The GZPT master protocol will support two independent studies, J2A-MC-GZT1 and J2A-MC-GZT2. Each study will see how well and safely orforglipron works in people with obesity or overweight who have osteoarthritis (OA) of the knee with pain. Participation in the study will last about 74 weeks.
Have a body mass index (BMI) of 27 kilograms per square meter (kg/m2) or higher at screening
Have tried at least once to lose weight through diet but were unsuccessful
Be over 50 years old
Have morning knee stiffness that lasts about 30 minutes
Have gained or lost more than 11 pounds within 90 days prior to screening
Have had a surgery for obesity or plan to have one in the next 18 months
Have an active knee infection
Have type 1 diabetes, type 2 diabetes, or any other type of diabetes