[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100523825":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":31,"centralContacts":35,"locations":41,"responsibleParty":419,"collaborators":24,"id":421,"slug":24,"hasResults":422,"nctId":423,"briefTitle":424,"officialTitle":425,"acronym":24,"eligibilityCriteria":426,"healthyVolunteers":422,"sex":427,"minAge":428,"maxAge":429,"enrollmentInfo":430,"targetDuration":24,"studyType":433,"phases":434,"briefSummary":436,"conditions":437,"keywords":439,"overallStatus":44,"whyStopped":24,"lastUpdateSubmitDate":441,"lastUpdatePostDateStruct":442,"startDateStruct":445,"completionDateStruct":447,"leadSponsor":449,"locationsCount":450},{"fullName":5,"class":6},"AbbVie","INDUSTRY",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Risankizumab","EXPERIMENTAL","Participants will receive risankizumab for 24 weeks, in Period 1. Participants who respond to the study treatment received in Period 1, will continue to receive the same treatment in Period 2 for another 100 weeks. There will be a 140 day safety follow up after the treatment period.",[13],"Drug: Risankizumab",{"label":15,"type":10,"description":16,"interventionNames":17},"Adalimumab","Participants will receive adalimumab for 24 weeks, in Period 1. Participants who respond to the study treatment received in Period 1, will continue to receive the same treatment in Period 2 for another 100 weeks. There will be a 70 day safety follow up after the treatment period.",[18],"Drug: Adalimumab",[20,25],{"type":21,"name":15,"description":22,"armGroupLabels":23,"otherNames":24},"DRUG","SC Injection",[15],null,{"type":21,"name":9,"description":26,"armGroupLabels":27,"otherNames":28},"Subcutaneous (SC) Injection",[9],[29,30],"ABBV-066","Skyrizi",[32],{"name":33,"affiliation":5,"role":34},"ABBVIE INC.","STUDY_DIRECTOR",[36],{"name":37,"role":38,"phone":39,"phoneExt":24,"email":40},"ABBVIE CALL CENTER","CONTACT","844-663-3742","abbvieclinicaltrials@abbvie.com",[42,60,73,86,99,109,122,134,146,159,169,182,194,206,216,226,238,248,263,275,284,296,306,316,328,338,348,358,368,380,389,401,410],{"facility":43,"status":44,"city":45,"state":46,"zip":47,"country":48,"countryCode":49,"cosmosGeoPoint":50,"geoPoint":55,"contacts":56},"Arkansas Children's Hospital \u002FID# 258776","RECRUITING","Little Rock","Arkansas","72202","United 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259067","Indianapolis","Indiana","46202",{"type":51,"coordinates":105},[106,107],-86.15804,39.76838,{"lat":107,"lon":106},{"facility":110,"status":44,"city":111,"state":112,"zip":113,"country":48,"countryCode":49,"cosmosGeoPoint":114,"geoPoint":118,"contacts":119},"M Health Fairview University of Minnesota Medical Center - West Bank \u002FID# 260111","Minneapolis","Minnesota","55454",{"type":51,"coordinates":115},[116,117],-93.26384,44.97997,{"lat":117,"lon":116},[120],{"name":58,"role":38,"phone":24,"phoneExt":24,"email":121},"rheum-research@umn.edu",{"facility":123,"status":44,"city":124,"state":124,"zip":125,"country":48,"countryCode":49,"cosmosGeoPoint":126,"geoPoint":130,"contacts":131},"Columbia University Medical Center \u002FID# 262587","New 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Carolina","27514",{"type":51,"coordinates":152},[153,154],-79.05584,35.9132,{"lat":154,"lon":153},[157],{"name":58,"role":38,"phone":158,"phoneExt":24,"email":24},"919-504-6650",{"facility":160,"status":44,"city":161,"state":162,"zip":163,"country":48,"countryCode":49,"cosmosGeoPoint":164,"geoPoint":168,"contacts":24},"MetroHealth Medical Center \u002FID# 262377","Cleveland","Ohio","44109",{"type":51,"coordinates":165},[166,167],-81.69541,41.4995,{"lat":167,"lon":166},{"facility":170,"status":44,"city":171,"state":172,"zip":173,"country":48,"countryCode":49,"cosmosGeoPoint":174,"geoPoint":178,"contacts":179},"Child Neurology Consultants of Austin \u002FID# 260562","Austin","Texas","78757-7571",{"type":51,"coordinates":175},[176,177],-97.74306,30.26715,{"lat":177,"lon":176},[180],{"name":58,"role":38,"phone":181,"phoneExt":24,"email":24},"512-494-4000",{"facility":183,"status":44,"city":184,"state":185,"zip":186,"country":187,"countryCode":188,"cosmosGeoPoint":189,"geoPoint":193,"contacts":24},"Monash Health - Monash Medical Centre - Clayton \u002FID# 260255","Clayton","Victoria","3168","Australia","AU",{"type":51,"coordinates":190},[191,192],145.11667,-37.91667,{"lat":192,"lon":191},{"facility":195,"status":44,"city":196,"state":197,"zip":198,"country":199,"countryCode":200,"cosmosGeoPoint":201,"geoPoint":205,"contacts":24},"Alberta Children's Hospital \u002FID# 257880","Calgary","Alberta","T3B 6A8","Canada","CA",{"type":51,"coordinates":202},[203,204],-114.08529,51.05011,{"lat":204,"lon":203},{"facility":207,"status":44,"city":208,"state":209,"zip":210,"country":199,"countryCode":200,"cosmosGeoPoint":211,"geoPoint":215,"contacts":24},"British Columbia Children and Women's Hospital and Health Centre \u002FID# 257884","Vancouver","British Columbia","V6H 3N1",{"type":51,"coordinates":212},[213,214],-123.11934,49.24966,{"lat":214,"lon":213},{"facility":217,"status":44,"city":218,"state":219,"zip":220,"country":199,"countryCode":200,"cosmosGeoPoint":221,"geoPoint":225,"contacts":24},"Hospital for Sick Children \u002FID# 257879","Toronto","Ontario","M5G 1X8",{"type":51,"coordinates":222},[223,224],-79.39864,43.70643,{"lat":224,"lon":223},{"facility":227,"status":44,"city":228,"state":229,"zip":230,"country":231,"countryCode":232,"cosmosGeoPoint":233,"geoPoint":237,"contacts":24},"CHU Bordeaux - Hopital Pellegrin \u002FID# 258729","Bordeaux","New 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Berlin - Buch \u002FID# 268803","Berlin","13125",{"type":51,"coordinates":268},[269,270],13.41053,52.52437,{"lat":270,"lon":269},[273],{"name":58,"role":38,"phone":24,"phoneExt":24,"email":274},"kinderklinik.berlin-buch@helios-gesundheit.de",{"facility":276,"status":44,"city":277,"state":24,"zip":278,"country":253,"countryCode":254,"cosmosGeoPoint":279,"geoPoint":283,"contacts":24},"Hamburger Zentrum fuer Kinder- und Jugendrheumatologie \u002FID# 259104","Hamburg","22081",{"type":51,"coordinates":280},[281,282],9.99302,53.55073,{"lat":282,"lon":281},{"facility":285,"status":44,"city":286,"state":287,"zip":288,"country":289,"countryCode":290,"cosmosGeoPoint":291,"geoPoint":295,"contacts":24},"Azienda Ospedaliero Universitaria Meyer \u002FID# 258587","Florence","Firenze","50139","Italy","IT",{"type":51,"coordinates":292},[293,294],11.24626,43.77925,{"lat":294,"lon":293},{"facility":297,"status":44,"city":298,"state":299,"zip":300,"country":289,"countryCode":290,"cosmosGeoPoint":301,"geoPoint":305,"contacts":24},"ASST Centro Specialistico Ortopedico Traumatologico Gaetano Pini-CTO \u002FID# 276753","Milan","Milano","20122",{"type":51,"coordinates":302},[303,304],9.18951,45.46427,{"lat":304,"lon":303},{"facility":307,"status":44,"city":308,"state":309,"zip":310,"country":289,"countryCode":290,"cosmosGeoPoint":311,"geoPoint":315,"contacts":24},"Ospedale Pediatrico Bambino Gesù \u002FID# 258869","Rome","Roma","00165",{"type":51,"coordinates":312},[313,314],12.51133,41.89193,{"lat":314,"lon":313},{"facility":317,"status":44,"city":318,"state":319,"zip":320,"country":321,"countryCode":322,"cosmosGeoPoint":323,"geoPoint":327,"contacts":24},"Malopolskie Badania Kliniczne \u002FID# 258777","Cracow","Lesser Poland Voivodeship","30-002","Poland","PL",{"type":51,"coordinates":324},[325,326],19.93658,50.06143,{"lat":326,"lon":325},{"facility":329,"status":44,"city":330,"state":331,"zip":332,"country":321,"countryCode":322,"cosmosGeoPoint":333,"geoPoint":337,"contacts":24},"Uniwersytecki Szpital Dzieciecy w Lublinie \u002FID# 258781","Lublin","Lublin Voivodeship","20-093",{"type":51,"coordinates":334},[335,336],22.57009,51.25058,{"lat":336,"lon":335},{"facility":339,"status":44,"city":340,"state":341,"zip":342,"country":321,"countryCode":322,"cosmosGeoPoint":343,"geoPoint":347,"contacts":24},"Narodowy Instytut Geriatrii, Reumatologii I Rehabilitacji \u002FID# 277050","Warsaw","Masovian Voivodeship","02-637",{"type":51,"coordinates":344},[345,346],21.01178,52.22977,{"lat":346,"lon":345},{"facility":349,"status":44,"city":350,"state":351,"zip":352,"country":321,"countryCode":322,"cosmosGeoPoint":353,"geoPoint":357,"contacts":24},"Centrum Zdrowia Dziecka i Rodziny im Jana Pawla II w Sosnowcu \u002FID# 277058","Sosnowiec","Silesian Voivodeship","41-200",{"type":51,"coordinates":354},[355,356],19.10385,50.28682,{"lat":356,"lon":355},{"facility":359,"status":44,"city":360,"state":361,"zip":362,"country":321,"countryCode":322,"cosmosGeoPoint":363,"geoPoint":367,"contacts":24},"SPZOZ Centralny Szpital Kliniczny Uniwersytetu Medycznego w Lodzi \u002FID# 258785","Lodz","Łódź Voivodeship","91-738",{"type":51,"coordinates":364},[365,366],19.47395,51.77058,{"lat":366,"lon":365},{"facility":369,"status":44,"city":370,"state":371,"zip":372,"country":373,"countryCode":374,"cosmosGeoPoint":375,"geoPoint":379,"contacts":24},"Hospital Sant Joan de Deu \u002FID# 257568","Esplugues de Llobregat","Barcelona","08950","Spain","ES",{"type":51,"coordinates":376},[377,378],2.08809,41.37732,{"lat":378,"lon":377},{"facility":381,"status":44,"city":382,"state":24,"zip":383,"country":373,"countryCode":374,"cosmosGeoPoint":384,"geoPoint":388,"contacts":24},"Hospital Universitario y Politecnico La Fe \u002FID# 257567","Valencia","46026",{"type":51,"coordinates":385},[386,387],-0.37966,39.47391,{"lat":387,"lon":386},{"facility":390,"status":44,"city":391,"state":392,"zip":393,"country":394,"countryCode":395,"cosmosGeoPoint":396,"geoPoint":400,"contacts":24},"Sheffield Children's Hospital NHS Foundation Trust \u002FID# 258848","Sheffield","England","S10 2TH","United Kingdom","UK",{"type":51,"coordinates":397},[398,399],-1.4659,53.38297,{"lat":399,"lon":398},{"facility":402,"status":44,"city":403,"state":24,"zip":404,"country":394,"countryCode":395,"cosmosGeoPoint":405,"geoPoint":409,"contacts":24},"University Hospitals Bristol and Weston NHS Foundation Trust \u002FID# 258847","Bristol","BS2 8BJ",{"type":51,"coordinates":406},[407,408],-2.59665,51.45523,{"lat":408,"lon":407},{"facility":411,"status":44,"city":412,"state":24,"zip":413,"country":394,"countryCode":395,"cosmosGeoPoint":414,"geoPoint":418,"contacts":24},"Alder Hey Children's NHS Foundation Trust \u002FID# 262770","Liverpool","L12 2AP",{"type":51,"coordinates":415},[416,417],-2.97794,53.41058,{"lat":417,"lon":416},{"type":420,"investigatorFullName":24,"investigatorTitle":24,"investigatorAffiliation":24,"oldNameTitle":24,"oldOrganization":24},"SPONSOR","100523825",false,"NCT06100744","A Study to Assess Adverse Events, Change in Disease Activity, and How the Drug Moves Through the Body in Children With Juvenile Psoriatic Arthritis (jPsA) Receiving Subcutaneously Injected Risankizumab or Adalimumab","Open-label, Randomized, Assessor-blinded, Efficacy, Safety, Tolerability, and Pharmacokinetics Study of Subcutaneous Risankizumab With an Adalimumab Reference Arm in Children With Active Juvenile Psoriatic Arthritis","Inclusion Criteria:\n\n* Diagnosis of juvenile psoriatic arthritis (jPsA) according to International League of Associations for Rheumatology criteria for at least 3 months prior to screening.\n* Active Disease in \\>= 3 joints at screening and at Baseline (swelling not due to deformity, or limitation of motion with pain, tenderness, or both) are eligible for inclusion in the study.\n* Have had an inadequate response (lack of efficacy after minimum 2-month duration of therapy at maximally tolerated dose), or intolerance to previous or current treatment with at least 1 of the following conventional synthetic disease-modifying antirheumatic drug (csDMARDs): methotrexate (MTX), sulfasalazine, leflunomide, or hydroxychloroquine.\n\nExclusion Criteria:\n\n* Have any other autoimmune disease, rheumatic disease (including systemic Juvenile idiopathic arthritis \\[JIA\\], rheumatoid factor-positive or rheumatoid factor-negative polyarticular JIA, extended oligoarticular JIA, persistent oligoarticular JIA, enthesitis-related arthritis, and undifferentiated JIA), or overlap syndrome.\n* Prior inadequate response to treatments in the anti-TNF or IL-23 inhibitor classes.","ALL","5 Years","17 Years",{"count":431,"type":432},40,"ESTIMATED","INTERVENTIONAL",[435],"PHASE3","Psoriatic arthritis (PsA) is a type of arthritis that happens when the body's immune system attacks healthy cells and tissues causing joint pain, stiffness, and swelling. Symptoms can get worse and go away for periods of time. PsA that begins before a patient's 16th birthday is called juvenile PsA (jPsA).This study will evaluate how safe risankizumab is for the treatment of psoriatic arthritis and to assess change in disease symptoms.\n\nRisankizumab is being studied for the treatment of jPsA and adalimumab is approved for the treatment of jPsA. Participants are placed in 1 of 2 groups, called treatment arms. Each group receives a different treatment. There is a 1 in 4 chance that participants will be assigned to receive adalimumab. Approximately 40 juvenile participants with jPsA will be enrolled at approximately 30 sites worldwide.\n\nParticipants will receive risankizumab and adalimumab as subcutaneous (SC) injections based on body weight. At the start of Period 1, participants are randomized to receive risankizumab or adalimumab for 24 weeks. Participants who respond to the study treatment received in Period 1, will continue to receive the same treatment in Period 2 for another 100 weeks. Those with worsening jPsA symptoms in Period 2 will be withdrawn from the study. Participants who receive adalimumab are followed for safety for 70 days after the last study treatment. Participants who receive risankizumab are followed for 140 days after the last study treatment.\n\nThere may be higher treatment burden for participants in this trial compared to their standard of care (due to study procedures). Participants will attend regular visits during the study at a hospital or clinic. The effect of the treatment will be checked by medical assessments, blood tests, checking for side effects and completing questionnaires.",[438],"Juvenile Psoriatic Arthritis",[438,440,9,29,15],"Psoriatic Arthritis","2026-06-29",{"date":443,"type":444},"2026-06-30","ACTUAL",{"date":446,"type":444},"2024-07-08",{"date":448,"type":432},"2028-10",{"name":5,"class":6},33]