[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100054074":3},{"organization":4,"armGroups":7,"interventions":31,"overallOfficials":57,"centralContacts":61,"locations":68,"responsibleParty":81,"collaborators":42,"id":83,"slug":42,"hasResults":84,"nctId":85,"briefTitle":86,"officialTitle":87,"acronym":88,"eligibilityCriteria":89,"healthyVolunteers":84,"sex":90,"minAge":91,"maxAge":92,"enrollmentInfo":93,"targetDuration":42,"studyType":96,"phases":97,"briefSummary":100,"conditions":101,"keywords":104,"overallStatus":71,"whyStopped":42,"lastUpdateSubmitDate":112,"lastUpdatePostDateStruct":113,"startDateStruct":116,"completionDateStruct":118,"leadSponsor":120,"locationsCount":121},{"fullName":5,"class":6},"Novartis","INDUSTRY",[8,14,19,23,27],{"label":9,"type":10,"description":11,"interventionNames":12},"Group 1: opnurasib single agent","EXPERIMENTAL","Eligible participants will receive the same starting dose and regimen of opnurasib as the last dose and regimen administered before completing the parent protocol at the time of transition to the rollover study.",[13],"Drug: Opnurasib",{"label":15,"type":10,"description":16,"interventionNames":17},"Group 2: opnurasib + TNO155","Eligible participants will receive the same starting dose and regimen of opnurasib and any applicable combination drug as the last dose and regimen administered before completing the parent protocol at the time of transition to the rollover study.",[13,18],"Drug: TNO155",{"label":20,"type":10,"description":16,"interventionNames":21},"Group 3: opnurasib + trametinib",[13,22],"Drug: trametinib",{"label":24,"type":10,"description":16,"interventionNames":25},"Group 4: opnurasib + cetuximab",[13,26],"Biological: cetuximab",{"label":28,"type":10,"description":16,"interventionNames":29},"Group 5: opnurasib + tislelizumab",[13,30],"Biological: tislelizumab",[32,38,43,48,52],{"type":33,"name":34,"description":11,"armGroupLabels":35,"otherNames":36},"DRUG","Opnurasib",[9,15,20,24,28],[37],"JDQ443",{"type":33,"name":39,"description":40,"armGroupLabels":41,"otherNames":42},"TNO155","Eligible participants will receive the same starting dose and regimen of any applicable combination drug as the last dose and regimen administered before completing the parent protocol at the time of transition to the rollover study.",[15],null,{"type":33,"name":44,"description":40,"armGroupLabels":45,"otherNames":46},"trametinib",[20],[47],"TMT212",{"type":49,"name":50,"description":40,"armGroupLabels":51,"otherNames":42},"BIOLOGICAL","cetuximab",[24],{"type":49,"name":53,"description":40,"armGroupLabels":54,"otherNames":55},"tislelizumab",[28],[56],"VDT482",[58],{"name":59,"affiliation":59,"role":60},"Novartis Pharmaceuticals","STUDY_DIRECTOR",[62,66],{"name":59,"role":63,"phone":64,"phoneExt":42,"email":65},"CONTACT","+41613241111","novartis.email@novartis.com",{"name":59,"role":63,"phone":67,"phoneExt":42,"email":65},"+81337978748",[69],{"facility":70,"status":71,"city":72,"state":42,"zip":73,"country":74,"countryCode":42,"cosmosGeoPoint":75,"geoPoint":80,"contacts":42},"Novartis Investigative Site","RECRUITING","Seoul","03080","South Korea",{"type":76,"coordinates":77},"Point",[78,79],126.9784,37.566,{"lat":79,"lon":78},{"type":82,"investigatorFullName":42,"investigatorTitle":42,"investigatorAffiliation":42,"oldNameTitle":42,"oldOrganization":42},"SPONSOR","100054074",false,"NCT07468071","Rollover Study for Participants Who Have Been Treated With and Are Continuing to Benefit From Opnurasib as a Single Agent or in Combination With Other Study Treatments","KontRASt-R: An Open-label, Multi-center, Rollover Study for Participants Who Have Been Previously Enrolled Into a Novartis-sponsored Opnurasib (JDQ443) Study and Are Continuing to Benefit From Opnurasib as a Single Agent or in Combination With Other Study Treatments","KontRASt-R","Key Inclusion Criteria:\n\n* Participant is currently enrolled in a pre-defined Novartis-sponsored study and is receiving opnurasib as single agent or in combination with other study treatment.\n* Participant has received at least 6 cycles of opnurasib in a parent study.\n* Participant is currently deriving clinical benefit from the study treatment, as determined by the Investigator.\n* Participants currently receiving treatment in one of the KontRASt studies, including those who have not experienced disease progression or who are continuing treatment beyond initial disease progression, may be eligible to enroll in the rollover study if, in the Investigator's judgment, they are expected to continue deriving clinical benefit from treatment with opnurasib (alone or in combination). Clinical benefit, as assessed by the Investigator, may be reflected by delayed disease progression, improvement in disease-related symptoms, improvement in overall quality of life, or a combination of these factors.\n\nKey Exclusion Criteria:\n\n* Participant has been permanently discontinued from opnurasib in the parent protocol for any reason other than enrollment in the CJDQ443B12105B study.\n* Participant is not willing to comply with the contraception requirements outlined in the exclusion criteria of the parent protocol.\n* Participant currently has unresolved toxicities for which opnurasib dosing has been interrupted in the parent study.\n* Participant has known actionable mutations, such as EGFR-sensitizing mutation, ALK rearrangement, or others, identified during the participation in the parent trial for which there are available treatment options.\n\nOther protocol-defined inclusion\u002Fexclusion criteria may apply.","ALL","18 Years","100 Years",{"count":94,"type":95},40,"ESTIMATED","INTERVENTIONAL",[98,99],"PHASE1","PHASE2","The purpose of this study is to allow continued access to opnurasib (JDQ443) to participants who are benefitting from treatment with opnurasib as a single agent or in combination with other study treatments in pre-defined Novartis-sponsored opnurasib studies and to continue to assess safety in these participants.",[102,103],"Locally Advanced or Metastatic KRAS G12C-mutated Non-small Cell Lung Cancer","Advanced Solid Tumors Harboring the KRAS G12C Mutation",[105,106,107,108,109,39,110,50,111],"KRAS G12C","non-small cell lung cancer (NSCLC)","colorectal cancer (CRC)","advanced solid tumors","opnurasib (JDQ443)","trametinib (TMT212)","tislelizumab (VDT482)","2026-07-10",{"date":114,"type":115},"2026-07-13","ACTUAL",{"date":117,"type":115},"2026-06-08",{"date":119,"type":95},"2029-09-17",{"name":59,"class":6},1]