THC Effects on Glucose in Type 2 Diabetes
ConditionType 2 Diabetes
Trial statusRecruiting
Trial phasePhase 1
Trial typeInterventional
Biological sexAll
Age21-70
SponsorUniversity of California, San Diego
About this trial
This study will examine the effects THC has on Glucose Metabolism and Endothelial Functioning in participants with Type 2 Diabetes. The participants will complete blood tests and tests to measure energy expenditure, CVD risks, and glucose metabolism. These tests will be performed prior to start of treatment and again after 2-weeks of treatment with the THC or placebo.
Eligibility criteria
Qualifiers
Males and Females 21-70 years old at the time of screening.
Females of non-child bearing potential must be ≥ 1 year post-menopausal or documented as being surgically sterile. Females of child bearing potential must agree to use two methods of contraception during the entire study.
Male subjects must be willing to use clinically acceptable method of contraception during the entire study.
Have a clinical diagnosis of Type 2 Diabetes on a stable medication regimen for at least 3 months.
Disqualifiers
History or presence of any clinically significant illness, as detected by history, physical examination, and/or laboratory tests, that might put the participant at increased risk of adverse events (e.g., history of psychotic disorder, clinically significant mood and/or anxiety disorder, liver, or renal disease).
No prior history of myocardial infarction, stroke or heart failure.
Whole blood donation of 1 pint (500 mL) within 8 weeks prior to Screening. Donations of plasma, packed RBCs, platelets or quantities less than 500 mL are allowed at investigator discretion.
Hemoglobin < 9g/dL.
Trial design
Treatments tested in this trial
- THC
- Placebo
Treatment groups
30 Participants
are divided into 2 treatment groupsSponsors and collaborators
University of California, San Diego
Lead sponsor
Center for Medicinal Cannabis Research
Collaborator
Source ClinicalTrials.gov