Sinonasal mucosal malignant melanoma (SNMM) is a nasal and paranasal sinus malignancy with a low incidence and extremely poor prognosis, exhibiting specificity in Asian populations. For resectable SNMM, the efficacy of neoadjuvant immunotherapy is unclear. This prospective clinical study aims to explore the survival prognosis of neoadjuvant immunotherapy combing radiochemotherapy after Endoscopic Surgery for resectable SNMM.
Histopathologically confirmed diagnosis of malignant melanoma of the nasal cavity and paranasal sinuses.
T stage of T3 or T4a.
Age ≥18 years.
No distant metastasis.
Patients who refuse to sign the informed consent form.
Patients with uncontrolled comorbidities that, in the investigator's judgment, would interfere with treatment.
Patients currently suffering from another malignant tumor or with synchronous multiple primary tumors that require treatment.
Patients with surgical contraindications, such as severe cardiopulmonary disease or coagulation disorders.
Eye & ENT Hospital of Fudan University
Lead sponsor
Huadong Hospital
Collaborator