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Is a male or female of non-childbearing potential between the ages of 18 and 83 years.\n2. Has a diagnosis of PH-HFpEF based on baseline echocardiogram and right heart catheterization (RHC).\n3. Has NYHA functional class II- III heart failure.\n4. Has 6MWT distance from 100 to 450m.\n5. Chronic medication for heart failure or cardiovascular disease is at a stable dose prior to screening.\n6. Is able to understand and provide documented consent for participation.\n\nExclusion Criteria:\n\n1. Diagnosis of PH in World Health Organization (WHO) Group 1, WHO Group 3, WHO Group 4, or WHO Group 5.\n2. Current or recent hospitalization prior to screening.\n3. Recently received vasoactive drugs, pulmonary arterial hypertension-specific therapies, or a relaxin receptor agonist.\n4. Initiated a new exercise program for cardiopulmonary rehabilitation or plans to initiate such a program during the study.\n5. Has a body mass index \\\u003C18 kg\u002Fmeter square or \\>45 kg\u002F meter square.\n6. Was previously administered TX000045, relaxin, or a relaxin fusion protein.\n7. Historical or current evidence of a clinically significant disease or disorder such as significant lung disease, cardiovascular comorbitiies, liver disease, infectious disease, or malignancy.\n8. Has any of the following clinical laboratory values during screening:\n\n   1. Serum alanine aminotransferase or aspartate aminotransferase levels \\> 3 x the upper limit of normal (ULN) or total bilirubin \\> 3 x ULN;\n   2. eGFR \\\u003C30 mL\u002Fmin\u002F1.73 m2;\n   3. HbA1c (glycosylated hemoglobin) \\>9%;\n   4. Platelet count \\\u003C50,000\u002Fmillimeter cube;\n   5. Hemoglobin \\\u003C10.0g\u002FdL;\n9. History of hypersensitivity or reactions to drugs with a similar chemical structure or class to TX000045.\n10. Is pregnant or breastfeeding.\n11. Has a history of cancer within 5 years of screening other than basal cell carcinoma, cervical carcinoma, or squamous cell carcinomas of the skin.\n12. 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