Consolidation Versus Induction Chemotherapy in Total Neoadjuvant Therapy of Rectal Cancer With High Risk for Recurrence

ConditionLocally Advanced Rectal Cancer

Trial statusRecruiting

Trial phasePhase 2

Trial typeInterventional

Biological sexAll

Age18+

SponsorInstitute of Oncology Ljubljana

About this trial

The purpose of the study is to identify the most promising sequence of modalities in total neoadjuvant treatment of localy advanced rectal cancer with high risk of recurrence

Eligibility criteria

Qualifiers

histologically proven rectal adenocarcinoma

no distant metastases on CT scan (M0 disease)

T4 tumor (cT4)

N2 disease (cN2)

Disqualifiers

absolute contraindications for MR imaging

distant metastases cannot be reliably excluded

synchronous cancer

chronic inflammatory bowel disease

Trial design

Treatments tested in this trial

consolidation chemotherapy
induction chemotherapy

Treatment groups

62 Participants

are divided into 2 treatment groups

Sponsors and collaborators

Institute of Oncology Ljubljana

Lead sponsor

Source ClinicalTrials.gov