Combination Therapy for Alcohol Use Disorder

ConditionAlcohol Use Disorder

Trial statusNot yet recruiting

Trial phasePhase 2

Trial typeInterventional

Biological sexAll

Age21-65

SponsorJohns Hopkins University

About this trial

This human laboratory study will collect preliminary safety and efficacy data from a sample of participants enrolled in a 4-week in-patient treatment program for alcohol use disorder.

Eligibility criteria

Qualifiers

Aged 21-65 years old

Enrolled at Ashley Addiction Treatment center at least one week prior to beginning study participation.

Meet the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition, Text Revision (DSM-5-TR) criteria for Alcohol Use Disorder

Willing to comply with the study protocol

Disqualifiers

Score 9 or greater on the Clinical Institute Withdrawal Assessment for Alcohol-Revised (CIWA-Ar) at randomization

Currently pregnant, breastfeeding

Unwilling to use contraceptives (e.g., condoms and/or hormonal birth control)

Meet criteria for another substance use disorder other than AUD, Tobacco Use Disorder, or Caffeine use disorder

Trial design

Treatments tested in this trial

Placebo
Glucagon-Like Peptide-1 Agonist (GLP-1)
Naltrexone (oral tablets)

Treatment groups

45 Participants

are divided into 3 treatment groups

Sponsors and collaborators

Johns Hopkins University

Lead sponsor

Source ClinicalTrials.gov