[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100372932":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":33,"centralContacts":37,"locations":43,"responsibleParty":60,"collaborators":32,"id":63,"slug":32,"hasResults":64,"nctId":65,"briefTitle":66,"officialTitle":67,"acronym":68,"eligibilityCriteria":69,"healthyVolunteers":64,"sex":70,"minAge":71,"maxAge":32,"enrollmentInfo":72,"targetDuration":32,"studyType":75,"phases":76,"briefSummary":78,"conditions":79,"keywords":81,"overallStatus":45,"whyStopped":32,"lastUpdateSubmitDate":83,"lastUpdatePostDateStruct":84,"startDateStruct":87,"completionDateStruct":89,"leadSponsor":91,"locationsCount":92},{"fullName":5,"class":6},"Brown University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"doxazosin","EXPERIMENTAL","16 mg, or maximum tolerated dose (MTD)",[13],"Drug: Doxazosin",{"label":15,"type":16,"description":17,"interventionNames":18},"placebo","PLACEBO_COMPARATOR","matching placebo",[19],"Drug: Placebo",[21,28],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DRUG","Doxazosin","16 mg or maximum tolerated dose (MTD)",[9],[27],"Cardura",{"type":22,"name":29,"description":30,"armGroupLabels":31,"otherNames":32},"Placebo","Matching placebo",[15],null,[34],{"name":35,"affiliation":5,"role":36},"Carolina L Haass-Koffler, PHARMD, PHD","PRINCIPAL_INVESTIGATOR",[38],{"name":39,"role":40,"phone":41,"phoneExt":32,"email":42},"Zoe L Brown, BA","CONTACT","401-863-6646","alcohol.stress.study@brown.edu",[44],{"facility":5,"status":45,"city":46,"state":47,"zip":48,"country":49,"countryCode":50,"cosmosGeoPoint":51,"geoPoint":56,"contacts":57},"RECRUITING","Providence","Rhode Island","20923","United States","US",{"type":52,"coordinates":53},"Point",[54,55],-71.41283,41.82399,{"lat":55,"lon":54},[58],{"name":59,"role":40,"phone":41,"phoneExt":32,"email":32},"Zoe Brown",{"type":36,"investigatorFullName":61,"investigatorTitle":62,"investigatorAffiliation":5,"oldNameTitle":32,"oldOrganization":32},"Carolina L Haass-Koffler","Assistant Professor","100372932",false,"NCT04135846","Alpha-1 Blockade for Alcohol Use Disorder (AUD)","A Focus on Alpha-1 Blockade as a Novel Pharmacological Treatment for AUD","DOXY","Inclusion Criteria:\n\n* Male or female, 18 years of age\n* Meet the DSM-5 criteria for AUD\n* Desire to reduce or quit alcohol drinking\n* Breath alcohol (BrAC) = 0.00 at each visit\n* In good health as confirmed by medical history, physical examination and lab tests\n* Willing to adhere to the study procedures\n* Understand informed consent and questionnaires in English at an 8th grade level\n\nExclusion Criteria:\n\n* Women who are breastfeeding or \u002Fpositive urine test for pregnancy\n* CrCl\\\u003C60mL\u002Fmin\n* Suicide attempt in the last three months\n* Current diagnosis of other substance disorder other than nicotine as assessed by self-report and urine toxicology screen at baseline\n* Current use of medication that may interact with doxazosin and\u002For yohimbine\n* History of allergy to any alpha receptor blockers\n* Clinical Institute Withdrawal Assessment for Alcohol revised (CIWA-Ar) score ≥ 8\n* Treatment with disulfiram, naltrexone, acamprosate, topiramate within 1 month prior to screening\n* Treatment with any alpha-blocker\n* Individuals with cardiac heat failure (CHF), as assessed by the medical history, the physical exam and the ECG.\n* Baseline hypotension defined as BP reading lower than 90\u002F60 mmHg\n* Use of phosphodiesterase inhibitors (PDE5) erectile dysfunction medication","ALL","18 Years",{"count":73,"type":74},184,"ESTIMATED","INTERVENTIONAL",[77],"PHASE2","The goal of this research is to replicate findings previously conducted in a pilot trial and to understand, mechanistically, the role of stress in the development of AUD pharmacotherapies that target noradrenergic blockade.",[80],"Alcohol Use Disorder (AUD)",[82],"Alcohol use disorder, stress","2026-03-18",{"date":85,"type":86},"2026-03-20","ACTUAL",{"date":88,"type":86},"2019-12-19",{"date":90,"type":74},"2026-08-31",{"name":5,"class":6},1]