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64",{"type":71,"coordinates":1261},[1262,1263],18.00086,59.36004,{"lat":1263,"lon":1262},[1266],{"name":78,"role":57,"phone":1267,"phoneExt":59,"email":59},"+46812373124",{"facility":1269,"status":64,"city":1270,"state":1271,"zip":1272,"country":1273,"countryCode":1274,"cosmosGeoPoint":59,"geoPoint":59,"contacts":1275},"Faculty of Medicine Siriraj Hospital ( Site 3200)","Bangkoknoi","Bangkok","10700","Thailand","TH",[1276],{"name":78,"role":57,"phone":1277,"phoneExt":59,"email":59},"+6624197000",{"facility":1279,"status":522,"city":1280,"state":1281,"zip":1282,"country":1273,"countryCode":1274,"cosmosGeoPoint":59,"geoPoint":59,"contacts":59},"Faculty of Medicine - Khon Kaen University ( Site 3202)","Muang","Changwat Khon Kaen","40002",{"facility":1284,"status":64,"city":1285,"state":59,"zip":1286,"country":1273,"countryCode":1274,"cosmosGeoPoint":1287,"geoPoint":1291,"contacts":1292},"Maharaj Nakorn Chiang Mai Hospital-Department of Pediatrics ( Site 3201)","Chiang Mai","50200",{"type":71,"coordinates":1288},[1289,1290],98.98468,18.79038,{"lat":1290,"lon":1289},[1293],{"name":78,"role":57,"phone":1294,"phoneExt":59,"email":59},"+66834739974",{"facility":1296,"status":64,"city":1297,"state":59,"zip":1298,"country":1299,"countryCode":59,"cosmosGeoPoint":1300,"geoPoint":1304,"contacts":1305},"Hacettepe Universite Hastaneleri ( Site 3304)","Ankara","06230","Turkey (Türkiye)",{"type":71,"coordinates":1301},[1302,1303],32.85427,39.91987,{"lat":1303,"lon":1302},[1306],{"name":78,"role":57,"phone":1307,"phoneExt":59,"email":59},"+90 (0312) 305 25 85",{"facility":1309,"status":64,"city":1297,"state":59,"zip":1310,"country":1299,"countryCode":59,"cosmosGeoPoint":1311,"geoPoint":1313,"contacts":1314},"Baskent Universitesi Ankara Hastanesi ( Site 3301)","06490",{"type":71,"coordinates":1312},[1302,1303],{"lat":1303,"lon":1302},[1315],{"name":78,"role":57,"phone":1316,"phoneExt":59,"email":59},"+90 (312) 246 66 66",{"facility":1318,"status":64,"city":1297,"state":59,"zip":1319,"country":1299,"countryCode":59,"cosmosGeoPoint":1320,"geoPoint":1322,"contacts":1323},"Ankara Bilkent Şehir Hastanesi. ( Site 3300)","06800",{"type":71,"coordinates":1321},[1302,1303],{"lat":1303,"lon":1302},[1324],{"name":78,"role":57,"phone":1325,"phoneExt":59,"email":59},"+90 312 552 60 00",{"facility":1327,"status":64,"city":1328,"state":59,"zip":1329,"country":1299,"countryCode":59,"cosmosGeoPoint":1330,"geoPoint":1334,"contacts":1335},"Dr. Siyami Ersek Göğüs Kalp Ve Damar Cerrahisi Eğitim Ve Araştırma Hastanesi ( Site 3302)","Istanbul","34668",{"type":71,"coordinates":1331},[1332,1333],28.94966,41.01384,{"lat":1333,"lon":1332},[1336],{"name":78,"role":57,"phone":1337,"phoneExt":59,"email":59},"+90 216 542 44 44",{"facility":1339,"status":64,"city":1340,"state":59,"zip":1341,"country":1299,"countryCode":59,"cosmosGeoPoint":1342,"geoPoint":1346,"contacts":1347},"S.B.Ü. DR. BEHÇET UZ ÇOCUK HASTALIKLARI VE CERRAHİSİ EĞİTİM VE ARAŞTIRMA HASTANESİ ( Site 3303)","Izmir","35210",{"type":71,"coordinates":1343},[1344,1345],27.13838,38.41273,{"lat":1345,"lon":1344},[1348],{"name":78,"role":57,"phone":1349,"phoneExt":59,"email":59},"+90 232 411 60 00",{"facility":1351,"status":64,"city":1352,"state":1353,"zip":1354,"country":1355,"countryCode":1356,"cosmosGeoPoint":1357,"geoPoint":1361,"contacts":1362},"Great Ormond Street Hospital For Children NHS Foundation Trust ( Site 3401)","London","London, City of","WC1N 3JH","United Kingdom","UK",{"type":71,"coordinates":1358},[1359,1360],-0.12574,51.50853,{"lat":1360,"lon":1359},[1363],{"name":78,"role":57,"phone":1364,"phoneExt":59,"email":59},"020 7405 9200",{"facility":1366,"status":64,"city":1367,"state":59,"zip":1368,"country":1355,"countryCode":1356,"cosmosGeoPoint":1369,"geoPoint":1373,"contacts":1374},"Freeman Hospital ( Site 3400)","Newcastle upon Tyne","NE7 7DN",{"type":71,"coordinates":1370},[1371,1372],-1.61396,54.97328,{"lat":1372,"lon":1371},[1375],{"name":78,"role":57,"phone":1376,"phoneExt":59,"email":59},"07899895040",{"type":1378,"investigatorFullName":59,"investigatorTitle":59,"investigatorAffiliation":59,"oldNameTitle":59,"oldOrganization":59},"SPONSOR","100053407",false,"NCT05714085","Efficacy, Safety, and Pharmacokinetics of Vericiguat in Pediatric Participants With Heart Failure Due to Left Ventricular Systolic Dysfunction (MK-1242-036)","A Phase 2\u002F3 Randomized, Placebo-Controlled, Double-blind, Clinical Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of Vericiguat in Pediatric Participants With Heart Failure Due to Systemic Left Ventricular Systolic Dysfunction (VALOR)","Inclusion Criteria:\n\n* Has symptomatic chronic heart failure (HF) resulting from systemic left ventricular (LV) systolic dysfunction.\n* Has biventricular physiology with a morphologic systemic left ventricle.\n* Is currently receiving stable medical therapy for HF.\n* Has left ventricular ejection fraction (LVEF) \\\u003C45% assessed within 3 months before randomization.\n* Is of any sex\u002Fgender, from \\>28 days to \\\u003C18 years of age inclusive. Must weigh ≥3 kg to participate.\n* Female is eligible to participate if not pregnant or breastfeeding, and at least one of the following: is not a participant of childbearing potential (POCBP); or is a POCBP who uses a highly effective contraceptive method; has a negative highly sensitive pregnancy test; abstains from breastfeeding during the study intervention period and for at least 30 days after study intervention; and their medical history; their menstrual history, and recent sexual activity has been reviewed.\n* Extension Period: Was randomized, received at least 1 dose of study intervention (vericiguat or placebo), did not permanently discontinue study intervention, and completed the Week 52 visit and safety follow-up period of the Base Period\n\nExclusion Criteria:\n\n* Is clinically unstable-with at least one of the following: has symptomatic hypotension or is hypotensive for age, recent use of intravenous (IV) inotrope and\u002For IV vasodilator, or recent IV diuretic.\n* Has a known allergy or sensitivity to vericiguat, any of its constituents, or any other soluble guanylate cyclase (sGC) stimulator.\n* Has a history of single ventricle heart disease or has a morphologic systemic right ventricle.\n* Has undergone heart transplantation, is awaiting heart transplantation United Network for Organ Sharing (UNOS) Class 1A or equivalent, is receiving continuous IV infusion of an inotrope, or has an implanted ventricular assist device.\n* Has sustained or symptomatic dysrhythmia uncontrolled with drug or device therapy.\n* Has had recent cardiovascular (CV) surgical procedure or percutaneous intervention to palliate or correct congenital CV malformations.\n* Has unoperated or residual hemodynamically significant congenital cardiac malformations.\n* Has hypertrophic or restrictive cardiomyopathy.\n* Has active myocarditis or has been recently diagnosed with presumed or definitive myocarditis.\n* Has acute coronary syndrome, undergone recent coronary intervention, or indication for coronary revascularization.\n* Has symptomatic carotid stenosis or other symptomatic cerebrovascular disease\n* Has severe pulmonary hypertension.\n* Requires continuous home oxygen for significant pulmonary disease and\u002For has known interstitial lung disease.\n* Has severe chronic kidney disease.\n* Has hepatic disorder such as hepatic encephalopathy, hepatic laboratory abnormalities or Child Pugh Class C.\n* Has a gastrointestinal or biliary disorder that could impair absorption, metabolism, or excretion of medications.\n* Has significant bone disease (other than osteopenia) that in the assessment of the investigator can alter bone formation\n* Has concurrent or anticipated concomitant use of phosphodiesterase type 5 inhibitors or an sGC stimulator.\n* Has received a COVID-19 vaccination within 1 week before randomization.","ALL","29 Days","17 Years",{"count":1389,"type":1390},342,"ESTIMATED","INTERVENTIONAL",[1393,1394],"PHASE2","PHASE3","This study aims to compare the efficacy of vericiguat versus placebo on change in n-terminal pro-brain natriuretic peptide (NTproBNP) from baseline to Week 16 of the Base Period. The primary hypothesis is that vericiguat is superior to placebo in reducing NT-proBNP at Week 16 of the Base Period.",[1397,1398],"Heart Failure","Left Ventricular Systolic Dysfunction","2026-07-10",{"date":1401,"type":1402},"2026-07-13","ACTUAL",{"date":1404,"type":1402},"2023-05-31",{"date":1406,"type":1390},"2032-04-15",{"name":5,"class":6},107]