Modulating Exercise Dosage to Improve Concussion Recovery

Trial statusRecruiting
Trial phasePhase 2
Trial typeInterventional
Biological sexAll
Age13-18
SponsorUniversity of Colorado, Denver

About this trial

Aerobic exercise has emerged as an effective treatment to reduce sport-related concussion symptom severity, yet existing work lacks rigor regarding the precise exercise volume and intensity required to elicit therapeutic effects, how exercise can alter concussion-related pathophysiology, and whether exercise can prevent the development of secondary sequelae. Our objective is to examine if a high dose exercise program (higher volume than currently prescribed at an individualized, safe intensity level) initiated within 14 days of concussion results in faster symptom resolution, altered physiological function, or reduced secondary sequalae. Findings from this research will lead to more rigorous and precise rehabilitation guidelines and improved understanding about how exercise affects neurophysiological function among adolescents with concussion.

Eligibility criteria

Qualifiers

13-18 years of age

Post-Concussion Symptom Scale (PCSS) score >10 to ensure participants are not recovered by enrollment

Concussion diagnosis by a sports medicine physician

Disqualifiers

Pre-existing neurological disorders

Exercise contraindications

Concussion <6 months before enrollment (excluding the current injury)

Trial design

Treatments tested in this trial

  • High Dose Exercise

Treatment groups

216 Participants
are divided into 2 treatment groups

Sponsors and collaborators

University of Colorado, Denver

Lead sponsor

Boston Children's Hospital

Collaborator

Spaulding Rehabilitation Hospital

Collaborator

Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)

Collaborator