Perioperative Vitamin C to Reduce Persistent Pain After Total Knee Arthroplasty
Trial statusRecruiting
Trial phasePhase 2
Trial typeInterventional
Biological sexAll
Age18+
SponsorUniversity Health Network, Toronto
About this trial
Phase II Multicentre, pilot, parallel-group, blinded, 1:1 randomized controlled trial to determine the feasibility of conducting a larger definitive trail of using vitamin C to reduce persistent pain in patients undergoing total knee arthroplasty surgery.
Eligibility criteria
Qualifiers
Patients >18 years old
Undergoing a unilateral or bilateral primary total knee arthroplasty for advanced osteoarthritis of the knee
Disqualifiers
TKA for infection (septic joint), fracture, ankylosing spondylitis, lupus, or psoriatic arthritis
History of kidney stones, acute or chronic renal failure, hemochromatosis, or glucose-6-phosphate deficiency
Unlikely to comply with follow-up (e.g., no fixed address, plans to move out of town)
Language difficulties that would impede valid completion of questionnaires
Trial design
Treatments tested in this trial
- Vitamin C
- Placebo
Treatment groups
400 Participants
are divided into 2 treatment groupsSponsors and collaborators
University Health Network, Toronto
Lead sponsor
Canadian Institutes of Health Research (CIHR)
Collaborator
The Arthritis Society, Canada
Collaborator
Source ClinicalTrials.gov