About this trial
Aerobic exercise has emerged as an effective treatment to reduce sport-related concussion symptom severity, yet existing work lacks rigor regarding the precise exercise volume and intensity required to elicit therapeutic effects, how exercise can alter concussion-related pathophysiology, and whether exercise can prevent the development of secondary sequelae. Our objective is to examine if a high dose exercise program (higher volume than currently prescribed at an individualized, safe intensity level) initiated within 14 days of concussion results in faster symptom resolution, altered physiological function, or reduced secondary sequalae. Findings from this research will lead to more rigorous and precise rehabilitation guidelines and improved understanding about how exercise affects neurophysiological function among adolescents with concussion.
Eligibility criteria
Qualifiers
13-18 years of age
Post-Concussion Symptom Scale (PCSS) score >10 to ensure participants are not recovered by enrollment
Concussion diagnosis by a sports medicine physician
Disqualifiers
Pre-existing neurological disorders
Exercise contraindications
Concussion <6 months before enrollment (excluding the current injury)
Trial design
Treatments tested in this trial
- High Dose Exercise
Treatment groups
Sponsors and collaborators
University of Colorado, Denver
Lead sponsor
Boston Children's Hospital
Collaborator
Spaulding Rehabilitation Hospital
Collaborator
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Collaborator