This phase II trial investigates how well 177Lu-DOTATATE works in treating patients with breast cancer that is stage IV or has come back (recurrent). 177Lu-DOTATATE may shrink or destroy the tumor or circulating breast cancer stem cells if they show evidence of the SSTR2. 177Lu-DOTATATE is a targeted therapy that uses DOTATATE, linked to a radioactive agent called 177Lu. DOTATATE attaches to tumor cells with SSTR2 and delivers 177Lu to kill them. Giving 177Lu-DOTATATE may help decrease the number and size of tumors and the number of circulating cancer stem cells in patient's blood for the treatment of patients with breast cancer positive for SSTR2.
Life expectancy of > 6 months, as determined by the investigator
Ability to understand and the willingness to sign a written informed consent document
Patients aged >= 18-100 years old at time of informed consent
Histologically or cytologically confirmed metastatic breast carcinoma
Currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within 4 weeks of first dose of 177Lu- DOTATATE treatment
Individuals in the follow-up phase of a prior investigational study may participate as long as it has been 4 weeks since last dose of the previous investigational agent or device
Prior external beam radiation therapy to more than 25% of the bone marrow
Other malignancy unless curatively treated with no evidence of disease for >= 5 years except: adequately treated non-melanoma skin cancer or curatively treated in situ cancer of the cervix
OHSU Knight Cancer Institute
Lead sponsor
Advanced Accelerator Applications
Collaborator
Oregon Health and Science University
Collaborator
Novartis Pharmaceuticals
Collaborator