[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100595828":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":20,"centralContacts":20,"locations":21,"responsibleParty":49,"collaborators":51,"id":54,"slug":20,"hasResults":55,"nctId":56,"briefTitle":57,"officialTitle":58,"acronym":59,"eligibilityCriteria":60,"healthyVolunteers":55,"sex":61,"minAge":62,"maxAge":20,"enrollmentInfo":63,"targetDuration":20,"studyType":66,"phases":67,"briefSummary":70,"conditions":71,"keywords":73,"overallStatus":76,"whyStopped":20,"lastUpdateSubmitDate":77,"lastUpdatePostDateStruct":78,"startDateStruct":81,"completionDateStruct":83,"leadSponsor":85,"locationsCount":86},{"fullName":5,"class":6},"Hospital do Coracao","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Single arm","EXPERIMENTAL","Low Dose Radiotherapy",[13],"Radiation: Radiation Therapy",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":20},"RADIATION","Radiation Therapy","Low single-dose wholw-heart radiotherapy",[9],null,[22],{"facility":23,"status":20,"city":24,"state":20,"zip":25,"country":26,"countryCode":27,"cosmosGeoPoint":28,"geoPoint":33,"contacts":34},"Hcor \u002F Associação Beneficente Síria","São Paulo","04004-030","Brazil","BR",{"type":29,"coordinates":30},"Point",[31,32],-46.63611,-23.5475,{"lat":32,"lon":31},[35,40,43,46],{"name":36,"role":37,"phone":38,"phoneExt":20,"email":39},"Alexandre B Cavalcanti, MD, Ph.D","CONTACT","55 11 3053-6611","abiasi@hcor.com.br",{"name":41,"role":37,"phone":38,"phoneExt":20,"email":42},"Tamiris A Miranda, RPh, M.Sc","tabait@hcor.com.br",{"name":44,"role":45,"phone":20,"phoneExt":20,"email":20},"Douglas G Castro, MD, Ph.D","PRINCIPAL_INVESTIGATOR",{"name":47,"role":48,"phone":20,"phoneExt":20,"email":20},"Alexandre M Soeiro, MD, Ph.D","SUB_INVESTIGATOR",{"type":50,"investigatorFullName":20,"investigatorTitle":20,"investigatorAffiliation":20,"oldNameTitle":20,"oldOrganization":20},"SPONSOR",[52],{"name":53,"class":6},"Financiadora de Estudos e Projetos","100595828",false,"NCT07037524","Low Dose Radiotherapy for Heart Failure","Prospective Pilot Single-center Study to Evaluate the Safety and Efficacy of Low-dose Radiotherapy in Patients With Heart Failure","RadioCardio","Inclusion Criteria\n\n* Age \\>18 years;\n* Clinical and laboratory diagnosis of chronic systolic HF grades II or III of the New York Heart Association with ejection fraction \\\u003C40%;\n* Refractoriness to standard clinical treatment; defined as the persistence of HF signs and symptoms despite optimized drug therapy.\n* Patient consent to participate in the study.\n* Agreement to adopt contraceptive practices\u002Fmethods until the end of the intervention for women of childbearing age.\n\nExclusion Criteria\n\n* Patients who have undergone any type of previous radiotherapy in the thoracic region;\n* Patients who have undergone heart transplants;\n* Contraindications for magnetic resonance imaging (MRI), such as the use of metal implants or prostheses.\n* Pregnant patients.","ALL","18 Years",{"count":64,"type":65},10,"ESTIMATED","INTERVENTIONAL",[68,69],"PHASE1","PHASE2","The primary goals of this clinical trial are to evaluate the safety and efficacy of a low dose whole-heart radiotherapy with a single fraction in ten participants with advanced heart failure.",[72],"Heart Failure - NYHA II - IV",[74,75],"Heart Failure","Radiotherapy","NOT_YET_RECRUITING","2025-06-24",{"date":79,"type":80},"2025-06-25","ACTUAL",{"date":82,"type":65},"2025-07-14",{"date":84,"type":65},"2030-09-30",{"name":5,"class":6},1]