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00","fahim.ebrahimi@clarunis.ch",[39,58,71],{"facility":40,"status":41,"city":42,"state":11,"zip":43,"country":44,"countryCode":45,"cosmosGeoPoint":46,"geoPoint":51,"contacts":52},"University Hospital Basel","RECRUITING","Basel","4031","Switzerland","CH",{"type":47,"coordinates":48},"Point",[49,50],7.57327,47.55839,{"lat":50,"lon":49},[53,55],{"name":31,"role":35,"phone":54,"phoneExt":11,"email":37},"+41 61 777 74 38",{"name":56,"role":57,"phone":11,"phoneExt":11,"email":11},"Markus Heim, Prof.","PRINCIPAL_INVESTIGATOR",{"facility":59,"status":41,"city":60,"state":11,"zip":61,"country":44,"countryCode":45,"cosmosGeoPoint":62,"geoPoint":66,"contacts":67},"Hôpitaux Universitaires de Genève","Geneva","1205",{"type":47,"coordinates":63},[64,65],6.14569,46.20222,{"lat":65,"lon":64},[68,70],{"name":69,"role":35,"phone":11,"phoneExt":11,"email":11},"Nicolas Goossens, PD Dr.",{"name":69,"role":57,"phone":11,"phoneExt":11,"email":11},{"facility":72,"status":41,"city":73,"state":11,"zip":74,"country":44,"countryCode":45,"cosmosGeoPoint":75,"geoPoint":79,"contacts":80},"Kantonsspital St. Gallen","Sankt Gallen","9007",{"type":47,"coordinates":76},[77,78],9.37477,47.42391,{"lat":78,"lon":77},[81,83],{"name":82,"role":35,"phone":11,"phoneExt":11,"email":11},"David Semela, PD Dr.",{"name":82,"role":57,"phone":11,"phoneExt":11,"email":11},{"type":85,"investigatorFullName":11,"investigatorTitle":11,"investigatorAffiliation":11,"oldNameTitle":11,"oldOrganization":11},"SPONSOR","100616231",false,"NCT07302919","Transarterial Chemoembolization (TACE) Plus ABCB1 Inhibition Versus TACE Alone in Patients With Hepatocellular Carcinoma","Randomized, Double-Blind, Parallel, Controlled, Multicenter Study of Transarterial Chemoembolization (TACE) Plus ABCB1 Inhibition Versus TACE Alone in Patients With Hepatocellular Carcinoma: IMPACT-TACE","IMPACT-TACE","Inclusion 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in Renal Disease) formula,\n* Myocardial infarction within the last 6 months,\n* Life expectancy \\\u003C12 weeks,\n* Contraindications to the class of drugs under study, e.g., known hypersensitivity or allergy to calcium antagonists,\n* Inability to follow the procedures of the study, e.g., due to language problems, psychological disorders, dementia, etc. of the participant,\n* Pregnancy or breastfeeding, or intention of becoming pregnant during study treatment or within at least 3 months after the TACE treatment.","ALL","18 Years",{"count":96,"type":97},152,"ESTIMATED","INTERVENTIONAL",[100,101],"PHASE2","PHASE3","IMPACT-TACE is an investigator-initiated, prospective, multicenter, randomized, double-blinded, interventional trial to test the hypothesis that the simultaneous application of doxorubicin with the ABCB1 inhibitor nicardipine would significantly improve the success rate of TACE treatment.",[104],"Hepato Cellular Carcinoma (HCC)",[106],"Transarterial Chemoembolization 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