Feasibility and Safety of Ketamine for Suicidal Patients in the Emergency Department
Trial statusRecruiting
Trial phasePhase 1
Trial typeInterventional
Biological sexAll
Age18-65
SponsorLindsay Maguire, MD
About this trial
There is currently no readily available pharmacologic intervention for suicidal ideation, a true psychiatric emergency, in the Emergency Department (ED). Investigators aim to trial low-dose, intravenous ketamine, a drug with well-established use in treatment-resistant depression, for patients who present to the ED with suicidal ideation.
Eligibility criteria
Qualifiers
Acutely Suicidality ("yes" answer to any of items 4 or 5 on C-SSRS "Suicidal Ideation" category)
Require inpatient stabilization for SI or actions based on clinical observation and interview
Are accepted for psychiatric stabilization at the University of Kansas Medical Center's Strawberry Hill campus
Have a Glasgow Coma Score (GCS) of 15
Disqualifiers
Current or past history of psychosis
Current or recent (past 4 weeks) symptoms of mania/hypomania as defined by Young Mania Rating Scale (YRMS) score of 12 or greater
History of ketamine use disorder
History of liver transplant
Trial design
Treatments tested in this trial
- Ketamine
Treatment groups
50 Participants
are divided into 1 treatment groupSponsors and collaborators
Lindsay Maguire, MD
Lead sponsor
University of Kansas Medical Center
Sponsor institution
Source ClinicalTrials.gov