[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100630651":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":25,"centralContacts":30,"locations":36,"responsibleParty":52,"collaborators":56,"id":60,"slug":25,"hasResults":61,"nctId":62,"briefTitle":63,"officialTitle":64,"acronym":25,"eligibilityCriteria":65,"healthyVolunteers":61,"sex":66,"minAge":67,"maxAge":68,"enrollmentInfo":69,"targetDuration":25,"studyType":72,"phases":73,"briefSummary":75,"conditions":76,"keywords":79,"overallStatus":38,"whyStopped":25,"lastUpdateSubmitDate":85,"lastUpdatePostDateStruct":86,"startDateStruct":89,"completionDateStruct":91,"leadSponsor":93,"locationsCount":94},{"fullName":5,"class":6},"Ohio State University","OTHER",[8,15],{"label":9,"type":10,"description":11,"interventionNames":12},"Metric-Optimized First, Clinical Second","EXPERIMENTAL","Participants will be dispensed the metric-optimized spectacle correction for the first two months followed by the clinically determined spectacle correction for the second two months.",[13,14],"Device: Metric-optimized spectacles","Device: Routine Clinical Spectacles",{"label":16,"type":10,"description":17,"interventionNames":18},"Clinical First, Metric-Optimized Second","Participants will be dispensed the clinical spectacle refraction for the first two months followed by the metric-optimized correction for the second two months.",[13,14],[20,26],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"DEVICE","Metric-optimized spectacles","Metric-optimized spectacles are glasses made from a prescription determined by the optimization of a metric for retinal image quality, Visual Strehl Ratio (VSX), as determined by algorithms utilizing wavefront aberration measures of the eye",[16,9],null,{"type":21,"name":27,"description":28,"armGroupLabels":29,"otherNames":25},"Routine Clinical Spectacles","Routine clinical spectacles are glasses made from a prescription based upon findings that are obtained during a routine eye examination, including autorefraction measures.",[16,9],[31],{"name":32,"role":33,"phone":34,"phoneExt":25,"email":35},"Heather Anderson, OD, PhD","CONTACT","614-247-5825","anderson.3881@osu.edu",[37],{"facility":5,"status":38,"city":39,"state":40,"zip":41,"country":42,"countryCode":43,"cosmosGeoPoint":44,"geoPoint":49,"contacts":50},"RECRUITING","Columbus","Ohio","43210","United States","US",{"type":45,"coordinates":46},"Point",[47,48],-82.99879,39.96118,{"lat":48,"lon":47},[51],{"name":32,"role":33,"phone":34,"phoneExt":25,"email":35},{"type":53,"investigatorFullName":54,"investigatorTitle":55,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"PRINCIPAL_INVESTIGATOR","Heather Anderson OD, PhD","Professor",[57],{"name":58,"class":59},"National Eye Institute (NEI)","NIH","100630651",false,"NCT07490444","Metric-Optimized Spectacle Prescriptions for Children With Down Syndrome","Metric-derived Corrections Versus Clinically-derived Corrections for Children With Down Syndrome","Inclusion Criteria:\n\n* Down syndrome\n* Age 5 to 12 years\n* Ability to sit for study measures\n* Able to be dilated\n\nExclusion Criteria:\n\n* Nystagmus\n* History of Ocular or Refractive Surgery\n* Corneal or lenticular opacities\n* Ocular disease\n* Anisometropic or strabismic amblyopia\n* Contact allergy to aluminum","ALL","5 Years","12 Years",{"count":70,"type":71},24,"ESTIMATED","INTERVENTIONAL",[74],"PHASE2","This study seeks to determine whether glasses prescriptions determined from computer analysis of detailed images of the eyes provide better vision outcomes for children with Down syndrome than prescriptions determined using routine clinical methods.",[77,78],"Refractive Error Correction","Visual Acuity",[80,81,82,83,84],"Down syndrome","Children","Glasses","Spectacles","Vision","2026-06-16",{"date":87,"type":88},"2026-06-18","ACTUAL",{"date":90,"type":88},"2026-05-26",{"date":92,"type":71},"2028-05-01",{"name":5,"class":6},1]