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Chebotarova NAMS of Ukraine_Site n. 804001","04114",{"type":59,"coordinates":1663},[1644,1645],{"lat":1645,"lon":1644},[1666],{"name":1667,"role":43,"phone":31,"phoneExt":31,"email":31},"Ervin Asanov",{"facility":1669,"status":53,"city":1640,"state":31,"zip":1670,"country":1586,"countryCode":1587,"cosmosGeoPoint":1671,"geoPoint":1673,"contacts":1674},"Kyiv Railway Clinical Hospital No. 2 of Branch \"Healthcare Center\" of the PJSC \"Ukrainian Railway\"_Site n.804013","3049",{"type":59,"coordinates":1672},[1644,1645],{"lat":1645,"lon":1644},[1675],{"name":1676,"role":43,"phone":31,"phoneExt":31,"email":31},"Bogdan Gundertaylo",{"facility":1678,"status":53,"city":1640,"state":31,"zip":1679,"country":1586,"countryCode":1587,"cosmosGeoPoint":1680,"geoPoint":1682,"contacts":1683},"National Scientific Center of Phthisiatry Pulmonology and Allergology after F.G. Yanovsky_Site n. 804016","3680",{"type":59,"coordinates":1681},[1644,1645],{"lat":1645,"lon":1644},[1684],{"name":1685,"role":43,"phone":31,"phoneExt":31,"email":31},"Volodymyr Gavrysyuk",{"facility":1687,"status":53,"city":1688,"state":31,"zip":1689,"country":1586,"countryCode":1587,"cosmosGeoPoint":1690,"geoPoint":1694,"contacts":1695},"Odesa Regional Clinical Hospital of Odesa Regional Council_Site n. 804008","Odesa","65025",{"type":59,"coordinates":1691},[1692,1693],30.74383,46.48572,{"lat":1693,"lon":1692},[1696],{"name":1697,"role":43,"phone":31,"phoneExt":31,"email":31},"Yuliia Novosolova",{"facility":1699,"status":53,"city":1700,"state":31,"zip":1701,"country":1586,"countryCode":1587,"cosmosGeoPoint":1702,"geoPoint":1706,"contacts":1707},"Limited Liability Company Medical and Diagnostic Center \"Medion\"_Site n. 804007","Poltava","36039",{"type":59,"coordinates":1703},[1704,1705],34.55367,49.58925,{"lat":1705,"lon":1704},[1708],{"name":1709,"role":43,"phone":31,"phoneExt":31,"email":31},"Ivan Kryvoruchko",{"facility":1711,"status":53,"city":1712,"state":31,"zip":1713,"country":1586,"countryCode":1587,"cosmosGeoPoint":1714,"geoPoint":1718,"contacts":1719},"University Clinic of Vinnytsia National Medical University named after M.I. 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Southmead Hospital Bristol_Site n. 826010","Bristol","BS10 5NB",{"type":59,"coordinates":1757},[1758,1759],-2.59665,51.45523,{"lat":1759,"lon":1758},[1762],{"name":1763,"role":43,"phone":31,"phoneExt":31,"email":31},"James Dodd",{"facility":1765,"status":53,"city":1754,"state":31,"zip":1766,"country":1742,"countryCode":1743,"cosmosGeoPoint":1767,"geoPoint":1769,"contacts":1770},"Concord Medical Centre_Site n. 826009","BS34 6BQ",{"type":59,"coordinates":1768},[1758,1759],{"lat":1759,"lon":1758},[1771],{"name":1772,"role":43,"phone":31,"phoneExt":31,"email":31},"James Case",{"facility":1774,"status":53,"city":1775,"state":31,"zip":1776,"country":1742,"countryCode":1743,"cosmosGeoPoint":1777,"geoPoint":1781,"contacts":1782},"Elpida Trials - Parloes Hub_Site n. 826003","Dagenham","RM9 5QP",{"type":59,"coordinates":1778},[1779,1780],0.16667,51.55,{"lat":1780,"lon":1779},[1783],{"name":1784,"role":43,"phone":31,"phoneExt":31,"email":31},"Ravali Goriparthi",{"facility":1786,"status":53,"city":1787,"state":31,"zip":1788,"country":1742,"countryCode":1743,"cosmosGeoPoint":1789,"geoPoint":1793,"contacts":1794},"4 Medical Clinical Solutions (4MCS) - London_Site n. 826004","London","IG1 4HP",{"type":59,"coordinates":1790},[1791,1792],-0.12574,51.50853,{"lat":1792,"lon":1791},[1795],{"name":1796,"role":43,"phone":31,"phoneExt":31,"email":31},"Martin Palin",{"facility":1798,"status":53,"city":1799,"state":31,"zip":1800,"country":1742,"countryCode":1743,"cosmosGeoPoint":1801,"geoPoint":1805,"contacts":1806},"Maidstone and Tunbridge Wells NHS Trust - Maidstone Hospital_Site n. 826008","Maidstone","ME16 9QQ",{"type":59,"coordinates":1802},[1803,1804],0.51667,51.26667,{"lat":1804,"lon":1803},[1807],{"name":1808,"role":43,"phone":31,"phoneExt":31,"email":31},"Tuck-Kay Loke",{"facility":1810,"status":53,"city":1811,"state":31,"zip":1812,"country":1742,"countryCode":1743,"cosmosGeoPoint":1813,"geoPoint":1817,"contacts":1818},"Medicines Evaluation Unit_Site n. 826006","Manchester","M23 9QZ",{"type":59,"coordinates":1814},[1815,1816],-2.23743,53.48095,{"lat":1816,"lon":1815},[1819],{"name":1820,"role":43,"phone":31,"phoneExt":31,"email":31},"Dave Singh",{"facility":1822,"status":53,"city":1823,"state":31,"zip":1824,"country":1742,"countryCode":1743,"cosmosGeoPoint":1825,"geoPoint":1829,"contacts":1830},"Accellacare South London_Site n. 826001","Orpington","BR5 3QG",{"type":59,"coordinates":1826},[1827,1828],0.09785,51.37457,{"lat":1828,"lon":1827},[1831],{"name":1832,"role":43,"phone":31,"phoneExt":31,"email":31},"Njobuenwnu Hyacienth Amah",{"facility":1834,"status":53,"city":1835,"state":31,"zip":1836,"country":1742,"countryCode":1743,"cosmosGeoPoint":1837,"geoPoint":1841,"contacts":1842},"Portsmouth Hospitals NHS Trust - Queen Alexandra Hospital_Site n. 826002","Portsmouth","PO6 3LY",{"type":59,"coordinates":1838},[1839,1840],-1.09125,50.79899,{"lat":1840,"lon":1839},[1843],{"name":1844,"role":43,"phone":31,"phoneExt":31,"email":31},"Thomas Brown",{"facility":1846,"status":53,"city":1847,"state":31,"zip":1848,"country":1742,"countryCode":1743,"cosmosGeoPoint":1849,"geoPoint":1853,"contacts":1854},"Abbeywell Surgery_Site n. 826007","Romsey","SO51 8EN",{"type":59,"coordinates":1850},[1851,1852],-1.49989,50.98906,{"lat":1852,"lon":1851},[1855],{"name":1856,"role":43,"phone":31,"phoneExt":31,"email":31},"Nicola Lester",{"type":1858,"investigatorFullName":31,"investigatorTitle":31,"investigatorAffiliation":31,"oldNameTitle":31,"oldOrganization":31},"SPONSOR","100616140",false,"NCT07301736","Therapeutic Equivalence of CHF5993 pMDI 100\u002F6\u002F12.5 µg HFA-152a in Subjects With Mild to Moderate Asthma","A Phase II Multinational, Multicentre, Double-blind, Randomised, Active-controlled, 3-way Cross-over Study to Evaluate the Therapeutic Equivalence of CHF5993 pMDI 100\u002F6\u002F12.5 µg HFA-152a Versus CHF5993 pMDI 100\u002F6\u002F12.5 µg HFA-134a in Subjects With Mild to Moderate Asthma","TRECONY","Inclusion Criteria:\n\n* Male and female adults (18 ≤ age ≤ 75 years) with a diagnosis of Asthma for at least 6 months prior to screening and with diagnosis before the age of 50 years;\n* Non-smokers, ex-smokers;\n* Body mass index: within the range of 18.0 to 35.0 kg\u002Fm2 inclusive;\n* Stable asthma therapy: a stable maintenance treatment for at least 4 weeks prior to screening with:\n\n  1. low or medium doses of ICS (Inhaled Corticosteroids) alone; or\n  2. low or medium doses of ICS + LABA (Long-acting β2-agonist) (fixed or free combination).\n* Controlled or partly controlled based on an Asthma Control Questionnaire - 7 Items (ACQ-7) score \\\u003C1.5 at screening and at randomisation.\n* Pre-BD (Bronchodilator) FEV1 \\>40% and \\\u003C90% of the predicted normal value, after appropriate wash out from BDs, at the Screening Visit (V1).\n* A demonstrated increase in either FEV1 or forced vital capacity of \\>12% and \\>200 mL from baseline within 30 minutes (min) after inhalation of 400 µg salbutamol (i.e. albuterol) pMDI at the Screening Visit (V1).\n\nExclusion Criteria:\n\n* History of near fatal asthma or hospitalisation for asthma in intensive care unit, inpatient setting or emergency room access for asthma in the previous 6 months prior to screening, which in the judgement of the Investigator may place the subjects at undue risk;\n* Recent asthma exacerbation requiring systemic corticosteroids (SCSs), or emergency room admission or hospitalisation within 3 months prior to screening and\u002For during the run-in period ;\n* Non-persistent asthma: exercise-induced, seasonal asthma (as the only asthma-related diagnosis) not requiring daily asthma control medicine;\n* Asthma subjects currently treated with any of the following :\n\n  1. High dose ICS;\n  2. Long-acting muscarinic antagonist (LAMA);\n  3. Systemic, depot or slow-release corticosteroids within 12 weeks prior to screening;\n  4. Any other asthma treatments (e.g. cromolyn sodium, nedocromil sodium, leukotriene modifiers) within 4 weeks prior to screening;\n  5. Any biologic therapy (e.g. omalizumab, mepolizumab, reslizumab, benralizumab, dupilumab, tezepelumab) within 6 months prior to screening;\n* Respiratory disorders other than asthma\n* Lung resection;\n* Lower respiratory tract infection;\n* Lung cancer and history of lung cancer;\n* Subjects with active cancer or a history of cancer (other than lungs) ;\n* Patients who have clinically significant cardiovascular condition;\n* Run-in compliance: e-Diary completion \\\u003C75% and run-in treatment compliance \\\u003C75% at randomisation;","ALL","18 Years","75 Years",{"count":1870,"type":1871},780,"ESTIMATED","INTERVENTIONAL",[1874],"PHASE2","This study will compare an asthma inhaler that uses a new climate friendly alternative propellant to an asthma inhaler with an existing propellant. We want to make sure both versions of the inhaler work the same way for people with mild to moderate asthma.",[1877],"Asthma","2026-06-24",{"date":1880,"type":1881},"2026-06-25","ACTUAL",{"date":1883,"type":1881},"2025-12-17",{"date":1885,"type":1871},"2027-06-03",{"name":5,"class":6},167]