Bleeding Reduction in Acute and Chronic Kidney Patients Having Surgery (BRACKETS) Pilot Trial
Trial statusRecruiting
Trial phasePhase 3
Trial typeInterventional
Biological sexAll
Age18+
SponsorHamilton Health Sciences Corporation
About this trial
The BRACKETS pilot study is a multicentre, prospective, randomized controlled trial of prophylactic preoperative tranexamic acid (TXA) versus placebo and, using a partial factorial design, of prophylactic preoperative desmopressin versus placebo.
Eligibility criteria
Qualifiers
Planned noncardiac surgery (elective, urgent, or emergency surgery);
Expected to require at least an overnight hospital admission after surgery;
Age ≥18 years; and
Informed consent is obtained to participate in the BRACKETS-Pilot Trial.
Disqualifiers
Undergoing cardiac surgery;
Undergoing intracranial neurosurgery;
Undergoing surgery for creation or revision of arteriovenous fistula or graft for dialysis access;
Planned use of prophylactic systemic TXA or ϵ-aminocaproic acid;
Trial design
Treatments tested in this trial
- Desmopressin Injectable Solution
- Tranexamic Acid Injectable Product
- Placebo
Treatment groups
100 Participants
are divided into 4 treatment groupsSponsors and collaborators
Hamilton Health Sciences Corporation
Lead sponsor
Population Health Research Institute
Collaborator
Source ClinicalTrials.gov