[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100610393":3},{"organization":4,"armGroups":7,"interventions":24,"overallOfficials":39,"centralContacts":43,"locations":48,"responsibleParty":428,"collaborators":30,"id":430,"slug":30,"hasResults":431,"nctId":432,"briefTitle":433,"officialTitle":434,"acronym":30,"eligibilityCriteria":435,"healthyVolunteers":431,"sex":436,"minAge":437,"maxAge":30,"enrollmentInfo":438,"targetDuration":30,"studyType":441,"phases":442,"briefSummary":445,"conditions":446,"keywords":448,"overallStatus":51,"whyStopped":30,"lastUpdateSubmitDate":452,"lastUpdatePostDateStruct":453,"startDateStruct":456,"completionDateStruct":458,"leadSponsor":460,"locationsCount":461},{"fullName":5,"class":6},"Pfizer","INDUSTRY",[8,15,18],{"label":9,"type":10,"description":11,"interventionNames":12},"Phase 2 Single arm","EXPERIMENTAL","Participants will receive PF-08634404 in combination with chemotherapy",[13,14],"Drug: PF-08634404","Drug: Chemotherapy",{"label":16,"type":10,"description":11,"interventionNames":17},"Phase 3 Experimental Arm",[13,14],{"label":19,"type":20,"description":21,"interventionNames":22},"Phase3 Control Arm","ACTIVE_COMPARATOR","Participants will receive atezolizumab in combination with chemotherapy",[23,14],"Biological: Atezolizumab",[25,31,36],{"type":26,"name":27,"description":28,"armGroupLabels":29,"otherNames":30},"DRUG","PF-08634404","Concentrate for solution for infusion",[9,16],null,{"type":32,"name":33,"description":34,"armGroupLabels":35,"otherNames":30},"BIOLOGICAL","Atezolizumab","Injection for intravenous use",[19],{"type":26,"name":37,"description":34,"armGroupLabels":38,"otherNames":30},"Chemotherapy",[9,16,19],[40],{"name":41,"affiliation":5,"role":42},"Pfizer CT.gov Call Center","STUDY_DIRECTOR",[44],{"name":41,"role":45,"phone":46,"phoneExt":30,"email":47},"CONTACT","1-800-718-1021","ClinicalTrials.gov_Inquiries@pfizer.com",[49,63,71,79,89,98,107,117,126,134,139,147,155,163,168,173,181,189,197,207,215,223,231,239,251,261,274,284,295,305,317,329,334,345,354,363,369,381,390,396,402,413,422],{"facility":50,"status":51,"city":52,"state":53,"zip":54,"country":55,"countryCode":56,"cosmosGeoPoint":57,"geoPoint":62,"contacts":30},"Highlands Oncology Group","RECRUITING","Fayetteville","Arkansas","72703","United States","US",{"type":58,"coordinates":59},"Point",[60,61],-94.15743,36.06258,{"lat":61,"lon":60},{"facility":50,"status":51,"city":64,"state":53,"zip":65,"country":55,"countryCode":56,"cosmosGeoPoint":66,"geoPoint":70,"contacts":30},"Rogers","72758",{"type":58,"coordinates":67},[68,69],-94.11854,36.33202,{"lat":69,"lon":68},{"facility":50,"status":51,"city":72,"state":53,"zip":73,"country":55,"countryCode":56,"cosmosGeoPoint":74,"geoPoint":78,"contacts":30},"Springdale","72762",{"type":58,"coordinates":75},[76,77],-94.12881,36.18674,{"lat":77,"lon":76},{"facility":80,"status":51,"city":81,"state":82,"zip":83,"country":55,"countryCode":56,"cosmosGeoPoint":84,"geoPoint":88,"contacts":30},"BRCR Coral Springs","Coral Springs","Florida","33065",{"type":58,"coordinates":85},[86,87],-80.2706,26.27119,{"lat":87,"lon":86},{"facility":90,"status":51,"city":91,"state":82,"zip":92,"country":55,"countryCode":56,"cosmosGeoPoint":93,"geoPoint":97,"contacts":30},"Mid Florida Hematology and Oncology Center","Orange City","32763",{"type":58,"coordinates":94},[95,96],-81.29867,28.94888,{"lat":96,"lon":95},{"facility":99,"status":51,"city":100,"state":82,"zip":101,"country":55,"countryCode":56,"cosmosGeoPoint":102,"geoPoint":106,"contacts":30},"BRCR Global - Tamarac","Tamarac","33321",{"type":58,"coordinates":103},[104,105],-80.24977,26.21286,{"lat":105,"lon":104},{"facility":108,"status":51,"city":109,"state":110,"zip":111,"country":55,"countryCode":56,"cosmosGeoPoint":112,"geoPoint":116,"contacts":30},"Texas Oncology - Gulf Coast","Beaumont","Texas","77702",{"type":58,"coordinates":113},[114,115],-94.10185,30.08605,{"lat":115,"lon":114},{"facility":118,"status":51,"city":119,"state":110,"zip":120,"country":55,"countryCode":56,"cosmosGeoPoint":121,"geoPoint":125,"contacts":30},"Texas Oncology - San Antonio","Fredericksburg","78624",{"type":58,"coordinates":122},[123,124],-98.87198,30.2752,{"lat":124,"lon":123},{"facility":108,"status":51,"city":127,"state":110,"zip":128,"country":55,"countryCode":56,"cosmosGeoPoint":129,"geoPoint":133,"contacts":30},"Houston","77024",{"type":58,"coordinates":130},[131,132],-95.36327,29.76328,{"lat":132,"lon":131},{"facility":108,"status":51,"city":127,"state":110,"zip":135,"country":55,"countryCode":56,"cosmosGeoPoint":136,"geoPoint":138,"contacts":30},"77054",{"type":58,"coordinates":137},[131,132],{"lat":132,"lon":131},{"facility":118,"status":51,"city":140,"state":110,"zip":141,"country":55,"countryCode":56,"cosmosGeoPoint":142,"geoPoint":146,"contacts":30},"New Braunfels","78130",{"type":58,"coordinates":143},[144,145],-98.12445,29.703,{"lat":145,"lon":144},{"facility":108,"status":51,"city":148,"state":110,"zip":149,"country":55,"countryCode":56,"cosmosGeoPoint":150,"geoPoint":154,"contacts":30},"Pearland","77584",{"type":58,"coordinates":151},[152,153],-95.28605,29.56357,{"lat":153,"lon":152},{"facility":118,"status":51,"city":156,"state":110,"zip":157,"country":55,"countryCode":56,"cosmosGeoPoint":158,"geoPoint":162,"contacts":30},"San Antonio","78217",{"type":58,"coordinates":159},[160,161],-98.49363,29.42412,{"lat":161,"lon":160},{"facility":118,"status":51,"city":156,"state":110,"zip":164,"country":55,"countryCode":56,"cosmosGeoPoint":165,"geoPoint":167,"contacts":30},"78240",{"type":58,"coordinates":166},[160,161],{"lat":161,"lon":160},{"facility":118,"status":51,"city":156,"state":110,"zip":169,"country":55,"countryCode":56,"cosmosGeoPoint":170,"geoPoint":172,"contacts":30},"78258",{"type":58,"coordinates":171},[160,161],{"lat":161,"lon":160},{"facility":108,"status":51,"city":174,"state":110,"zip":175,"country":55,"countryCode":56,"cosmosGeoPoint":176,"geoPoint":180,"contacts":30},"Sugar Land","77479",{"type":58,"coordinates":177},[178,179],-95.63495,29.61968,{"lat":179,"lon":178},{"facility":108,"status":51,"city":182,"state":110,"zip":183,"country":55,"countryCode":56,"cosmosGeoPoint":184,"geoPoint":188,"contacts":30},"The Woodlands","77380",{"type":58,"coordinates":185},[186,187],-95.48938,30.15799,{"lat":187,"lon":186},{"facility":108,"status":51,"city":190,"state":110,"zip":191,"country":55,"countryCode":56,"cosmosGeoPoint":192,"geoPoint":196,"contacts":30},"Webster","77598",{"type":58,"coordinates":193},[194,195],-95.11826,29.53773,{"lat":195,"lon":194},{"facility":198,"status":51,"city":199,"state":200,"zip":201,"country":55,"countryCode":56,"cosmosGeoPoint":202,"geoPoint":206,"contacts":30},"Oncology & Hematology Associates of Southwest Virginia, Inc., DBA Blue Ridge Cancer Care","Blacksburg","Virginia","24060",{"type":58,"coordinates":203},[204,205],-80.41394,37.22957,{"lat":205,"lon":204},{"facility":198,"status":51,"city":208,"state":200,"zip":209,"country":55,"countryCode":56,"cosmosGeoPoint":210,"geoPoint":214,"contacts":30},"Low Moor","24457",{"type":58,"coordinates":211},[212,213],-79.88366,37.78874,{"lat":213,"lon":212},{"facility":198,"status":51,"city":216,"state":200,"zip":217,"country":55,"countryCode":56,"cosmosGeoPoint":218,"geoPoint":222,"contacts":30},"Roanoke","24014",{"type":58,"coordinates":219},[220,221],-79.94143,37.27097,{"lat":221,"lon":220},{"facility":198,"status":51,"city":224,"state":200,"zip":225,"country":55,"countryCode":56,"cosmosGeoPoint":226,"geoPoint":230,"contacts":30},"Salem","24153",{"type":58,"coordinates":227},[228,229],-80.05476,37.29347,{"lat":229,"lon":228},{"facility":198,"status":51,"city":232,"state":200,"zip":233,"country":55,"countryCode":56,"cosmosGeoPoint":234,"geoPoint":238,"contacts":30},"Wytheville","24382",{"type":58,"coordinates":235},[236,237],-81.08481,36.94845,{"lat":237,"lon":236},{"facility":240,"status":51,"city":241,"state":242,"zip":243,"country":244,"countryCode":245,"cosmosGeoPoint":246,"geoPoint":250,"contacts":30},"Westmead Hospital","Westmead","New South Wales","2145","Australia","AU",{"type":58,"coordinates":247},[248,249],150.98768,-33.80383,{"lat":249,"lon":248},{"facility":252,"status":51,"city":253,"state":254,"zip":255,"country":244,"countryCode":245,"cosmosGeoPoint":256,"geoPoint":260,"contacts":30},"Sunshine Coast University Hospital","Birtinya","Queensland","4575",{"type":58,"coordinates":257},[258,259],153.11913,-26.74322,{"lat":259,"lon":258},{"facility":262,"status":263,"city":264,"state":265,"zip":266,"country":267,"countryCode":268,"cosmosGeoPoint":269,"geoPoint":273,"contacts":30},"Guangdong Provincial People's Hospital","NOT_YET_RECRUITING","Guangzhou","Guangdong","510180","China","CN",{"type":58,"coordinates":270},[271,272],113.25,23.11667,{"lat":272,"lon":271},{"facility":275,"status":263,"city":276,"state":277,"zip":278,"country":267,"countryCode":268,"cosmosGeoPoint":279,"geoPoint":283,"contacts":30},"Fudan University Shanghai Cancer Center","Shanghai","Shanghai Municipality","200032",{"type":58,"coordinates":280},[281,282],121.45806,31.22222,{"lat":282,"lon":281},{"facility":285,"status":263,"city":286,"state":30,"zip":287,"country":288,"countryCode":289,"cosmosGeoPoint":290,"geoPoint":294,"contacts":30},"Gustave Roussy","Villejuif","94805","France","FR",{"type":58,"coordinates":291},[292,293],2.35992,48.7939,{"lat":293,"lon":292},{"facility":296,"status":263,"city":297,"state":298,"zip":299,"country":288,"countryCode":289,"cosmosGeoPoint":300,"geoPoint":304,"contacts":30},"Hôpital Ambroise Paré","Boulogne-Billancourt","Île-de-France Region","92100",{"type":58,"coordinates":301},[302,303],2.24128,48.83545,{"lat":303,"lon":302},{"facility":306,"status":263,"city":307,"state":308,"zip":309,"country":310,"countryCode":311,"cosmosGeoPoint":312,"geoPoint":316,"contacts":30},"IRCCS Istituto Nazionale dei Tumori Regina Elena","Roma","ROME","00144","Italy","IT",{"type":58,"coordinates":313},[314,315],11.10642,44.99364,{"lat":315,"lon":314},{"facility":318,"status":51,"city":319,"state":320,"zip":321,"country":322,"countryCode":323,"cosmosGeoPoint":324,"geoPoint":328,"contacts":30},"Kansai Medical University Hospital","Hirakata","Osaka","573-1191","Japan","JP",{"type":58,"coordinates":325},[326,327],135.64914,34.81352,{"lat":327,"lon":326},{"facility":330,"status":51,"city":331,"state":332,"zip":333,"country":322,"countryCode":323,"cosmosGeoPoint":30,"geoPoint":30,"contacts":30},"Shizuoka Cancer Center","Nagaizumi-cho","Shizuoka","411-8777",{"facility":335,"status":51,"city":336,"state":30,"zip":337,"country":338,"countryCode":339,"cosmosGeoPoint":340,"geoPoint":344,"contacts":30},"Doctor's Center Hematology & Oncology Group","Manati","00674","Puerto Rico","PR",{"type":58,"coordinates":341},[342,343],-66.49212,18.42745,{"lat":343,"lon":342},{"facility":346,"status":51,"city":347,"state":30,"zip":348,"country":338,"countryCode":339,"cosmosGeoPoint":349,"geoPoint":353,"contacts":30},"Pan American Center for Oncology Trials, LLC - Mayaguez Office Mayaguez Medical Center","Mayagüez","00680",{"type":58,"coordinates":350},[351,352],-67.13962,18.20107,{"lat":352,"lon":351},{"facility":355,"status":51,"city":356,"state":30,"zip":357,"country":338,"countryCode":339,"cosmosGeoPoint":358,"geoPoint":362,"contacts":30},"Pan American Center for Oncology Trials, LLC","San Juan","00909",{"type":58,"coordinates":359},[360,361],-66.10572,18.46633,{"lat":361,"lon":360},{"facility":364,"status":51,"city":356,"state":30,"zip":365,"country":338,"countryCode":339,"cosmosGeoPoint":366,"geoPoint":368,"contacts":30},"Hospital Oncologico Dr. Isaac Gonzalez-Martinez","00935",{"type":58,"coordinates":367},[360,361],{"lat":361,"lon":360},{"facility":370,"status":263,"city":371,"state":372,"zip":373,"country":374,"countryCode":375,"cosmosGeoPoint":376,"geoPoint":380,"contacts":30},"Hospital Universitario 12 de Octubre","Madrid","Madrid, Comunidad de","28041","Spain","ES",{"type":58,"coordinates":377},[378,379],-3.70256,40.4165,{"lat":379,"lon":378},{"facility":382,"status":263,"city":383,"state":30,"zip":384,"country":374,"countryCode":375,"cosmosGeoPoint":385,"geoPoint":389,"contacts":30},"Parc de Salut Mar - Hospital del Mar","Barcelona","08003",{"type":58,"coordinates":386},[387,388],2.15899,41.38879,{"lat":388,"lon":387},{"facility":391,"status":51,"city":383,"state":30,"zip":392,"country":374,"countryCode":375,"cosmosGeoPoint":393,"geoPoint":395,"contacts":30},"CETIR","08029",{"type":58,"coordinates":394},[387,388],{"lat":388,"lon":387},{"facility":397,"status":51,"city":383,"state":30,"zip":398,"country":374,"countryCode":375,"cosmosGeoPoint":399,"geoPoint":401,"contacts":30},"Hospital Universitari Vall d'Hebron","08035",{"type":58,"coordinates":400},[387,388],{"lat":388,"lon":387},{"facility":403,"status":51,"city":404,"state":30,"zip":405,"country":406,"countryCode":407,"cosmosGeoPoint":408,"geoPoint":412,"contacts":30},"National Cheng Kung University Hospital","Tainan","704302","Taiwan","TW",{"type":58,"coordinates":409},[410,411],120.21333,22.99083,{"lat":411,"lon":410},{"facility":414,"status":51,"city":415,"state":30,"zip":416,"country":406,"countryCode":407,"cosmosGeoPoint":417,"geoPoint":421,"contacts":30},"National Taiwan University Hospital","Taipei","10002",{"type":58,"coordinates":418},[419,420],121.52639,25.05306,{"lat":420,"lon":419},{"facility":423,"status":51,"city":415,"state":30,"zip":424,"country":406,"countryCode":407,"cosmosGeoPoint":425,"geoPoint":427,"contacts":30},"Taipei Medical University Hospital","110",{"type":58,"coordinates":426},[419,420],{"lat":420,"lon":419},{"type":429,"investigatorFullName":30,"investigatorTitle":30,"investigatorAffiliation":30,"oldNameTitle":30,"oldOrganization":30},"SPONSOR","100610393",false,"NCT07226999","Symbiotic-Lung-04: A Study to Learn About the Study Medicine Called PF-08634404 in Combination With Chemotherapy in Adult Participants With Extensive-Stage Small Cell Lung Cancer","A GLOBAL PHASE 2\u002F3 INTERVENTIONAL STUDY OF PF-08634404 IN COMBINATION WITH CHEMOTHERAPY IN PARTICIPANTS WITH EXTENSIVE STAGE SMALL CELL LUNG CANCER","Inclusion Criteria:\n\n* Histologically or cytologically confirmed extensive-stage small cell lung cancer (ES-SCLC).\n* Participants have not received systemic therapy (chemotherapy, radiotherapy, chemoradiation) for ES-SCLC.\n* Treatment-free for at least 6 months since last chemo\u002Fradiotherapy, among those treated (with curative intent) with prior chemo\u002Fradiotherapy for limited-stage SCLC\n* Have at least one measurable lesion as the targeted lesion based on RECIST V1.1.\n* Eastern Cooperative Oncology Group performance status of 0 or 1.\n* Adequate organ function\n\nExclusion Criteria:\n\n* known active CNS lesions, including brainstem, meningeal, or spinal cord metastases or compression\n* Leptomeningeal disease\n* Clinically significant risk of hemorrhage or fistula\n* history of another malignancy within 3 years\n* active autoimmune diseases requiring systemic treatment within the past 2 years","ALL","18 Years",{"count":439,"type":440},550,"ESTIMATED","INTERVENTIONAL",[443,444],"PHASE2","PHASE3","This study is being done to learn more about a new medicine called PF-08634404 and how well it works when given with chemotherapy to adults with extensive-stage small cell lung cancer (ES-SCLC), a fast-growing type of lung cancer that has spread widely in the body.\n\nTo join the study, participants must meet the following conditions:\n\n* Be 18 years or older.\n* Have extensive-stage small cell lung cancer confirmed by lab tests.\n* Have not received chemotherapy or radiation for this type of lung cancer.\n* Be in good physical condition and have healthy organs based on medical tests.\n\nThe study has two parts:\n\n* In the first part, researchers will check how safe the study medicine is and how well people tolerate it when given with chemotherapy.\n* In the second part, they will compare study medicine plus chemotherapy to another approved treatment (atezolizumab plus chemotherapy) to see which works better.\n\nParticipants will receive the treatment through IV infusions (medicine given directly into a vein). The treatment will be given in repeated time periods called cycles. Some participants will continue receiving the study medicine alone after the initial treatment.",[447],"Small Cell Lung Cancer (SCLC)",[449,450,451],"small cell lung cancer","extensive stage small cell lung cancer","first-line","2026-06-03",{"date":454,"type":455},"2026-06-04","ACTUAL",{"date":457,"type":455},"2025-12-09",{"date":459,"type":440},"2034-03-11",{"name":5,"class":6},43]