This study aims at investigating if adjunctive buprenorphine at low dose to treatment as usual is effective in reducing severe suicidal ideas in major depressive episode, and at determining the most effective dose.
The patient has been correctly informed.
The patient must have given his/her informed and signed the consent form.
The patient must be insured or beneficiary of a health insurance plan.
The patient is at least 18 years old and 65 years old at the most.
The patient is participating in another interventional trial;
The patient is in an exclusion period determined by a previous study;
The patient is under judicial protection, or is an adult under guardianship;
The patient is under compulsory admission;