[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100590468":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":27,"centralContacts":31,"locations":41,"responsibleParty":837,"collaborators":23,"id":839,"slug":23,"hasResults":840,"nctId":841,"briefTitle":842,"officialTitle":843,"acronym":23,"eligibilityCriteria":844,"healthyVolunteers":840,"sex":845,"minAge":846,"maxAge":23,"enrollmentInfo":847,"targetDuration":23,"studyType":850,"phases":851,"briefSummary":853,"conditions":854,"keywords":856,"overallStatus":44,"whyStopped":23,"lastUpdateSubmitDate":865,"lastUpdatePostDateStruct":866,"startDateStruct":869,"completionDateStruct":871,"leadSponsor":873,"locationsCount":874},{"fullName":5,"class":6},"Mediar Therapeutics","INDUSTRY",[8,13],{"label":9,"type":10,"description":9,"interventionNames":11},"MTX-463","EXPERIMENTAL",[12],"Biological: MTX-463",{"label":14,"type":15,"description":14,"interventionNames":16},"Placebo","PLACEBO_COMPARATOR",[17],"Other: Placebo",[19,24],{"type":20,"name":9,"description":21,"armGroupLabels":22,"otherNames":23},"BIOLOGICAL","MTX-463 is an immunoglobin G1 (IgG1) monoclonal antibody directed against WNT-inducible signaling pathway protein 1 (WISP1). WISP1 (aka CCN-4) is a matricellular protein that appears to be upregulated locally in response to certain chronic diseases, including IPF, and malignancies.",[9],null,{"type":25,"name":14,"description":14,"armGroupLabels":26,"otherNames":23},"OTHER",[14],[28],{"name":29,"affiliation":5,"role":30},"Todd Astor, MD","STUDY_CHAIR",[32,38],{"name":33,"role":34,"phone":35,"phoneExt":36,"email":37},"Jeffrey Bornstein, MD","CONTACT","(617) 936-0960","803","Jeffrey@mediartx.com",{"name":39,"role":34,"phone":35,"phoneExt":40,"email":23},"Katherine Palu","810",[42,61,73,85,96,107,119,131,143,155,167,179,191,203,215,227,238,249,261,272,284,296,308,320,332,344,356,369,380,391,402,413,423,430,443,454,465,476,489,500,513,524,535,546,553,564,575,589,601,613,626,639,650,661,672,685,696,707,718,731,744,751,762,773,781,792,804,815,826],{"facility":43,"status":44,"city":45,"state":46,"zip":47,"country":48,"countryCode":49,"cosmosGeoPoint":50,"geoPoint":55,"contacts":56},"WISPer Site in Birmingham, AL","RECRUITING","Birmingham","Alabama","35233","United States","US",{"type":51,"coordinates":52},"Point",[53,54],-86.80249,33.52066,{"lat":54,"lon":53},[57],{"name":58,"role":34,"phone":59,"phoneExt":23,"email":60},"WISPer Contact","617-802-6568","wisper@mediartx.com",{"facility":62,"status":44,"city":63,"state":64,"zip":65,"country":48,"countryCode":49,"cosmosGeoPoint":66,"geoPoint":70,"contacts":71},"WISPer site in Phoenix, AZ","Phoenix","Arizona","85032",{"type":51,"coordinates":67},[68,69],-112.07404,33.44838,{"lat":69,"lon":68},[72],{"name":58,"role":34,"phone":59,"phoneExt":23,"email":60},{"facility":74,"status":44,"city":75,"state":76,"zip":77,"country":48,"countryCode":49,"cosmosGeoPoint":78,"geoPoint":82,"contacts":83},"WISPer Site in Los Angeles, CA","Los Angeles","California","90033",{"type":51,"coordinates":79},[80,81],-118.24368,34.05223,{"lat":81,"lon":80},[84],{"name":58,"role":34,"phone":59,"phoneExt":23,"email":60},{"facility":86,"status":44,"city":87,"state":76,"zip":88,"country":48,"countryCode":49,"cosmosGeoPoint":89,"geoPoint":93,"contacts":94},"WISPer site in Newport Beach, CA","Newport Beach","92663",{"type":51,"coordinates":90},[91,92],-117.92895,33.61891,{"lat":92,"lon":91},[95],{"name":58,"role":34,"phone":59,"phoneExt":23,"email":60},{"facility":97,"status":44,"city":98,"state":76,"zip":99,"country":48,"countryCode":49,"cosmosGeoPoint":100,"geoPoint":104,"contacts":105},"WISPer Site in Palm Springs, CA","Palm Springs","92203",{"type":51,"coordinates":101},[102,103],-116.54529,33.8303,{"lat":103,"lon":102},[106],{"name":58,"role":34,"phone":59,"phoneExt":23,"email":60},{"facility":108,"status":44,"city":109,"state":110,"zip":111,"country":48,"countryCode":49,"cosmosGeoPoint":112,"geoPoint":116,"contacts":117},"WISPer Site in Denver, CO","Denver","Colorado","80206",{"type":51,"coordinates":113},[114,115],-104.9847,39.73915,{"lat":115,"lon":114},[118],{"name":58,"role":34,"phone":59,"phoneExt":23,"email":60},{"facility":120,"status":44,"city":121,"state":122,"zip":123,"country":48,"countryCode":49,"cosmosGeoPoint":124,"geoPoint":128,"contacts":129},"WISPer site in Loxahatchee, FL","Loxahatchee Groves","Florida","33470",{"type":51,"coordinates":125},[126,127],-80.27977,26.68368,{"lat":127,"lon":126},[130],{"name":58,"role":34,"phone":59,"phoneExt":23,"email":60},{"facility":132,"status":44,"city":133,"state":134,"zip":135,"country":48,"countryCode":49,"cosmosGeoPoint":136,"geoPoint":140,"contacts":141},"WISPer Site in Atlanta, GA","Atlanta","Georgia","30322",{"type":51,"coordinates":137},[138,139],-84.38798,33.749,{"lat":139,"lon":138},[142],{"name":58,"role":34,"phone":59,"phoneExt":23,"email":60},{"facility":144,"status":44,"city":145,"state":146,"zip":147,"country":48,"countryCode":49,"cosmosGeoPoint":148,"geoPoint":152,"contacts":153},"WISPer site in Champaign, IL","Champaign","Illinois","61822",{"type":51,"coordinates":149},[150,151],-88.24338,40.11642,{"lat":151,"lon":150},[154],{"name":58,"role":34,"phone":59,"phoneExt":23,"email":60},{"facility":156,"status":44,"city":157,"state":158,"zip":159,"country":48,"countryCode":49,"cosmosGeoPoint":160,"geoPoint":164,"contacts":165},"WISPer site in Kansas City, KS","Kansas City","Kansas","66160",{"type":51,"coordinates":161},[162,163],-94.62746,39.11417,{"lat":163,"lon":162},[166],{"name":58,"role":34,"phone":59,"phoneExt":23,"email":60},{"facility":168,"status":44,"city":169,"state":170,"zip":171,"country":48,"countryCode":49,"cosmosGeoPoint":172,"geoPoint":176,"contacts":177},"WISPer Site in Louisville, KY","Louisville","Kentucky","40202",{"type":51,"coordinates":173},[174,175],-85.75941,38.25424,{"lat":175,"lon":174},[178],{"name":58,"role":34,"phone":59,"phoneExt":23,"email":60},{"facility":180,"status":44,"city":181,"state":182,"zip":183,"country":48,"countryCode":49,"cosmosGeoPoint":184,"geoPoint":188,"contacts":189},"WISPer site in Shreveport, LA","Shreveport","Louisiana","71103",{"type":51,"coordinates":185},[186,187],-93.75018,32.52515,{"lat":187,"lon":186},[190],{"name":58,"role":34,"phone":59,"phoneExt":23,"email":60},{"facility":192,"status":44,"city":193,"state":194,"zip":195,"country":48,"countryCode":49,"cosmosGeoPoint":196,"geoPoint":200,"contacts":201},"WISPer Site in Baltimore, MD","Baltimore","Maryland","21224",{"type":51,"coordinates":197},[198,199],-76.61219,39.29038,{"lat":199,"lon":198},[202],{"name":58,"role":34,"phone":59,"phoneExt":23,"email":60},{"facility":204,"status":44,"city":205,"state":206,"zip":207,"country":48,"countryCode":49,"cosmosGeoPoint":208,"geoPoint":212,"contacts":213},"WISPer Site in Boston, MA","Boston","Massachusetts","02114",{"type":51,"coordinates":209},[210,211],-71.05977,42.35843,{"lat":211,"lon":210},[214],{"name":58,"role":34,"phone":59,"phoneExt":23,"email":60},{"facility":216,"status":44,"city":217,"state":218,"zip":219,"country":48,"countryCode":49,"cosmosGeoPoint":220,"geoPoint":224,"contacts":225},"WISPer Site in Ann Arbor, MI","Ann Arbor","Michigan","48209",{"type":51,"coordinates":221},[222,223],-83.74088,42.27756,{"lat":223,"lon":222},[226],{"name":58,"role":34,"phone":59,"phoneExt":23,"email":60},{"facility":228,"status":44,"city":229,"state":218,"zip":230,"country":48,"countryCode":49,"cosmosGeoPoint":231,"geoPoint":235,"contacts":236},"WISPer Site in Detroit, MI","Detroit","48202",{"type":51,"coordinates":232},[233,234],-83.04575,42.33143,{"lat":234,"lon":233},[237],{"name":58,"role":34,"phone":59,"phoneExt":23,"email":60},{"facility":239,"status":44,"city":240,"state":240,"zip":241,"country":48,"countryCode":49,"cosmosGeoPoint":242,"geoPoint":246,"contacts":247},"WISPer site in New York, NY","New York","10032",{"type":51,"coordinates":243},[244,245],-74.00597,40.71427,{"lat":245,"lon":244},[248],{"name":58,"role":34,"phone":59,"phoneExt":23,"email":60},{"facility":250,"status":44,"city":251,"state":252,"zip":253,"country":48,"countryCode":49,"cosmosGeoPoint":254,"geoPoint":258,"contacts":259},"WISPer Site in Durham, NC","Durham","North Carolina","27710",{"type":51,"coordinates":255},[256,257],-78.89862,35.99403,{"lat":257,"lon":256},[260],{"name":58,"role":34,"phone":59,"phoneExt":23,"email":60},{"facility":262,"status":44,"city":263,"state":252,"zip":264,"country":48,"countryCode":49,"cosmosGeoPoint":265,"geoPoint":269,"contacts":270},"WISPer site in Greensboro, NC","Greensboro","27403",{"type":51,"coordinates":266},[267,268],-79.79198,36.07264,{"lat":268,"lon":267},[271],{"name":58,"role":34,"phone":59,"phoneExt":23,"email":60},{"facility":273,"status":44,"city":274,"state":275,"zip":276,"country":48,"countryCode":49,"cosmosGeoPoint":277,"geoPoint":281,"contacts":282},"WISPer site in Oklahoma City, OK","Oklahoma City","Oklahoma","73104",{"type":51,"coordinates":278},[279,280],-97.51643,35.46756,{"lat":280,"lon":279},[283],{"name":58,"role":34,"phone":59,"phoneExt":23,"email":60},{"facility":285,"status":44,"city":286,"state":287,"zip":288,"country":48,"countryCode":49,"cosmosGeoPoint":289,"geoPoint":293,"contacts":294},"WISPer Site in Pittsburg, PA","Pittsburgh","Pennsylvania","15213",{"type":51,"coordinates":290},[291,292],-79.99589,40.44062,{"lat":292,"lon":291},[295],{"name":58,"role":34,"phone":59,"phoneExt":23,"email":60},{"facility":297,"status":44,"city":298,"state":299,"zip":300,"country":48,"countryCode":49,"cosmosGeoPoint":301,"geoPoint":305,"contacts":306},"WISPer Site in Charleston, SC","Charleston","South Carolina","29425",{"type":51,"coordinates":302},[303,304],-79.93275,32.77632,{"lat":304,"lon":303},[307],{"name":58,"role":34,"phone":59,"phoneExt":23,"email":60},{"facility":309,"status":44,"city":310,"state":311,"zip":312,"country":48,"countryCode":49,"cosmosGeoPoint":313,"geoPoint":317,"contacts":318},"WISPer Site in Nashville, TN","Nashville","Tennessee","37204",{"type":51,"coordinates":314},[315,316],-86.78444,36.16589,{"lat":316,"lon":315},[319],{"name":58,"role":34,"phone":59,"phoneExt":23,"email":60},{"facility":321,"status":44,"city":322,"state":323,"zip":324,"country":48,"countryCode":49,"cosmosGeoPoint":325,"geoPoint":329,"contacts":330},"WISPer site in Dallas, TX","Dallas","Texas","75204",{"type":51,"coordinates":326},[327,328],-96.80667,32.78306,{"lat":328,"lon":327},[331],{"name":58,"role":34,"phone":59,"phoneExt":23,"email":60},{"facility":333,"status":44,"city":334,"state":335,"zip":336,"country":48,"countryCode":49,"cosmosGeoPoint":337,"geoPoint":341,"contacts":342},"WISPer Site in Salt Lake City, UT","Salt Lake City","Utah","84103",{"type":51,"coordinates":338},[339,340],-111.89105,40.76078,{"lat":340,"lon":339},[343],{"name":58,"role":34,"phone":59,"phoneExt":23,"email":60},{"facility":345,"status":44,"city":346,"state":347,"zip":348,"country":48,"countryCode":49,"cosmosGeoPoint":349,"geoPoint":353,"contacts":354},"WISPer Site in Wilwaukee, WI","Milwaukee","Wisconsin","52226",{"type":51,"coordinates":350},[351,352],-87.90647,43.0389,{"lat":352,"lon":351},[355],{"name":58,"role":34,"phone":59,"phoneExt":23,"email":60},{"facility":357,"status":44,"city":358,"state":23,"zip":359,"country":360,"countryCode":361,"cosmosGeoPoint":362,"geoPoint":366,"contacts":367},"WISPer Site in Buenos Aires, Argentina","Buenos Aires","B1602DQD","Argentina","AR",{"type":51,"coordinates":363},[364,365],-58.37723,-34.61315,{"lat":365,"lon":364},[368],{"name":58,"role":34,"phone":59,"phoneExt":23,"email":60},{"facility":370,"status":44,"city":371,"state":23,"zip":372,"country":360,"countryCode":361,"cosmosGeoPoint":373,"geoPoint":377,"contacts":378},"WISPer Site in Cordoba, Argentina","Córdoba","X5003DCE",{"type":51,"coordinates":374},[375,376],-64.18853,-31.40648,{"lat":376,"lon":375},[379],{"name":58,"role":34,"phone":59,"phoneExt":23,"email":60},{"facility":381,"status":44,"city":382,"state":23,"zip":383,"country":360,"countryCode":361,"cosmosGeoPoint":384,"geoPoint":388,"contacts":389},"WISPer Site in Mendoza, Argentina","Mendoza","M5500",{"type":51,"coordinates":385},[386,387],-68.84582,-32.88946,{"lat":387,"lon":386},[390],{"name":58,"role":34,"phone":59,"phoneExt":23,"email":60},{"facility":392,"status":44,"city":393,"state":23,"zip":394,"country":360,"countryCode":361,"cosmosGeoPoint":395,"geoPoint":399,"contacts":400},"WISPer Site in Rosario, Argentina","Rosario","S2000DBS",{"type":51,"coordinates":396},[397,398],-60.63932,-32.94682,{"lat":398,"lon":397},[401],{"name":58,"role":34,"phone":59,"phoneExt":23,"email":60},{"facility":403,"status":44,"city":404,"state":23,"zip":405,"country":360,"countryCode":361,"cosmosGeoPoint":406,"geoPoint":410,"contacts":411},"WISPer Site in San Miguel De Tucumán, Argentina","San Miguel de Tucumán","T4000IAI",{"type":51,"coordinates":407},[408,409],-65.21051,-26.81601,{"lat":409,"lon":408},[412],{"name":58,"role":34,"phone":59,"phoneExt":23,"email":60},{"facility":414,"status":44,"city":415,"state":23,"zip":394,"country":360,"countryCode":361,"cosmosGeoPoint":416,"geoPoint":420,"contacts":421},"WISPer Site in Santa Fe, Argentina","Santa Fe",{"type":51,"coordinates":417},[418,419],-60.70868,-31.64881,{"lat":419,"lon":418},[422],{"name":58,"role":34,"phone":59,"phoneExt":23,"email":60},{"facility":414,"status":44,"city":415,"state":23,"zip":424,"country":360,"countryCode":361,"cosmosGeoPoint":425,"geoPoint":427,"contacts":428},"S3000ASF",{"type":51,"coordinates":426},[418,419],{"lat":419,"lon":418},[429],{"name":58,"role":34,"phone":59,"phoneExt":23,"email":60},{"facility":431,"status":44,"city":432,"state":23,"zip":433,"country":434,"countryCode":435,"cosmosGeoPoint":436,"geoPoint":440,"contacts":441},"WISPer site in Greenslopes, Australia","Greenslopes","4120","Australia","AU",{"type":51,"coordinates":437},[438,439],153.04951,-27.50815,{"lat":439,"lon":438},[442],{"name":58,"role":34,"phone":59,"phoneExt":23,"email":60},{"facility":444,"status":44,"city":445,"state":23,"zip":446,"country":434,"countryCode":435,"cosmosGeoPoint":447,"geoPoint":451,"contacts":452},"WISPer site in Melbourne, Australia","Melbourne","3004",{"type":51,"coordinates":448},[449,450],144.96332,-37.814,{"lat":450,"lon":449},[453],{"name":58,"role":34,"phone":59,"phoneExt":23,"email":60},{"facility":455,"status":44,"city":456,"state":23,"zip":457,"country":434,"countryCode":435,"cosmosGeoPoint":458,"geoPoint":462,"contacts":463},"WISPer site in Midland, Australia","Midland","6056",{"type":51,"coordinates":459},[460,461],116.0107,-31.88909,{"lat":461,"lon":460},[464],{"name":58,"role":34,"phone":59,"phoneExt":23,"email":60},{"facility":466,"status":44,"city":467,"state":23,"zip":468,"country":434,"countryCode":435,"cosmosGeoPoint":469,"geoPoint":473,"contacts":474},"WISPer site in Westmead, Australia","Westmead","2145",{"type":51,"coordinates":470},[471,472],150.98768,-33.80383,{"lat":472,"lon":471},[475],{"name":58,"role":34,"phone":59,"phoneExt":23,"email":60},{"facility":477,"status":44,"city":478,"state":23,"zip":479,"country":480,"countryCode":481,"cosmosGeoPoint":482,"geoPoint":486,"contacts":487},"WISPer Site in Brussels, Belgium","Brussels","1200","Belgium","BE",{"type":51,"coordinates":483},[484,485],4.34878,50.85045,{"lat":485,"lon":484},[488],{"name":58,"role":34,"phone":59,"phoneExt":23,"email":60},{"facility":490,"status":44,"city":491,"state":23,"zip":492,"country":480,"countryCode":481,"cosmosGeoPoint":493,"geoPoint":497,"contacts":498},"WISPer Site in Edegem, Belgium","Edegem","2650",{"type":51,"coordinates":494},[495,496],4.44504,51.15662,{"lat":496,"lon":495},[499],{"name":58,"role":34,"phone":59,"phoneExt":23,"email":60},{"facility":501,"status":44,"city":502,"state":23,"zip":503,"country":504,"countryCode":505,"cosmosGeoPoint":506,"geoPoint":510,"contacts":511},"WISPer Site in Belo Horizonte, Brazil","Belo Horizonte","30110","Brazil","BR",{"type":51,"coordinates":507},[508,509],-43.93778,-19.92083,{"lat":509,"lon":508},[512],{"name":58,"role":34,"phone":59,"phoneExt":23,"email":60},{"facility":514,"status":44,"city":515,"state":23,"zip":516,"country":504,"countryCode":505,"cosmosGeoPoint":517,"geoPoint":521,"contacts":522},"WISPer Site in Curitiba, Brazil","Curitiba","80060",{"type":51,"coordinates":518},[519,520],-49.27306,-25.42778,{"lat":520,"lon":519},[523],{"name":58,"role":34,"phone":59,"phoneExt":23,"email":60},{"facility":525,"status":44,"city":526,"state":23,"zip":527,"country":504,"countryCode":505,"cosmosGeoPoint":528,"geoPoint":532,"contacts":533},"WISPer Site in Passo Fundo, Brazil","Passo Fundo","99010",{"type":51,"coordinates":529},[530,531],-52.40667,-28.26278,{"lat":531,"lon":530},[534],{"name":58,"role":34,"phone":59,"phoneExt":23,"email":60},{"facility":536,"status":44,"city":537,"state":23,"zip":538,"country":504,"countryCode":505,"cosmosGeoPoint":539,"geoPoint":543,"contacts":544},"WISPer Site in Porto Alegre, Brazil","Porto Alegre","90035",{"type":51,"coordinates":540},[541,542],-51.23019,-30.03283,{"lat":542,"lon":541},[545],{"name":58,"role":34,"phone":59,"phoneExt":23,"email":60},{"facility":536,"status":44,"city":537,"state":23,"zip":547,"country":504,"countryCode":505,"cosmosGeoPoint":548,"geoPoint":550,"contacts":551},"90410",{"type":51,"coordinates":549},[541,542],{"lat":542,"lon":541},[552],{"name":58,"role":34,"phone":59,"phoneExt":23,"email":60},{"facility":554,"status":44,"city":555,"state":23,"zip":556,"country":504,"countryCode":505,"cosmosGeoPoint":557,"geoPoint":561,"contacts":562},"WISP Site in São Bernardo Do Campo, Brazil","São Bernardo do Campo","09715",{"type":51,"coordinates":558},[559,560],-46.565,-23.69389,{"lat":560,"lon":559},[563],{"name":58,"role":34,"phone":59,"phoneExt":23,"email":60},{"facility":565,"status":44,"city":566,"state":23,"zip":567,"country":504,"countryCode":505,"cosmosGeoPoint":568,"geoPoint":572,"contacts":573},"WISPer Site in Sao Paulo, Brazil","São Paulo","05403",{"type":51,"coordinates":569},[570,571],-46.63611,-23.5475,{"lat":571,"lon":570},[574],{"name":58,"role":34,"phone":59,"phoneExt":23,"email":60},{"facility":576,"status":44,"city":577,"state":578,"zip":579,"country":580,"countryCode":581,"cosmosGeoPoint":582,"geoPoint":586,"contacts":587},"WISPer Site in Calgary, Alberta","Calgary","Alberta","T2N 4Z5","Canada","CA",{"type":51,"coordinates":583},[584,585],-114.08529,51.05011,{"lat":585,"lon":584},[588],{"name":58,"role":34,"phone":59,"phoneExt":23,"email":60},{"facility":590,"status":44,"city":591,"state":592,"zip":593,"country":580,"countryCode":581,"cosmosGeoPoint":594,"geoPoint":598,"contacts":599},"WISPer site in Ajax, ON","Ajax","Ontario","L1S 2J5",{"type":51,"coordinates":595},[596,597],-79.03288,43.85012,{"lat":597,"lon":596},[600],{"name":58,"role":34,"phone":59,"phoneExt":23,"email":60},{"facility":602,"status":44,"city":603,"state":604,"zip":605,"country":580,"countryCode":581,"cosmosGeoPoint":606,"geoPoint":610,"contacts":611},"WISPer site in Trois-Rivières, Quebec","Trois-Rivières","Quebec","G8T 7A1",{"type":51,"coordinates":607},[608,609],-72.5477,46.34515,{"lat":609,"lon":608},[612],{"name":58,"role":34,"phone":59,"phoneExt":23,"email":60},{"facility":614,"status":44,"city":615,"state":23,"zip":616,"country":617,"countryCode":618,"cosmosGeoPoint":619,"geoPoint":623,"contacts":624},"WISPer Site in Split","Split","21000","Croatia","HR",{"type":51,"coordinates":620},[621,622],16.43915,43.50891,{"lat":622,"lon":621},[625],{"name":58,"role":34,"phone":59,"phoneExt":23,"email":60},{"facility":627,"status":44,"city":628,"state":23,"zip":629,"country":630,"countryCode":631,"cosmosGeoPoint":632,"geoPoint":636,"contacts":637},"WISPer Site in Nantes, France","Nantes","44800","France","FR",{"type":51,"coordinates":633},[634,635],-1.55336,47.21725,{"lat":635,"lon":634},[638],{"name":58,"role":34,"phone":59,"phoneExt":23,"email":60},{"facility":640,"status":44,"city":641,"state":23,"zip":642,"country":630,"countryCode":631,"cosmosGeoPoint":643,"geoPoint":647,"contacts":648},"WISPer Site in Nice, France","Nice","06001",{"type":51,"coordinates":644},[645,646],7.26608,43.70313,{"lat":646,"lon":645},[649],{"name":58,"role":34,"phone":59,"phoneExt":23,"email":60},{"facility":651,"status":44,"city":652,"state":23,"zip":653,"country":630,"countryCode":631,"cosmosGeoPoint":654,"geoPoint":658,"contacts":659},"WISPer Site in Paris, France","Paris","75015",{"type":51,"coordinates":655},[656,657],2.3488,48.85341,{"lat":657,"lon":656},[660],{"name":58,"role":34,"phone":59,"phoneExt":23,"email":60},{"facility":662,"status":44,"city":663,"state":23,"zip":664,"country":630,"countryCode":631,"cosmosGeoPoint":665,"geoPoint":669,"contacts":670},"WISPer Site in Rennes, France","Rennes","35033",{"type":51,"coordinates":666},[667,668],-1.67431,48.11109,{"lat":668,"lon":667},[671],{"name":58,"role":34,"phone":59,"phoneExt":23,"email":60},{"facility":673,"status":44,"city":674,"state":23,"zip":675,"country":676,"countryCode":677,"cosmosGeoPoint":678,"geoPoint":682,"contacts":683},"WISPer Site in Abbotstown, Ireland","Abbotstown","D15 X40D","Ireland","IE",{"type":51,"coordinates":679},[680,681],-6.23614,53.34533,{"lat":681,"lon":680},[684],{"name":58,"role":34,"phone":59,"phoneExt":23,"email":60},{"facility":686,"status":44,"city":687,"state":23,"zip":688,"country":676,"countryCode":677,"cosmosGeoPoint":689,"geoPoint":693,"contacts":694},"WISPer Site in Drogheda, Ireland","Drogheda","F92VW28",{"type":51,"coordinates":690},[691,692],-6.34778,53.71889,{"lat":692,"lon":691},[695],{"name":58,"role":34,"phone":59,"phoneExt":23,"email":60},{"facility":697,"status":44,"city":698,"state":23,"zip":699,"country":676,"countryCode":677,"cosmosGeoPoint":700,"geoPoint":704,"contacts":705},"WISPer Site in Dublin, Ireland","Dublin","D24 NR0A",{"type":51,"coordinates":701},[702,703],-6.24889,53.33306,{"lat":703,"lon":702},[706],{"name":58,"role":34,"phone":59,"phoneExt":23,"email":60},{"facility":708,"status":44,"city":709,"state":23,"zip":710,"country":676,"countryCode":677,"cosmosGeoPoint":711,"geoPoint":715,"contacts":716},"WISPer Site in Letterkenny, Ireland","Letterkenny","F92 AE81",{"type":51,"coordinates":712},[713,714],-7.73333,54.95,{"lat":714,"lon":713},[717],{"name":58,"role":34,"phone":59,"phoneExt":23,"email":60},{"facility":719,"status":44,"city":720,"state":23,"zip":721,"country":722,"countryCode":723,"cosmosGeoPoint":724,"geoPoint":728,"contacts":729},"WISPer Site in Nieuwegein, Netherlands","Nieuwegein","3435CM","Netherlands","NL",{"type":51,"coordinates":725},[726,727],5.08056,52.02917,{"lat":727,"lon":726},[730],{"name":58,"role":34,"phone":59,"phoneExt":23,"email":60},{"facility":732,"status":44,"city":733,"state":23,"zip":734,"country":735,"countryCode":736,"cosmosGeoPoint":737,"geoPoint":741,"contacts":742},"WISPer Site in Barcelona, Spain","Barcelona","08017","Spain","ES",{"type":51,"coordinates":738},[739,740],2.15899,41.38879,{"lat":740,"lon":739},[743],{"name":58,"role":34,"phone":59,"phoneExt":23,"email":60},{"facility":732,"status":44,"city":733,"state":23,"zip":745,"country":735,"countryCode":736,"cosmosGeoPoint":746,"geoPoint":748,"contacts":749},"08036",{"type":51,"coordinates":747},[739,740],{"lat":740,"lon":739},[750],{"name":58,"role":34,"phone":59,"phoneExt":23,"email":60},{"facility":752,"status":44,"city":753,"state":23,"zip":754,"country":735,"countryCode":736,"cosmosGeoPoint":755,"geoPoint":759,"contacts":760},"WISPer Site in Lugo, Spain","Lugo","27003",{"type":51,"coordinates":756},[757,758],-7.55602,43.00992,{"lat":758,"lon":757},[761],{"name":58,"role":34,"phone":59,"phoneExt":23,"email":60},{"facility":763,"status":44,"city":764,"state":23,"zip":765,"country":735,"countryCode":736,"cosmosGeoPoint":766,"geoPoint":770,"contacts":771},"WISPer Site in Madrid, Spain 2","Madrid","28050",{"type":51,"coordinates":767},[768,769],-3.70256,40.4165,{"lat":769,"lon":768},[772],{"name":58,"role":34,"phone":59,"phoneExt":23,"email":60},{"facility":774,"status":44,"city":764,"state":23,"zip":775,"country":735,"countryCode":736,"cosmosGeoPoint":776,"geoPoint":778,"contacts":779},"WISPer Site in Madrid, Spain","28223",{"type":51,"coordinates":777},[768,769],{"lat":769,"lon":768},[780],{"name":58,"role":34,"phone":59,"phoneExt":23,"email":60},{"facility":782,"status":44,"city":783,"state":23,"zip":784,"country":735,"countryCode":736,"cosmosGeoPoint":785,"geoPoint":789,"contacts":790},"WISPer Site in Santander, Spain","Santander","39008",{"type":51,"coordinates":786},[787,788],-3.80493,43.46589,{"lat":788,"lon":787},[791],{"name":58,"role":34,"phone":59,"phoneExt":23,"email":60},{"facility":793,"status":44,"city":45,"state":23,"zip":794,"country":795,"countryCode":796,"cosmosGeoPoint":797,"geoPoint":801,"contacts":802},"WISPer Site in Birmingham, UK","B15 2GW","United Kingdom","UK",{"type":51,"coordinates":798},[799,800],-1.89983,52.48142,{"lat":800,"lon":799},[803],{"name":58,"role":34,"phone":59,"phoneExt":23,"email":60},{"facility":805,"status":44,"city":806,"state":23,"zip":807,"country":795,"countryCode":796,"cosmosGeoPoint":808,"geoPoint":812,"contacts":813},"WISPer Site in Cambridge, UK","Cambridge","CB2 0BB",{"type":51,"coordinates":809},[810,811],0.11667,52.2,{"lat":811,"lon":810},[814],{"name":58,"role":34,"phone":59,"phoneExt":23,"email":60},{"facility":816,"status":44,"city":817,"state":23,"zip":818,"country":795,"countryCode":796,"cosmosGeoPoint":819,"geoPoint":823,"contacts":824},"WISPer Site in Edinburgh, UK","Edinburgh","EH16 4SA",{"type":51,"coordinates":820},[821,822],-3.19648,55.95206,{"lat":822,"lon":821},[825],{"name":58,"role":34,"phone":59,"phoneExt":23,"email":60},{"facility":827,"status":44,"city":828,"state":23,"zip":829,"country":795,"countryCode":796,"cosmosGeoPoint":830,"geoPoint":834,"contacts":835},"WISPer Site in Oxford, UK","Oxford","OX3 7LE",{"type":51,"coordinates":831},[832,833],-1.25596,51.75222,{"lat":833,"lon":832},[836],{"name":58,"role":34,"phone":59,"phoneExt":23,"email":60},{"type":838,"investigatorFullName":23,"investigatorTitle":23,"investigatorAffiliation":23,"oldNameTitle":23,"oldOrganization":23},"SPONSOR","100590468",false,"NCT06967805","WISPer: Evaluation of MTX-463 in Participants With Idiopathic Pulmonary Fibrosis (IPF)","A Phase 2 Randomized, Double-blind, Placebo-controlled Study of the Safety and Efficacy of MTX-463 in Participants With Idiopathic Pulmonary Fibrosis (IPF)","Inclusion Criteria:\n\n* Participants with IPF of any gender ≥ 40 years of age at time of signing the informed consent.\n* Able to understand the study and provide signed, written informed consent.\n* Able to read and understand the language of the informed consent and other study-related materials.\n* Meet the American Thoracic Society, European Respiratory Society, Japanese Respiratory Society, and Latin American Thoracic Association (ATS\u002FERS\u002FJRS\u002FALAT) 2019 criteria for the diagnosis of IPF; Diagnosed with IPF within 7 years of screening.\n* If a participant is on treatment with pirfenidone, nintedanib, or nerandomilast, the dose of the medication must be stable for ≥ 90 days prior to Screening with plans to maintain the same dose throughout the study. Use of any of these 3 agents in combination with each other is not permitted.\n* If a participant was on treatment with pirfenidone, nintedanib, or nerandomilast, and the agent has been discontinued, this must have occurred ≥ 30 days prior to Screening. At Screening, there must also be no plan to start either of these medications for the duration of the study. Participants newly diagnosed with IPF who, in the judgment of the treating physician, are considered in need of treatment with nintedanib, pirfenidone, or nerandomilast should not defer standard of care treatment and should be excluded from the study.\n* FVC of ≥ 45 percent predicted (pp) at screening.\n* DLCO of ≥ 25pp at screening.\n* Willing and able to complete all protocol required study visits and procedures.\n* Female participants of childbearing potential must have a negative serum pregnancy test at Screening.\n* Participants with reproductive potential must agree to use and follow medically approved highly effective methods of contraception during treatment and until 5 half-lives or 125 days after the last dose of study drug, whichever is longer.\n* Male participants with female partners of childbearing potential must use condoms during the treatment and until 5 half-lives or 125 days after the last dose of study drug, whichever is longer.\n\nExclusion Criteria:\n\n* Acute exacerbation of IPF within 6 months of Screening or during the Screening Period.\n* Forced expiratory volume in 1 second (FEV1)\u002FFVC ratio of \\\u003C0.7 at Screening.\n* Requirement for continuous supplemental oxygen. Intermittent supplemental oxygen use (e.g., during exercise or sleep) is permitted.\n* Expected to receive a lung transplant within the study duration.\n* Current active bacterial infection or use of antibiotics for suspected lung infection in the 30 days prior to Screening.\n* Planned surgery within the study duration.\n* Clinically significant pulmonary hypertension.\n* Use of immunosuppressive therapy (excluding corticosteroids). If previously on such agents, they should have been discontinued for at least 5 half-lives or 90 days, whichever is longer, prior to Screening.\n* Use of systemic corticosteroids (prednisone or equivalent) at a dose \\> 10 mg once daily within 30 days of Screening.\n* Currently smoking or vaping.\n* Current known malignancy, or history of cancer, or lymphoproliferative disorder other than non-melanomatous skin cancers, within 2 years of Screening.\n* Current infection with hepatitis B, hepatitis C, or human immunodeficiency virus (HIV).\n* Currently pregnant, breast feeding, or planning to conceive for the length of the study.\n* History of severe depression, psychosis, or suicidal ideation, as determined by the Investigator, within 2 years of Screening.\n* Any clinically significant disease or laboratory abnormality detected at Screening that might interfere with a participant's ability to complete the study, on-study evaluations, or participant safety.\n* Aspartate aminotransferase (AST) or alanine aminotransferase (ALT) \\> 2× upper limit of normal (ULN) at Screening.\n* Presence of interstitial lung disease due to any cause other than IPF, clinically significant cardiovascular disease, or any other concurrent active medical condition determined by the Investigator to interfere with the participant's ability to complete the trial.\n* Known allergy to MTX-463 or any of its excipients, or a history of a prior allergic reaction to a monoclonal antibody therapeutic.\n* Any prior use of MTX-463 or other therapy targeting WISP1.\n* Any other concurrent experimental agent or an active part of any other clinical study, unless they have stopped taking the investigational product at least 5 half-lives or 30 days before Screening, whichever is longer.","ALL","40 Years",{"count":848,"type":849},164,"ESTIMATED","INTERVENTIONAL",[852],"PHASE2","A Phase 2a, Randomized, Double-blind, Placebo-Controlled Study of the Safety and Efficacy of MTX-463 in Participants with Idiopathic Pulmonary Fibrosis (IPF)",[855],"Idiopathic Pulmonary Fibrosis",[857,9,858,855,859,860,861,862,863,864],"MTX-463-I201","IPF","Adult","Fibrosis","Monoclonal Antibody","MAB","FVC","WISPer","2026-06-10",{"date":867,"type":868},"2026-06-12","ACTUAL",{"date":870,"type":868},"2025-05-05",{"date":872,"type":849},"2027-08",{"name":5,"class":6},69]