298,"status":258,"city":299,"state":300,"zip":301,"country":90,"countryCode":91,"cosmosGeoPoint":302,"geoPoint":306,"contacts":81},"Carolina Urologic Research Center","Myrtle Beach","South Carolina","29572",{"type":93,"coordinates":303},[304,305],-78.88669,33.68906,{"lat":305,"lon":304},{"facility":308,"status":258,"city":299,"state":300,"zip":301,"country":90,"countryCode":91,"cosmosGeoPoint":309,"geoPoint":311,"contacts":81},"Parkway Surgery Center",{"type":93,"coordinates":310},[304,305],{"lat":305,"lon":304},{"facility":313,"status":258,"city":314,"state":315,"zip":316,"country":90,"countryCode":91,"cosmosGeoPoint":317,"geoPoint":321,"contacts":81},"Sarah Cannon Research Institute - Pharmacy","Nashville","Tennessee","37203",{"type":93,"coordinates":318},[319,320],-86.78444,36.16589,{"lat":320,"lon":319},{"facility":323,"status":258,"city":314,"state":315,"zip":316,"country":90,"countryCode":91,"cosmosGeoPoint":324,"geoPoint":326,"contacts":81},"SCRI Oncology Partners",{"type":93,"coordinates":325},[319,320],{"lat":320,"lon":319},{"facility":328,"status":111,"city":329,"state":330,"zip":331,"country":90,"countryCode":91,"cosmosGeoPoint":332,"geoPoint":336,"contacts":81},"Texas Oncology - Austin Midtown","Austin","Texas","78705",{"type":93,"coordinates":333},[334,335],-97.74306,30.26715,{"lat":335,"lon":334},{"facility":338,"status":86,"city":339,"state":330,"zip":340,"country":90,"countryCode":91,"cosmosGeoPoint":341,"geoPoint":345,"contacts":81},"University of Texas Southwestern Medical Center - Simmons Cancer Center","Dallas","75390",{"type":93,"coordinates":342},[343,344],-96.80667,32.78306,{"lat":344,"lon":343},{"facility":347,"status":86,"city":339,"state":330,"zip":340,"country":90,"countryCode":91,"cosmosGeoPoint":348,"geoPoint":350,"contacts":81},"UT Southwestern Medical Center",{"type":93,"coordinates":349},[343,344],{"lat":344,"lon":343},{"facility":352,"status":86,"city":339,"state":330,"zip":340,"country":90,"countryCode":91,"cosmosGeoPoint":353,"geoPoint":355,"contacts":81},"UT Southwestern University Hospital - William P. Clements, Jr",{"type":93,"coordinates":354},[343,344],{"lat":344,"lon":343},{"facility":357,"status":86,"city":339,"state":330,"zip":340,"country":90,"countryCode":91,"cosmosGeoPoint":358,"geoPoint":360,"contacts":81},"UT Southwestern University Hospital - Zale Lipshy",{"type":93,"coordinates":359},[343,344],{"lat":344,"lon":343},{"facility":362,"status":363,"city":364,"state":330,"zip":365,"country":90,"countryCode":91,"cosmosGeoPoint":366,"geoPoint":370,"contacts":81},"NEXT Dallas","NOT_YET_RECRUITING","Irving","75039",{"type":93,"coordinates":367},[368,369],-96.94889,32.81402,{"lat":369,"lon":368},{"facility":372,"status":111,"city":364,"state":330,"zip":373,"country":90,"countryCode":91,"cosmosGeoPoint":374,"geoPoint":376,"contacts":81},"US Oncology Investigational Product Center (IPC)","75063",{"type":93,"coordinates":375},[368,369],{"lat":369,"lon":368},{"facility":378,"status":111,"city":364,"state":330,"zip":373,"country":90,"countryCode":91,"cosmosGeoPoint":379,"geoPoint":381,"contacts":81},"US Oncology Investigational Products Center",{"type":93,"coordinates":380},[368,369],{"lat":369,"lon":368},{"facility":383,"status":363,"city":384,"state":330,"zip":385,"country":90,"countryCode":91,"cosmosGeoPoint":386,"geoPoint":390,"contacts":81},"NEXT Oncology","San Antonio","78229",{"type":93,"coordinates":387},[388,389],-98.49363,29.42412,{"lat":389,"lon":388},{"facility":383,"status":86,"city":384,"state":330,"zip":392,"country":90,"countryCode":91,"cosmosGeoPoint":393,"geoPoint":395,"contacts":81},"78240",{"type":93,"coordinates":394},[388,389],{"lat":389,"lon":388},{"facility":397,"status":86,"city":398,"state":399,"zip":400,"country":90,"countryCode":91,"cosmosGeoPoint":401,"geoPoint":405,"contacts":81},"Virginia Cancer Specialists, PC","Fairfax","Virginia","22031",{"type":93,"coordinates":402},[403,404],-77.30637,38.84622,{"lat":404,"lon":403},{"facility":407,"status":86,"city":408,"state":409,"zip":410,"country":90,"countryCode":91,"cosmosGeoPoint":411,"geoPoint":415,"contacts":81},"Olympic Medical Center","Port Angeles","Washington","98362",{"type":93,"coordinates":412},[413,414],-123.43074,48.11815,{"lat":414,"lon":413},{"facility":417,"status":86,"city":418,"state":409,"zip":419,"country":90,"countryCode":91,"cosmosGeoPoint":420,"geoPoint":424,"contacts":81},"Fred Hutchinson Cancer Center Alliance Peninsula","Poulsbo","98370",{"type":93,"coordinates":421},[422,423],-122.64654,47.73593,{"lat":423,"lon":422},{"facility":426,"status":86,"city":427,"state":409,"zip":428,"country":90,"countryCode":91,"cosmosGeoPoint":429,"geoPoint":433,"contacts":81},"Fred Hutchinson Cancer Center","Seattle","98109",{"type":93,"coordinates":430},[431,432],-122.33207,47.60621,{"lat":432,"lon":431},{"facility":435,"status":86,"city":427,"state":409,"zip":436,"country":90,"countryCode":91,"cosmosGeoPoint":437,"geoPoint":439,"contacts":81},"University of Washington Medical Center","98195",{"type":93,"coordinates":438},[431,432],{"lat":432,"lon":431},{"facility":441,"status":111,"city":442,"state":81,"zip":443,"country":444,"countryCode":445,"cosmosGeoPoint":446,"geoPoint":450,"contacts":81},"Specialized Hospital for Active Treatment of Oncology - Haskovo","Haskovo","6300","Bulgaria","BG",{"type":93,"coordinates":447},[448,449],25.55557,41.93415,{"lat":449,"lon":448},{"facility":452,"status":86,"city":453,"state":454,"zip":455,"country":456,"countryCode":457,"cosmosGeoPoint":458,"geoPoint":462,"contacts":81},"The First Affiliated Hospital of Guangzhou Medical University","Guangzhou","Guangdong","510120","China","CN",{"type":93,"coordinates":459},[460,461],113.25,23.11667,{"lat":461,"lon":460},{"facility":464,"status":258,"city":465,"state":466,"zip":467,"country":456,"countryCode":457,"cosmosGeoPoint":468,"geoPoint":472,"contacts":81},"Hunan Cancer Hospital","Changsha","Hunan","410013",{"type":93,"coordinates":469},[470,471],112.97087,28.19874,{"lat":471,"lon":470},{"facility":474,"status":258,"city":475,"state":476,"zip":477,"country":456,"countryCode":457,"cosmosGeoPoint":478,"geoPoint":482,"contacts":81},"Nanjing Drum Tower Hospital The Affiliated Hospital of Nanjing University Medical School","Nanjing","Jiangsu","210008",{"type":93,"coordinates":479},[480,481],118.77778,32.06167,{"lat":481,"lon":480},{"facility":484,"status":258,"city":475,"state":476,"zip":485,"country":456,"countryCode":457,"cosmosGeoPoint":486,"geoPoint":488,"contacts":81},"Zhongda Hospital Southeast University","210009",{"type":93,"coordinates":487},[480,481],{"lat":481,"lon":480},{"facility":490,"status":258,"city":491,"state":492,"zip":493,"country":456,"countryCode":457,"cosmosGeoPoint":494,"geoPoint":498,"contacts":81},"West China Hospital, Sichuan University","Chengdu","Sichuan","610041",{"type":93,"coordinates":495},[496,497],104.06667,30.66667,{"lat":497,"lon":496},{"facility":500,"status":86,"city":501,"state":502,"zip":503,"country":456,"countryCode":457,"cosmosGeoPoint":504,"geoPoint":508,"contacts":81},"The First Affiliated Hospital of Wenzhou Medical University","Wenzhou","Zhejiang","325000",{"type":93,"coordinates":505},[506,507],120.66682,27.99942,{"lat":507,"lon":506},{"facility":510,"status":86,"city":511,"state":512,"zip":513,"country":514,"countryCode":515,"cosmosGeoPoint":516,"geoPoint":520,"contacts":81},"National Cancer Center Hospital East","Kashiwa","Chiba","277-8577","Japan","JP",{"type":93,"coordinates":517},[518,519],139.97732,35.86224,{"lat":519,"lon":518},{"facility":522,"status":86,"city":523,"state":81,"zip":524,"country":525,"countryCode":526,"cosmosGeoPoint":527,"geoPoint":531,"contacts":81},"Szpital Wojewódzki im. Mikołaja Kopernika w Koszalinie","Koszalin","75-581","Poland","PL",{"type":93,"coordinates":528},[529,530],16.17222,54.19438,{"lat":530,"lon":529},{"facility":533,"status":86,"city":534,"state":81,"zip":535,"country":525,"countryCode":526,"cosmosGeoPoint":536,"geoPoint":540,"contacts":81},"Centrum Medyczne MEDYK","Rzeszów","35-326",{"type":93,"coordinates":537},[538,539],21.99901,50.04132,{"lat":539,"lon":538},{"facility":542,"status":86,"city":543,"state":81,"zip":544,"country":525,"countryCode":526,"cosmosGeoPoint":545,"geoPoint":549,"contacts":81},"Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - Panstwowy Instytut Badawczy w Warszawie","Warsaw","02-781",{"type":93,"coordinates":546},[547,548],21.01178,52.22977,{"lat":548,"lon":547},{"facility":551,"status":86,"city":552,"state":553,"zip":554,"country":555,"countryCode":556,"cosmosGeoPoint":557,"geoPoint":561,"contacts":81},"Private Medical Institution \"Euromedservice\"","Pushkin","Sankt-Peterburg","196603","Russia","RU",{"type":93,"coordinates":558},[559,560],30.39642,59.71417,{"lat":560,"lon":559},{"facility":563,"status":86,"city":564,"state":81,"zip":565,"country":555,"countryCode":556,"cosmosGeoPoint":566,"geoPoint":570,"contacts":81},"LLC \"Neyro-klinika\"","Moscow","117186",{"type":93,"coordinates":567},[568,569],37.61781,55.75204,{"lat":569,"lon":568},{"facility":572,"status":111,"city":564,"state":81,"zip":573,"country":555,"countryCode":556,"cosmosGeoPoint":574,"geoPoint":576,"contacts":81},"Moscow GBUZ \"City clinical hospital n. a. S.P. Botkina\" of Moscow health department","125284",{"type":93,"coordinates":575},[568,569],{"lat":569,"lon":568},{"facility":578,"status":111,"city":564,"state":81,"zip":579,"country":555,"countryCode":556,"cosmosGeoPoint":580,"geoPoint":582,"contacts":81},"SBHI of Moscow City Clinical Hospital","129301",{"type":93,"coordinates":581},[568,569],{"lat":569,"lon":568},{"facility":584,"status":111,"city":585,"state":81,"zip":586,"country":555,"countryCode":556,"cosmosGeoPoint":587,"geoPoint":591,"contacts":81},"Budgetary Healthcare Institution of Omsk region \"Clinical Oncological Dispensary\"","Omsk","644013",{"type":93,"coordinates":588},[589,590],73.36859,54.99244,{"lat":590,"lon":589},{"facility":593,"status":111,"city":594,"state":81,"zip":595,"country":555,"countryCode":556,"cosmosGeoPoint":596,"geoPoint":600,"contacts":81},"Federal State Budgetary Institution National Medical Research Center n.a. V.A. Almazov","Saint Petersburg","197341",{"type":93,"coordinates":597},[598,599],30.31413,59.93863,{"lat":599,"lon":598},{"facility":602,"status":111,"city":594,"state":81,"zip":603,"country":555,"countryCode":556,"cosmosGeoPoint":604,"geoPoint":606,"contacts":81},"Federal State Budgetary Institution National Medical Research Center for Oncology n.a. N.N.","197758",{"type":93,"coordinates":605},[598,599],{"lat":599,"lon":598},{"facility":608,"status":111,"city":594,"state":81,"zip":609,"country":555,"countryCode":556,"cosmosGeoPoint":610,"geoPoint":612,"contacts":81},"Saint Petersburg State Budgetary Healthcare Institution \"City Clinical Oncological Dispensary\"","198255",{"type":93,"coordinates":611},[598,599],{"lat":599,"lon":598},{"facility":614,"status":111,"city":615,"state":81,"zip":616,"country":555,"countryCode":556,"cosmosGeoPoint":617,"geoPoint":621,"contacts":81},"State Budgetary Healthcare Institution of the Yaroslavl Region","Yaroslavl","150054",{"type":93,"coordinates":618},[619,620],39.87368,57.62987,{"lat":620,"lon":619},{"facility":623,"status":258,"city":624,"state":625,"zip":626,"country":627,"countryCode":81,"cosmosGeoPoint":628,"geoPoint":632,"contacts":81},"Seoul National University Bundang Hospital","Seongnam","Kyǒnggi-do","13620","South Korea",{"type":93,"coordinates":629},[630,631],127.7548,36.4052,{"lat":631,"lon":630},{"facility":634,"status":86,"city":635,"state":636,"zip":637,"country":627,"countryCode":81,"cosmosGeoPoint":638,"geoPoint":642,"contacts":81},"Seoul National University Hospital","Seoul","Seoul-teukbyeolsi [seoul]","03080",{"type":93,"coordinates":639},[640,641],126.9784,37.566,{"lat":641,"lon":640},{"facility":644,"status":86,"city":635,"state":636,"zip":645,"country":627,"countryCode":81,"cosmosGeoPoint":646,"geoPoint":648,"contacts":81},"Severance Hospital, Yonsei University Health System","03722",{"type":93,"coordinates":647},[640,641],{"lat":641,"lon":640},{"facility":650,"status":86,"city":635,"state":636,"zip":651,"country":627,"countryCode":81,"cosmosGeoPoint":652,"geoPoint":654,"contacts":81},"Ewha Womans University Mokdong Hospital","07985",{"type":93,"coordinates":653},[640,641],{"lat":641,"lon":640},{"facility":656,"status":86,"city":657,"state":658,"zip":659,"country":627,"countryCode":81,"cosmosGeoPoint":660,"geoPoint":664,"contacts":81},"Chungnam national university hospital","Daejeon","Taejǒn-kwangyǒkshi","35015",{"type":93,"coordinates":661},[662,663],127.38493,36.34913,{"lat":663,"lon":662},{"facility":666,"status":258,"city":667,"state":668,"zip":669,"country":670,"countryCode":671,"cosmosGeoPoint":672,"geoPoint":676,"contacts":81},"Institut Català d´Oncología (ICO)-H. Durán i Reynals","L'Hospitalet de Llobregat","Barecelona","08908","Spain","ES",{"type":93,"coordinates":673},[674,675],2.10028,41.35967,{"lat":675,"lon":674},{"facility":678,"status":86,"city":679,"state":679,"zip":680,"country":670,"countryCode":671,"cosmosGeoPoint":681,"geoPoint":685,"contacts":81},"Consorcio Hospitalario Provincial de Castellon","Castellon","12002",{"type":93,"coordinates":682},[683,684],-0.04935,39.98567,{"lat":684,"lon":683},{"facility":687,"status":258,"city":688,"state":689,"zip":690,"country":670,"countryCode":671,"cosmosGeoPoint":691,"geoPoint":695,"contacts":81},"Hospital Quironsalud Madrid","Pozuelo de Alarcón","Madrid","28223",{"type":93,"coordinates":692},[693,694],-3.81338,40.43293,{"lat":694,"lon":693},{"facility":697,"status":258,"city":698,"state":81,"zip":699,"country":670,"countryCode":671,"cosmosGeoPoint":700,"geoPoint":704,"contacts":81},"Hospital Quironsalud Barcelona","Barcelona","08023",{"type":93,"coordinates":701},[702,703],2.15899,41.38879,{"lat":703,"lon":702},{"facility":706,"status":258,"city":698,"state":81,"zip":707,"country":670,"countryCode":671,"cosmosGeoPoint":708,"geoPoint":710,"contacts":81},"Hospital Universitari Vall d'Hebron","08035",{"type":93,"coordinates":709},[702,703],{"lat":703,"lon":702},{"facility":712,"status":258,"city":698,"state":81,"zip":713,"country":670,"countryCode":671,"cosmosGeoPoint":714,"geoPoint":716,"contacts":81},"Hospital Clinic de Barcelona","08036",{"type":93,"coordinates":715},[702,703],{"lat":703,"lon":702},{"facility":718,"status":258,"city":689,"state":81,"zip":719,"country":670,"countryCode":671,"cosmosGeoPoint":720,"geoPoint":724,"contacts":81},"Hospital Universitario Ramon y Cajal","28034",{"type":93,"coordinates":721},[722,723],-3.70256,40.4165,{"lat":723,"lon":722},{"facility":726,"status":258,"city":689,"state":81,"zip":727,"country":670,"countryCode":671,"cosmosGeoPoint":728,"geoPoint":730,"contacts":81},"H.U. Fundación Jiménez Díaz","28040",{"type":93,"coordinates":729},[722,723],{"lat":723,"lon":722},{"facility":732,"status":258,"city":689,"state":81,"zip":733,"country":670,"countryCode":671,"cosmosGeoPoint":734,"geoPoint":736,"contacts":81},"Hospital Universitario 12 De Octubre","28041",{"type":93,"coordinates":735},[722,723],{"lat":723,"lon":722},{"facility":738,"status":258,"city":689,"state":81,"zip":739,"country":670,"countryCode":671,"cosmosGeoPoint":740,"geoPoint":742,"contacts":81},"Hospital Universitario HM Sanchinarro","28050",{"type":93,"coordinates":741},[722,723],{"lat":723,"lon":722},{"facility":744,"status":258,"city":745,"state":81,"zip":746,"country":670,"countryCode":671,"cosmosGeoPoint":747,"geoPoint":751,"contacts":81},"Hospital Universitario Virgen de la Victoria","Málaga","29010",{"type":93,"coordinates":748},[749,750],-4.42034,36.72016,{"lat":750,"lon":749},{"facility":753,"status":86,"city":754,"state":81,"zip":755,"country":670,"countryCode":671,"cosmosGeoPoint":756,"geoPoint":760,"contacts":81},"Hospital Universitari i Politecnic La Fe","Valencia","46026",{"type":93,"coordinates":757},[758,759],-0.37966,39.47391,{"lat":759,"lon":758},{"type":762,"investigatorFullName":81,"investigatorTitle":81,"investigatorAffiliation":81,"oldNameTitle":81,"oldOrganization":81},"SPONSOR","100321141",false,"NCT03460977","A Study of Mevrometostat for Treatment of Relapsed\u002FRefractory SCLC, Castration Resistant Prostate Cancer, and Follicular Lymphoma","A PHASE I DOSE ESCALATION AND EXPANDED COHORT STUDY OF PF 06821497 (MEVROMETOSTAT) IN THE TREATMENT OF ADULT PATIENTS WITH RELAPSED\u002FREFRACTORY SMALL CELL LUNG CANCER (SCLC), CASTRATION RESISTANT PROSTATE CANCER (CRPC) AND FOLLICULAR LYMPHOMA (FL)","Part 1 and Part 2 (Closed for enrollment).\n\nPart 3 Key Inclusion Criteria:\n\n* Histological or cytological diagnosis of castration resistant prostate cancer.\n* Eastern Cooperative Oncology Group (ECOG) Performance Status (PS) of 0-2 with expected life expectancy of at least 6 months.\n* Adequate bone marrow, renal, and liver function\n\nPart 3 Key Exclusion Criteria:\n\n* Prior irradiation to \\>25% of the bone marrow.\n* QTcF interval \\>480 msec at screening.\n* Hypertension that cannot be controlled by medications (\\>150\u002F90 mmHg despite optimal medical therapy).\n* Known or suspected hypersensitivity to PF 06821497 or any components or enzalutamide (CRPC)\n* Active inflammatory gastrointestinal disease, chronic diarrhea, known diverticular disease or previous gastric resection or lap band surgery.\n* Current use or anticipated need for food or drugs that are known strong and moderate CYP3A4\u002F5 inducers or inhibitors\n* Prior enzalutamide within the last 4 weeks\n* DDI SUBSTUDY:\n* history of CHF or evidence of ventricular dysfunction\n* fructose intolerance\n* coadministration of CYP3A4 substrates","ALL","18 Years",{"count":772,"type":773},453,"ESTIMATED","INTERVENTIONAL",[776],"PHASE1","The purpose of this study is to learn about the safety and effects of the study medicine (called Mevrometostat) for the possible treatment of Relapsed\u002F Refractory Small Cell Lung Cancer (SCLC), Castration Resistant Prostate Cancer (CRPC) and Follicular Lymphoma (FL). The study consists of 3 parts; Part 1 and 2 enrolled participants with SCLC, metastatic CRPC, and FL are closed for enrollment.\n\nPart 3, which is open for enrollment is seeking men who:\n\n* have Castration Resistant Prostate Cancer (CRPC) and\n* have previously received treatment for CRPC and have progressed from the last treatment\n\nAll participants in Part 3 of this study will receive mevrometostat and\u002F or enzalutamide. Part 3 consists of 2 sub studies each has an assessment phase and a maintenance phase. The Part 3 DDI substudy consist of 2 cohorts, Cohort 1 (monotherapy cohort) and Cohort 2 (Combination cohort).\n\nIn the assessment phase:\n\n* participants in the BE substudy will take 3 single doses of mevrometostat by mouth over 3 periods.\n* participants in the DDI substudy Cohort 1 (monotherapy cohort) will take mevrometostat 2 times a day and\u002For itraconazole 1 time a day based on a present schedule.\n* participants in the DDI substudy Cohort 2 (combination cohort) will take mevrometostat 2 times a day, enzalutamide 1 time a day, and\u002For itraconazole 1 time a day based on a present schedule.\n\nAfter completion of the assessment phase, participants will enter the maintenance phase where they will receive mevrometostat 2 times a day and enzalutamide 1 time a day by mouth until their cancer is no longer responding.\n\nThe study will look at the experiences of participanrs receiving the study medicine. This will help see if the study medicine is safe and effective.",[779,780,781],"Metastatic Castration Resistant Prostate Cancer (mCRPC)","Small Cell Lung Cancer (SCLC)","Follicular Lymphoma (FL)",[783,784,785,786,787,788,789,790,791,792,793,794,795,796,797,798,799,800],"EZH2","enhancer of zeste homolog 2","castrate resistant prostate cancer","prostatecancer-study.com","mCRPC","efficacy","safety","pharmacokinetics","pharmacodynamics","dose escalation","dose expansion","open-label","small cell lung cancer","SCLC","follicular lymphoma","FL","relapsed","refractory","2026-06-29",{"date":803,"type":804},"2026-07-01","ACTUAL",{"date":806,"type":804},"2018-04-17",{"date":808,"type":773},"2029-07-07",{"name":5,"class":6},83]