Randomized Study of ABC-14 Regimen Compared With "3+7" Standard Induction Therapy or AB-14 for ND AML

Trial statusRecruiting
Trial phasePhase 2
Trial typeInterventional
Biological sexAll
Age18+
SponsorGuangdong Provincial People's Hospital

About this trial

To compare the efficacy and safty of ABC-14 regimen with the traditional "3+7" regimen or AB-14 regimen in the treatment of newly diagnosed acute myeloid leukaemia

Eligibility criteria

Qualifiers

Diagnosed with AML (the diagnostic criteria refer to WHO2022 standard, non-APL), and have not received systemic anti-leukemia therapy (except hydroxyurea, low-dose cytarabine and other tumor reduction pretreatments);

Age ≥18 years old;

ECOG≤4;

The fertile woman agrees to use effective contraception during the treatment period and up to 3 months after the end of the treatment; Sign the informed consent form.

Disqualifiers

Known history of allergy to the investigational drug;

Resistance to azacytidine, azacitidine, Venetoclax;

Inability to take oral medication;

Combined with uncontrolled active infections (including bacterial, fungal or viral infections);

Trial design

Treatments tested in this trial

  • Chidamide
  • Venetoclax
  • azacitidine
  • Anthracyclines or anthraquinones
  • cytarabine

Treatment groups

240 Participants
are divided into 3 treatment groups