[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100477648":3},{"organization":4,"armGroups":7,"interventions":15,"overallOfficials":27,"centralContacts":31,"locations":37,"responsibleParty":52,"collaborators":21,"id":55,"slug":21,"hasResults":56,"nctId":57,"briefTitle":58,"officialTitle":58,"acronym":21,"eligibilityCriteria":59,"healthyVolunteers":56,"sex":60,"minAge":61,"maxAge":62,"enrollmentInfo":63,"targetDuration":21,"studyType":66,"phases":67,"briefSummary":69,"conditions":70,"keywords":72,"overallStatus":40,"whyStopped":21,"lastUpdateSubmitDate":78,"lastUpdatePostDateStruct":79,"startDateStruct":82,"completionDateStruct":84,"leadSponsor":86,"locationsCount":87},{"fullName":5,"class":6},"Mayo Clinic","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Adults with type 2 diabetes","EXPERIMENTAL","20 subjects will be studied on one occasion, following 6 weeks of caloric restriction. They will be instructed to consume a diet of 900 kcal daily using meals derived from \"Nutritional Guidelines after Bariatric Surgery\". Compliance will be monitored by weekly meetings with the dietician using an electronic record of food intake. After this subjects will undergo a hyperglycemic clamp with 2 doses of glucagon infused.",[13,14],"Behavioral: Caloric Restriction","Drug: Hyperglycemic clamp",[16,22],{"type":17,"name":18,"description":19,"armGroupLabels":20,"otherNames":21},"BEHAVIORAL","Caloric Restriction","Subjects will be instructed to consume a diet of 900 kcal daily using meals derived from \"Nutritional Guidelines after Bariatric Surgery\". Compliance will be monitored by weekly meetings with the dietician using an electronic record of food intake",[9],null,{"type":23,"name":24,"description":25,"armGroupLabels":26,"otherNames":21},"DRUG","Hyperglycemic clamp","Hyperglycemic clamp to measure the effect of glucagon on hepatic metabolism",[9],[28],{"name":29,"affiliation":5,"role":30},"Adrian Vella","PRINCIPAL_INVESTIGATOR",[32],{"name":33,"role":34,"phone":35,"phoneExt":21,"email":36},"Jeanette Laugen","CONTACT","5072558110","Laugen.Jeanette@mayo.edu",[38],{"facility":39,"status":40,"city":41,"state":42,"zip":43,"country":44,"countryCode":45,"cosmosGeoPoint":46,"geoPoint":51,"contacts":21},"Mayo Clinic in Rochester","RECRUITING","Rochester","Minnesota","55905","United States","US",{"type":47,"coordinates":48},"Point",[49,50],-92.4699,44.02163,{"lat":50,"lon":49},{"type":53,"investigatorFullName":29,"investigatorTitle":54,"investigatorAffiliation":5,"oldNameTitle":21,"oldOrganization":21},"SPONSOR_INVESTIGATOR","Principal Investigator","100477648",false,"NCT05499702","The Effects of Glucagon on Hepatic Metabolism in People With Type 2 Diabetes After Caloric Restriction","Inclusion Criteria:\n\n* We will recruit up to 20 weight-stable, subjects with type 2 diabetes\n* BMI ≥ 28 Kg\u002FM2\n* Diabetes is managed by diet alone or a combination of oral agents\n\nExclusion Criteria:\n\n* History of prior upper abdominal surgery e.g. gastric banding, pyloroplasty, vagotomy.\n* Active systemic illness or malignancy.\n* Symptomatic macrovascular or microvascular disease.\n* Contraindications to MRI (e.g. metal implants, claustrophobia).\n* Hematocrit \\\u003C 35%\n* TSH \\\u003C 0.4 or \\> 5.5.\n* Consumption of \\> 2 alcohol drinks per day or \\> 14 per week or a positive AUDIT questionnaire.","ALL","25 Years","65 Years",{"count":64,"type":65},20,"ESTIMATED","INTERVENTIONAL",[68],"PHASE2","Caloric restriction (and RYGB) improves insulin action and lowers fasting glucose, glucagon and EGP, without changes in postprandial EGP and glucagon concentrations. Caloric restriction also improves hepatic steatosis and lowers fasting AA. These changes may represent restoration of glucagon's hepatic actions. This experiment will determine whether caloric restriction improves glucagon's actions on hepatic amino acid, carbohydrate and lipid metabolism in T2DM in comparison to a baseline experiment performed separately in people with T2DM.",[71],"Type2diabetes",[73,74,75,76,77],"glucagon","insulin resistance","caloric restriction","hepatic steatosis","amino acid metabolism","2026-05-26",{"date":80,"type":81},"2026-05-28","ACTUAL",{"date":83,"type":81},"2022-12-15",{"date":85,"type":65},"2027-12-31",{"name":29,"class":6},1]