The purpose of this study is to establish the safety of novel dosing and ramp-up schedules for sonrotoclax in participants with hematological malignancies.
Stable Eastern Cooperative Oncology Group (ECOG) Performance Status ≤ 2.
Adequate organ function and no very recent transfusion or blood growth factor
Participants of childbearing potential must be willing to use a highly effective method of birth control and refrain from egg donation for the duration of the study and for ≥ 7 days after the last dose of sonrotoclax or 1 month after the last dose of zanubrutinib, whichever is later.
Confirmed diagnosis of CLL, based on Hallek et al 2018, and requiring treatment due to certain features of their disease
Participants unable to comply with the requirements of the protocol
Serologic status reflecting active viral hepatitis B virus (HBV) or hepatitis C virus (HCV) infection
Positive HIV serology (HIVAb) status unless certain conditions are met.
Participants with any major surgical procedure ≤ 28 days before first dose of study treatment