[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100570086":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":28,"centralContacts":32,"locations":41,"responsibleParty":60,"collaborators":11,"id":63,"slug":11,"hasResults":64,"nctId":65,"briefTitle":66,"officialTitle":67,"acronym":68,"eligibilityCriteria":69,"healthyVolunteers":64,"sex":70,"minAge":71,"maxAge":11,"enrollmentInfo":72,"targetDuration":11,"studyType":75,"phases":76,"briefSummary":79,"conditions":80,"keywords":82,"overallStatus":44,"whyStopped":11,"lastUpdateSubmitDate":85,"lastUpdatePostDateStruct":86,"startDateStruct":89,"completionDateStruct":91,"leadSponsor":93,"locationsCount":94},{"fullName":5,"class":6},"The University of Texas Health Science Center, Houston","OTHER",[8,15],{"label":9,"type":10,"description":11,"interventionNames":12},"Treatment with Diphenhydramine","EXPERIMENTAL",null,[13,14],"Drug: Treatment with Diphenhydramine","Combination Product: Usual Care",{"label":16,"type":17,"description":11,"interventionNames":18},"Usual Care","ACTIVE_COMPARATOR",[14],[20,24],{"type":21,"name":9,"description":22,"armGroupLabels":23,"otherNames":11},"DRUG","Diphenhydramine 50mg IV will be administered within 1 hour of the cervical exam which diagnosed prolonged active phase of labor",[9],{"type":25,"name":16,"description":26,"armGroupLabels":27,"otherNames":11},"COMBINATION_PRODUCT","Participants will receive cervical exams every 2 hours in active labor, placement of intrauterine pressure catheter, up titration of Pitocin if contractions are inadequate, maternal repositioning, and use of adjunct devices such as a peanut ball.",[9,16],[29],{"name":30,"affiliation":5,"role":31},"Samantha Antonioli, MD","PRINCIPAL_INVESTIGATOR",[33,37],{"name":30,"role":34,"phone":35,"phoneExt":11,"email":36},"CONTACT","(713) 566-5735","Samantha.Hentosh@uth.tmc.edu",{"name":38,"role":34,"phone":39,"phoneExt":11,"email":40},"Aaron Roberts","(713) 500-6412","Aaron.W.Roberts@uth.tmc.edu",[42],{"facility":43,"status":44,"city":45,"state":46,"zip":47,"country":48,"countryCode":49,"cosmosGeoPoint":50,"geoPoint":55,"contacts":56},"The University of Texas Health Science Center at Houston","RECRUITING","Houston","Texas","77030","United States","US",{"type":51,"coordinates":52},"Point",[53,54],-95.36327,29.76328,{"lat":54,"lon":53},[57,59],{"name":30,"role":34,"phone":58,"phoneExt":11,"email":36},"713-566-5735",{"name":38,"role":34,"phone":39,"phoneExt":11,"email":40},{"type":31,"investigatorFullName":61,"investigatorTitle":62,"investigatorAffiliation":5,"oldNameTitle":11,"oldOrganization":11},"Samantha Antonioli","Resident","100570086",false,"NCT06702670","Anticholinergics for Cervical Edema in Labor","Anticholinergics for Cervical Edema in Labor (ACCEL)","ACCEL","Inclusion Criteria:\n\n* Primiparous\n* Viable single intrauterine pregnancy\n\n  -≥ 34 weeks of gestation\n* Ruptured membranes\n* Category I tracing at time of inclusion\n* Active phase of labor (\\>=6 cm of cervix dilation)\n\nExclusion Criteria:\n\n* Category II or III tracing\n* Allergy to the study medication (IV Diphenhydramine)","FEMALE","18 Years",{"count":73,"type":74},200,"ESTIMATED","INTERVENTIONAL",[77,78],"PHASE2","PHASE3","The purpose of this study is to is to determine the clinical effectiveness of a single dose of intravenous (IV) medication for the prevention of labor arrest and cesarean delivery in primiparous women undergoing trial of labor.",[81],"Labor Dystocia",[83,84],"dilation","labor","2026-05-04",{"date":87,"type":88},"2026-05-06","ACTUAL",{"date":90,"type":88},"2025-03-25",{"date":92,"type":74},"2027-04-09",{"name":5,"class":6},1]