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Kingdom","UK",{"type":71,"coordinates":3464},[3465,3466],0.11667,52.2,{"lat":3466,"lon":3465},[3469],{"name":78,"role":58,"phone":3470,"phoneExt":34,"email":34},"+441223805000",{"facility":3472,"status":64,"city":3473,"state":3474,"zip":3475,"country":3461,"countryCode":3462,"cosmosGeoPoint":3476,"geoPoint":3480,"contacts":3481},"Mount Vernon Hospital ( Site 0921)","Northwood","Hillingdon","HA6 2RN",{"type":71,"coordinates":3477},[3478,3479],-0.42454,51.61162,{"lat":3479,"lon":3478},[3482],{"name":78,"role":58,"phone":3483,"phoneExt":34,"email":34},"0203 826 2020",{"facility":3485,"status":64,"city":3486,"state":3487,"zip":3488,"country":3461,"countryCode":3462,"cosmosGeoPoint":3489,"geoPoint":3493,"contacts":3494},"Royal Marsden Hospital (Sutton) ( Site 0922)","Sutton","London, City of","SM2 5PT",{"type":71,"coordinates":3490},[3491,3492],-0.2,51.35,{"lat":3492,"lon":3491},[3495],{"name":78,"role":58,"phone":3496,"phoneExt":34,"email":34},"+4402087224191",{"facility":3498,"status":64,"city":3499,"state":3461,"zip":3500,"country":3461,"countryCode":3462,"cosmosGeoPoint":34,"geoPoint":34,"contacts":3501},"Torbay Hospital ( Site 0918)","Devon","TQ2 7AA",[3502],{"name":78,"role":58,"phone":3503,"phoneExt":34,"email":34},"+441803656615",{"type":3505,"investigatorFullName":34,"investigatorTitle":34,"investigatorAffiliation":34,"oldNameTitle":34,"oldOrganization":34},"SPONSOR",[3507],{"name":3508,"class":6},"Daiichi Sankyo","100587234",false,"NCT06925737","A Clinical Study of Ifinatamab Deruxtecan (I-DXd) in People With Metastatic Prostate Cancer (MK-2400-001)","A Phase 3, Open-label Study of Ifinatamab Deruxtecan Versus Docetaxel in Participants With Metastatic Castration-Resistant Prostate Cancer (mCRPC) (IDeate-Prostate01)","Inclusion Criteria:\n\nThe main inclusion criteria include but are not limited to the following:\n\n* Has histologically- or cytologically-confirmed adenocarcinoma of the prostate without small cell histology\n* Has prostate cancer progression while on androgen deprivation therapy (ADT) (or post bilateral orchiectomy) within 6 months prior to Screening\n* Has current evidence of distant metastatic disease (M1 disease) documented by either bone lesions on bone scan and\u002For soft tissue disease by computed tomography (CT)\u002Fmagnetic resonance imaging (MRI)\n* Has received prior treatment with 1 or 2 androgen receptor pathway inhibitors (ARPIs) and progressed during or after at least 8 weeks of treatment\n* Has provided tumor tissue from a core or excisional biopsy from soft tissue not previously irradiated and obtained after disease progression on the most recent prior therapy\n* Has recovered from adverse events (AEs) due to previous anticancer therapies\n\nExclusion Criteria:\n\nThe main exclusion criteria include but are not limited to the following:\n\n* Is unable to swallow tablets\u002Fcapsules\n* Has any of the following indicators of interstitial lung disease (ILD)\u002Fpneumonitis:\n\n  1. Has any history of ILD\u002Fpneumonitis that required steroid use, except for a history of radiation pneumonitis that did not require steroids\n  2. Has current ILD\u002Fpneumonitis\n  3. Has a clinical or radiographic suspicion of ILD for which the diagnosis of ILD cannot be ruled out\n* Has clinically severe pulmonary compromise resulting from intercurrent pulmonary illnesses\n* Has uncontrolled or significant cardiovascular disease\n* Has received prior treatment with a taxane-based chemotherapy agent for metastatic castration-resistant prostate cancer (mCRPC)\n* Has had prior discontinuation of an antibody drug conjugate (ADC) that consists of an exatecan derivative (eg, trastuzumab deruxtecan) due to treatment-related toxicities\n* Has a \"superscan\" bone scan","MALE","18 Years",{"count":3518,"type":3519},1440,"ESTIMATED","INTERVENTIONAL",[3522],"PHASE3","Researchers are looking for new ways to treat metastatic castration-resistant prostate cancer (mCRPC). Researchers have designed a study medicine called ifinatamab deruxtecan (also called I-DXd or MK-2400) to treat mCRPC. The goal of this study is to learn if people who receive I-DXd live longer overall and live longer without the cancer growing or spreading than people who receive chemotherapy.",[3525,3526],"Prostate Cancer","Prostatic Neoplasms","2026-06-26",{"date":3529,"type":3530},"2026-06-29","ACTUAL",{"date":3532,"type":3530},"2025-05-13",{"date":3534,"type":3519},"2031-01-06",{"name":5,"class":6},290]