The purpose of this study is to evaluate the effect of atorvastatin on brain vessel reactivity and with it on blood flow in people with mild cognitive impairment.
MCI defined by Clinical Dementia Rating (CDR) of 0.5 or 1.0.
Memory, processing speed, executive function, language - cognitive scores > 1.5 standard deviations below age-education norms.
Not demented by history.
Not taking statins currently or in the last 6 months.
Taking a statin currently or have taken a statin in the last 6 months.
Contraindications to taking a statin.
Transplant patient taking cyclosporine.
Unable to undergo MRI procedures (such as having an implanted pacemaker or defibrillator or stimulator or having non MRI compatible metal).
Johns Hopkins University
Lead sponsor
The Richman Family Precision Medicine Center of Excellence in Alzheimer Disease
Collaborator