[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100550734":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":28,"centralContacts":32,"locations":38,"responsibleParty":82,"collaborators":25,"id":84,"slug":25,"hasResults":85,"nctId":86,"briefTitle":87,"officialTitle":88,"acronym":25,"eligibilityCriteria":89,"healthyVolunteers":85,"sex":90,"minAge":25,"maxAge":25,"enrollmentInfo":91,"targetDuration":25,"studyType":94,"phases":95,"briefSummary":97,"conditions":98,"keywords":25,"overallStatus":41,"whyStopped":25,"lastUpdateSubmitDate":102,"lastUpdatePostDateStruct":103,"startDateStruct":106,"completionDateStruct":108,"leadSponsor":110,"locationsCount":111},{"fullName":5,"class":6},"Children's Hospital Medical Center, Cincinnati","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Vitamin A","ACTIVE_COMPARATOR","Route of administration: Oral. Frequency: Once. Timing: Pre-transplant Dose of Vit A: 1.2 mg\u002Fkg, max dose 75 mg Formulation of Vit A: 2.5 mg liquid filled oral capsules.\n\nVitamin A level assessment: Vitamin A levels will be measured pre-transplant and again at day +30 (± 10 days)",[13],"Drug: Vitamin A",{"label":15,"type":16,"description":17,"interventionNames":18},"Placebo","PLACEBO_COMPARATOR","Placebo pills containing microcrystalline cellulose will be dispensed in patients who are randomized to the placebo arm.",[19],"Other: Placebo",[21,26],{"type":22,"name":9,"description":23,"armGroupLabels":24,"otherNames":25},"DRUG","Enrolled subjects will receive one observed oral vitamin A dose, prior to their HSCT, in the outpatient clinic or inpatient Bone Marrow Transplant (BMT) floor.",[9],null,{"type":6,"name":15,"description":17,"armGroupLabels":27,"otherNames":25},[15],[29],{"name":30,"affiliation":5,"role":31},"Pooja Khandelwal, MD","PRINCIPAL_INVESTIGATOR",[33],{"name":34,"role":35,"phone":36,"phoneExt":25,"email":37},"Celeste Dourson, MS, CCRP","CONTACT","513-636-7679","celeste.dourson@cchmc.org",[39,56,69],{"facility":40,"status":41,"city":42,"state":43,"zip":44,"country":45,"countryCode":46,"cosmosGeoPoint":47,"geoPoint":52,"contacts":53},"Moffitt Cancer Center","RECRUITING","Tampa","Florida","33612","United States","US",{"type":48,"coordinates":49},"Point",[50,51],-82.45843,27.94752,{"lat":51,"lon":50},[54],{"name":55,"role":31,"phone":25,"phoneExt":25,"email":25},"Nelli Bejanyan, MD",{"facility":57,"status":41,"city":58,"state":59,"zip":60,"country":45,"countryCode":46,"cosmosGeoPoint":61,"geoPoint":65,"contacts":66},"Roswell Park Comprehensive Cancer Center","Buffalo","New York","14203",{"type":48,"coordinates":62},[63,64],-78.87837,42.88645,{"lat":64,"lon":63},[67],{"name":68,"role":31,"phone":25,"phoneExt":25,"email":25},"Theresa Hahn, PhD",{"facility":70,"status":41,"city":71,"state":72,"zip":73,"country":45,"countryCode":46,"cosmosGeoPoint":74,"geoPoint":78,"contacts":79},"The Ohio State University","Columbus","Ohio","43210",{"type":48,"coordinates":75},[76,77],-82.99879,39.96118,{"lat":77,"lon":76},[80],{"name":81,"role":31,"phone":25,"phoneExt":25,"email":25},"Sumithira Vasu, MD",{"type":83,"investigatorFullName":25,"investigatorTitle":25,"investigatorAffiliation":25,"oldNameTitle":25,"oldOrganization":25},"SPONSOR","100550734",false,"NCT06450925","Vitamin A Supplementation in Allogeneic Stem Cell Transplantation.","A Randomized Double Blinded Trial of Vitamin A Supplementation in Allogeneic Stem Cell Transplantation.","Inclusion Criteria:\n\n* Be 18 years of age or older\n* Be scheduled for allogeneic stem cell transplant.\n* Have a vitamin A level \\\u003C upper limit of normal for age.\n* Be able to tolerate enteral vitamin dose administration.\n* Have a total bilirubin level \\\u003C 1.5x ULN and an AST and\u002For ALT\\\u003C 3xULN for age\n* Receiving PBSCs as stem cell graft\n\nExclusion Criteria:\n\n* Ongoing raised intracranial pressure\n* Liver cirrhosis\n* Patients will be excluded if they are currently pregnant.","ALL",{"count":92,"type":93},190,"ESTIMATED","INTERVENTIONAL",[96],"PHASE2","The investigators hypothesize that single oral high dose supplementation with vitamin A will reduce the incidence of moderate-severe chronic graft-versus-host disease (GVHD) compared with placebo.",[99,100,101],"Graft Vs Host Disease","Vitamin A Deficiency","Vitamin D Deficiency","2025-08-11",{"date":104,"type":105},"2025-08-12","ACTUAL",{"date":107,"type":105},"2025-03-25",{"date":109,"type":93},"2029-08",{"name":5,"class":6},3]