The goal of this clinical trial is to learn how a investigational medicinal product (THC) affects psychological and physical responses in healthy adults with prior cannabis use experience. The main questions it aims to answer are:
\- How do different dose levels of the investigational medicinal product (THC) influence short-term subjective and physiological responses?
Researchers will compare three dose levels of the study drug to a placebo (a look-alike substance with no active ingredient) to see how responses vary across sessions.
Participants will:
* Attend four in-person study visits, each involving a single dose of either the study drug or placebo * Complete questionnaires about their moment-to-moment experiences * Have their heart rate, blood pressure, and other physical measures monitored * Undergo serial blood sampling to measure circulating biomarkers
Adults aged 18-55
No major medical or psychiatric conditions
At least one previous, well-tolerated experience with cannabis
Not currently pregnant or breastfeeding
Family history (first- or second-degree relatives) of bipolar disorder, psychosis, or schizophrenia
Significant negative reaction to cannabis in the past or known allergy to cannabis products
Currently using recreational drugs