[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100628525":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":30,"centralContacts":35,"locations":41,"responsibleParty":56,"collaborators":25,"id":59,"slug":25,"hasResults":60,"nctId":61,"briefTitle":62,"officialTitle":63,"acronym":64,"eligibilityCriteria":65,"healthyVolunteers":60,"sex":66,"minAge":67,"maxAge":25,"enrollmentInfo":68,"targetDuration":25,"studyType":71,"phases":72,"briefSummary":75,"conditions":76,"keywords":81,"overallStatus":88,"whyStopped":25,"lastUpdateSubmitDate":89,"lastUpdatePostDateStruct":90,"startDateStruct":93,"completionDateStruct":95,"leadSponsor":97,"locationsCount":98},{"fullName":5,"class":6},"Louisiana State University Health Sciences Center in New Orleans","OTHER",[8,15],{"label":9,"type":10,"description":11,"interventionNames":12},"Sequence A: Probiotic then Blueberry Extract","EXPERIMENTAL","Participants receive probiotic for 4 weeks, washout 6 weeks, then blueberry extract for 4 weeks.",[13,14],"Dietary Supplement: Limosilactobacillus reuteri","Dietary Supplement: Blueberry extract",{"label":16,"type":10,"description":17,"interventionNames":18},"Sequence B: Blueberry Extract then Probiotic","Participants receive blueberry extract for 4 weeks, washout 6 weeks, then probiotic for 4 weeks.",[13,14],[20,26],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"DIETARY_SUPPLEMENT","Limosilactobacillus reuteri","Administered as 6 capsules daily (3 twice daily) for 4 weeks. Each daily dose contains 1×10\\^10 CFU total in a 1:1 ratio of two strains. This is a GRAS dietary supplement and not an FDA-regulated investigational product.",[9,16],null,{"type":21,"name":27,"description":28,"armGroupLabels":29,"otherNames":25},"Blueberry extract","Administered as 6 capsules daily (3 twice daily) for 4 weeks, providing 500 mg anthocyanins per day. This is a GRAS dietary supplement and not an FDA-regulated investigational product.",[9,16],[31],{"name":32,"affiliation":33,"role":34},"David A Welsh, MD","LSU Health New Orleans","PRINCIPAL_INVESTIGATOR",[36],{"name":32,"role":37,"phone":38,"phoneExt":39,"email":40},"CONTACT","United States","5045684634","dwelsh@lsuhsc.edu",[42],{"facility":43,"status":25,"city":44,"state":45,"zip":46,"country":38,"countryCode":47,"cosmosGeoPoint":48,"geoPoint":53,"contacts":54},"LSU Health","New Orleans","Louisiana","70112","US",{"type":49,"coordinates":50},"Point",[51,52],-90.07507,29.95465,{"lat":52,"lon":51},[55],{"name":32,"role":37,"phone":38,"phoneExt":39,"email":40},{"type":34,"investigatorFullName":57,"investigatorTitle":58,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"David Welsh","Professor","100628525",false,"NCT07462767","Precision Microbiota Interventions for Senoreduction Trial","Geroprotective Precision Medicine Strategies in PWH That Use Alcohol","PreMIS","Inclusion Criteria:\n\n* Age ≥40 years\n* People with HIV\n* Recent alcohol use defined as ≥42 grams in the prior week and positive urine ethyl glucuronide (EtG)\n\nExclusion Criteria:\n\n* Probiotic use in past 3 months\n* Recent antibiotics or immunosuppressives\n* Allergy to study products\n* Pregnancy or breastfeeding\n* Inability to comply","ALL","40 Years",{"count":69,"type":70},160,"ESTIMATED","INTERVENTIONAL",[73,74],"PHASE1","PHASE2","People with HIV who drink alcohol are at increased risk for accelerated aging biology, including increased immune senescence. This randomized, double-blind, crossover clinical trial evaluates two generally recognized as safe (GRAS) microbiota-targeted interventions on immune senescence biomarkers.",[77,78,79,80],"HIV Infections","Alcohol Drinking","Aging","Immunosenescence",[82,83,80,84,85,86,27,87],"People with HIV","Alcohol use","Senescence","Microbiome","Probiotic","Crossover trial","NOT_YET_RECRUITING","2026-03-05",{"date":91,"type":92},"2026-03-10","ACTUAL",{"date":94,"type":70},"2026-04-01",{"date":96,"type":70},"2029-12-01",{"name":5,"class":6},1]