[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100642888":3},{"organization":4,"armGroups":7,"interventions":25,"overallOfficials":30,"centralContacts":39,"locations":45,"responsibleParty":60,"collaborators":30,"id":62,"slug":30,"hasResults":63,"nctId":64,"briefTitle":65,"officialTitle":66,"acronym":67,"eligibilityCriteria":68,"healthyVolunteers":69,"sex":70,"minAge":71,"maxAge":72,"enrollmentInfo":73,"targetDuration":30,"studyType":76,"phases":77,"briefSummary":79,"conditions":80,"keywords":86,"overallStatus":47,"whyStopped":30,"lastUpdateSubmitDate":92,"lastUpdatePostDateStruct":93,"startDateStruct":96,"completionDateStruct":98,"leadSponsor":100,"locationsCount":101},{"fullName":5,"class":6},"Ain Shams University","OTHER",[8,14,19],{"label":9,"type":10,"description":11,"interventionNames":12},"Calcium Silicate Intracanal Medication","EXPERIMENTAL","Calcium silicate-based bioceramic Intracanal Medication as Bio C-Temp (Angelus)",[13],"Drug: Calcium Silicate Intracanal Medication",{"label":15,"type":10,"description":16,"interventionNames":17},"Calcium Hydroxide Slurry mixed with Sodium Hypochlorite","Calcium Hydroxide slurry mixed with 3% Sodium Hypochlorite",[18],"Drug: Calcium Hydroxide Slurry mixed with Sodium Hypochlorite Intracanal Medication",{"label":20,"type":21,"description":22,"interventionNames":23},"Calcium Hydroxide","ACTIVE_COMPARATOR","Calcium Hydroxide Intracanal Medication (Control Group)",[24],"Drug: Calcium Hydroxide (Ca(OH)2) Intracanal Medication",[26,31,35],{"type":27,"name":9,"description":28,"armGroupLabels":29,"otherNames":30},"DRUG","Calcium silicate-based bioceramic materials have gained attention for their bioactivity and biocompatibility, acting through hydration with calcium hydroxide release followed by hydroxyapatite formation that promotes healing. Bio-C Temp is an example, characterized by high calcium ion release, alkaline pH, adequate radiopacity, and good biocompatibility.",[9],null,{"type":27,"name":32,"description":33,"armGroupLabels":34,"otherNames":30},"Calcium Hydroxide Slurry mixed with Sodium Hypochlorite Intracanal Medication","Combining calcium hydroxide with sodium hypochlorite (NaOCl) has been proposed. NaOCl provides rapid and potent antimicrobial and tissue-dissolving effects, while Ca(OH)₂ offers prolonged action. Both agents retain their properties when combined, and this combination may produce a synergistic effect that enhances disinfection and reduces chair time in two-visit treatment protocols.",[15],{"type":27,"name":36,"description":37,"armGroupLabels":38,"otherNames":30},"Calcium Hydroxide (Ca(OH)2) Intracanal Medication","Calcium hydroxide ICM being the most widely used due to its high alkalinity, antimicrobial properties, endotoxin neutralization, and ability to reduce periapical inflammation. It is applied as an aqueous mixture or polyethylene glycol-based paste and provides a slow but sustained antimicrobial effect. Despite their benefits, Ca(OH)₂ medicaments re limited by their solubility, susceptibility to tissue fluids, potential to weaken tooth structure over time, and reduced effectiveness against resistant microorganisms such as Candida Albicans and Enterococcus Faecalis.",[20],[40],{"name":41,"role":42,"phone":43,"phoneExt":30,"email":44},"Merna Mamdouh Botros Billatos, Msc","CONTACT","00201201579537","mernabotros@dent.asu.edu.eg",[46],{"facility":5,"status":47,"city":48,"state":30,"zip":30,"country":49,"countryCode":50,"cosmosGeoPoint":51,"geoPoint":56,"contacts":57},"RECRUITING","Cairo","Egypt","EG",{"type":52,"coordinates":53},"Point",[54,55],31.24967,30.06263,{"lat":55,"lon":54},[58],{"name":5,"role":42,"phone":59,"phoneExt":30,"email":30},"00201000397491",{"type":61,"investigatorFullName":30,"investigatorTitle":30,"investigatorAffiliation":30,"oldNameTitle":30,"oldOrganization":30},"SPONSOR","100642888",false,"NCT07641933","Biological, Radiographic and Clinical Evaluation of Various Inter-Visit Root Canal Dressings in Retreatment Cases","Biological, Radiographic and Clinical Evaluation of Various Inter-Visit Root Canal Dressings in Retreatment Cases: A Randomized Controlled Clinical Trial","RCT","Inclusion Criteria:\n\n1. Age: 21-45 years.\n2. Medically free patients. (ASA Class 1)\n3. Gender: males and females\n4. Patients who are cooperative at operation and in attendance at scheduled follow-up visits.\n5. Restorable root canal treated permanent lower first molars with periapical lesions.\n6. Small (\\\u003C5 mm) or medium periapical lesion size (5-10 mm)\n\nExclusion Criteria:\n\n1. Patients with a history of allergic reactions to any of the study materials.\n2. Teeth that become non-restorable after complete caries excavation.\n3. Teeth that have mobility or deep periodontal pockets.\n4. Teeth with internal or external resorption.",true,"ALL","21 Years","45 Years",{"count":74,"type":75},60,"ESTIMATED","INTERVENTIONAL",[78],"PHASE1","The aim of this clinical trial is to evaluate anti-inflammatory effect of various intracanal medications:\n\n1. Calcium Hydroxide Slurry mixed with 3% Sodium Hypochlorite\n2. Calcium Silicate\n3. Calcium Hydroxide\n\nIn retreatment cases in terms of:\n\n1. Biological Evaluation: Biomarker (IL 1B)\n2. Radiographic Evaluation: CBCT\n3. Clinical Evaluation: Pain Score (VAS)",[81,82,83,84,85],"Intervention Studies","ASA Physical Status I","Intracanal Medication","Periapical Abscess","Retreatment",[87,88,89,90,91],"intracanal medication","retreatment","inflammatory marker","radiographic","pain score","2026-06-10",{"date":94,"type":95},"2026-06-12","ACTUAL",{"date":97,"type":95},"2026-06-01",{"date":99,"type":75},"2027-08",{"name":5,"class":6},1]