A Multicenter Single-arm Prospective Clinical Study on First-line Treatment of Pancreatic Cancer Liver Metastases With Arterial Infusion Chemotherapy and Embolization Combined With Dual Immune Checkpoint Inhibitors.

Trial statusNot yet recruiting
Trial phasePhase 2
Trial typeInterventional
Biological sexAll
Age18-75
SponsorShandong Provincial Hospital

About this trial

To evaluate the efficacy of arterial infusion chemotherapy and embolization combined with iparplidutol-volerilis (QL1706) as first-line treatment for pancreatic cancer liver metastases based on progression-free survival (PFS).

Eligibility criteria

Qualifiers

1. Voluntarily participate in this study, sign the informed consent form, demonstrate good compliance, and cooperate with follow-up visits.

Absolute neutrophil count (ANC) ≥1.5×10⁹/L (without G-CSF support within 14 days).

Platelets ≥100×10⁹/L (without transfusion within 14 days).

Hemoglobin >9 g/dL (without transfusion or erythropoietin use within 14 days).

Disqualifiers

**Subjects meeting any of the following criteria will be excluded from this study:**

Diagnosis of another malignancy within 5 years prior to the first dose, unless cured (exceptions include radically treated basal cell carcinoma of the skin, squamous cell carcinoma of the skin, and/or carcinoma in situ that has undergone radical resection).

Currently participating in an interventional clinical study or having received other investigational drugs or devices within 4 weeks prior to the first dose.

Prior therapy with anti-PD-1, anti-PD-L1, anti-PD-L2 agents, or drugs targeting another stimulatory or co-inhibitory T-cell receptor (e.g., CTLA-4, OX-40, CD137).

Trial design

Treatments tested in this trial

  • Interventional
  • Targeted Therapy (anti-VEGF)
  • Immunotherapy + Targeted Therapy
  • Immunotherapy + Targeted Therapy + Chemotherapy
  • This cycle is repeated every 21 days.

Treatment groups

38 Participants
are divided into 1 treatment group

Locations

This trial has no locations

Sponsors and collaborators