[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100599536":3},{"organization":4,"armGroups":7,"interventions":23,"overallOfficials":46,"centralContacts":50,"locations":55,"responsibleParty":1331,"collaborators":1333,"id":1336,"slug":34,"hasResults":1337,"nctId":1338,"briefTitle":1339,"officialTitle":1340,"acronym":1341,"eligibilityCriteria":1342,"healthyVolunteers":1337,"sex":1343,"minAge":1344,"maxAge":34,"enrollmentInfo":1345,"targetDuration":34,"studyType":1348,"phases":1349,"briefSummary":1351,"conditions":1352,"keywords":1358,"overallStatus":105,"whyStopped":34,"lastUpdateSubmitDate":1369,"lastUpdatePostDateStruct":1370,"startDateStruct":1373,"completionDateStruct":1375,"leadSponsor":1377,"locationsCount":1378},{"fullName":5,"class":6},"Olema Pharmaceuticals, Inc.","INDUSTRY",[8,16],{"label":9,"type":10,"description":11,"interventionNames":12},"Palazestrant","EXPERIMENTAL","Participants will receive palazestrant, ribociclib and letrozole-matching placebo",[13,14,15],"Drug: Palazestrant","Drug: Letrozole-matching placebo","Drug: Ribociclib",{"label":17,"type":18,"description":19,"interventionNames":20},"Letrozole","ACTIVE_COMPARATOR","Participants will receive letrozole, ribociclib and palazestrant-matching placebo",[15,21,22],"Drug: Letrozole","Drug: Palazestrant matching-placebo",[24,30,35,39,42],{"type":25,"name":9,"description":26,"armGroupLabels":27,"otherNames":28},"DRUG","Participants will be treated with palazestrant 90 mg once daily on a 4-week (28-day) cycle.",[9],[29],"OP-1250",{"type":25,"name":31,"description":32,"armGroupLabels":33,"otherNames":34},"Letrozole-matching placebo","Participants will be treated with letrozole-matching placebo once daily on a 4-week (28 day) cycle",[9],null,{"type":25,"name":36,"description":37,"armGroupLabels":38,"otherNames":34},"Ribociclib","Participants will be treated with ribociclib 600 mg once daily on Days 1-21 of a 4-week (28 day) cycle.",[17,9],{"type":25,"name":17,"description":40,"armGroupLabels":41,"otherNames":34},"Participants will be treated with letrozole 2.5 mg once daily on a 4-week (28-day) cycle",[17],{"type":25,"name":43,"description":44,"armGroupLabels":45,"otherNames":34},"Palazestrant matching-placebo","Participants will be treated with palazestrant-matching placebo once daily on a 4-week (28-day) cycle",[17],[47],{"name":48,"affiliation":5,"role":49},"Medical Director, MD","STUDY_DIRECTOR",[51],{"name":5,"role":52,"phone":53,"phoneExt":34,"email":54},"CONTACT","415-651-7206","OPERA-02@olema.com",[56,70,79,87,95,104,113,122,131,140,149,158,166,175,184,193,202,211,220,228,237,246,254,263,271,280,288,296,304,313,321,329,337,347,356,364,373,381,392,400,409,418,427,435,443,452,463,474,482,491,500,509,520,530,539,548,556,564,575,584,592,601,610,619,627,636,647,658,667,673,681,690,695,700,711,720,731,740,749,758,766,774,783,789,800,808,812,821,830,839,848,857,868,877,886,897,906,911,920,929,940,949,959,968,977,986,995,1004,1014,1023,1032,1040,1048,1056,1064,1070,1075,1080,1086,1091,1101,1109,1114,1119,1127,1135,1143,1151,1156,1161,1166,1174,1183,1191,1199,1210,1219,1228,1233,1239,1244,1254,1262,1271,1280,1288,1299,1307,1313,1322],{"facility":57,"status":58,"city":59,"state":60,"zip":61,"country":62,"countryCode":63,"cosmosGeoPoint":64,"geoPoint":69,"contacts":34},"Clinical Trial Site","ACTIVE_NOT_RECRUITING","Hot Springs","Arkansas","71913","United States","US",{"type":65,"coordinates":66},"Point",[67,68],-93.05518,34.5037,{"lat":68,"lon":67},{"facility":57,"status":58,"city":71,"state":72,"zip":73,"country":62,"countryCode":63,"cosmosGeoPoint":74,"geoPoint":78,"contacts":34},"Beverly Hills","California","90211",{"type":65,"coordinates":75},[76,77],-118.40036,34.07362,{"lat":77,"lon":76},{"facility":57,"status":58,"city":80,"state":72,"zip":81,"country":62,"countryCode":63,"cosmosGeoPoint":82,"geoPoint":86,"contacts":34},"San Francisco","94115",{"type":65,"coordinates":83},[84,85],-122.41942,37.77493,{"lat":85,"lon":84},{"facility":57,"status":58,"city":88,"state":72,"zip":89,"country":62,"countryCode":63,"cosmosGeoPoint":90,"geoPoint":94,"contacts":34},"Santa Barbara","93105",{"type":65,"coordinates":91},[92,93],-119.69819,34.42083,{"lat":93,"lon":92},{"facility":57,"status":58,"city":96,"state":97,"zip":98,"country":62,"countryCode":63,"cosmosGeoPoint":99,"geoPoint":103,"contacts":34},"Aurora","Colorado","80045",{"type":65,"coordinates":100},[101,102],-104.83192,39.72943,{"lat":102,"lon":101},{"facility":57,"status":105,"city":106,"state":97,"zip":107,"country":62,"countryCode":63,"cosmosGeoPoint":108,"geoPoint":112,"contacts":34},"RECRUITING","Denver","80220",{"type":65,"coordinates":109},[110,111],-104.9847,39.73915,{"lat":111,"lon":110},{"facility":57,"status":58,"city":114,"state":115,"zip":116,"country":62,"countryCode":63,"cosmosGeoPoint":117,"geoPoint":121,"contacts":34},"New Haven","Connecticut","06511",{"type":65,"coordinates":118},[119,120],-72.92816,41.30815,{"lat":120,"lon":119},{"facility":57,"status":58,"city":123,"state":124,"zip":125,"country":62,"countryCode":63,"cosmosGeoPoint":126,"geoPoint":130,"contacts":34},"Tampa","Florida","33612",{"type":65,"coordinates":127},[128,129],-82.45843,27.94752,{"lat":129,"lon":128},{"facility":57,"status":105,"city":132,"state":133,"zip":134,"country":62,"countryCode":63,"cosmosGeoPoint":135,"geoPoint":139,"contacts":34},"Marietta","Georgia","30060",{"type":65,"coordinates":136},[137,138],-84.54993,33.9526,{"lat":138,"lon":137},{"facility":57,"status":58,"city":141,"state":142,"zip":143,"country":62,"countryCode":63,"cosmosGeoPoint":144,"geoPoint":148,"contacts":34},"Honolulu","Hawaii","96813",{"type":65,"coordinates":145},[146,147],-157.85833,21.30694,{"lat":147,"lon":146},{"facility":57,"status":105,"city":150,"state":151,"zip":152,"country":62,"countryCode":63,"cosmosGeoPoint":153,"geoPoint":157,"contacts":34},"Peoria","Illinois","61615",{"type":65,"coordinates":154},[155,156],-89.58899,40.69365,{"lat":156,"lon":155},{"facility":57,"status":58,"city":159,"state":151,"zip":160,"country":62,"countryCode":63,"cosmosGeoPoint":161,"geoPoint":165,"contacts":34},"Urbana","61801",{"type":65,"coordinates":162},[163,164],-88.20727,40.11059,{"lat":164,"lon":163},{"facility":57,"status":58,"city":167,"state":168,"zip":169,"country":62,"countryCode":63,"cosmosGeoPoint":170,"geoPoint":174,"contacts":34},"Ames","Iowa","50010",{"type":65,"coordinates":171},[172,173],-93.61994,42.03471,{"lat":173,"lon":172},{"facility":57,"status":105,"city":176,"state":177,"zip":178,"country":62,"countryCode":63,"cosmosGeoPoint":179,"geoPoint":183,"contacts":34},"Scarborough","Maine","04074",{"type":65,"coordinates":180},[181,182],-70.32172,43.57814,{"lat":182,"lon":181},{"facility":57,"status":105,"city":185,"state":186,"zip":187,"country":62,"countryCode":63,"cosmosGeoPoint":188,"geoPoint":192,"contacts":34},"Annapolis","Maryland","21401",{"type":65,"coordinates":189},[190,191],-76.49184,38.97859,{"lat":191,"lon":190},{"facility":57,"status":105,"city":194,"state":195,"zip":196,"country":62,"countryCode":63,"cosmosGeoPoint":197,"geoPoint":201,"contacts":34},"Minneapolis","Minnesota","55404",{"type":65,"coordinates":198},[199,200],-93.26384,44.97997,{"lat":200,"lon":199},{"facility":57,"status":105,"city":203,"state":204,"zip":205,"country":62,"countryCode":63,"cosmosGeoPoint":206,"geoPoint":210,"contacts":34},"Kansas City","Missouri","64132",{"type":65,"coordinates":207},[208,209],-94.57857,39.09973,{"lat":209,"lon":208},{"facility":57,"status":105,"city":212,"state":213,"zip":214,"country":62,"countryCode":63,"cosmosGeoPoint":215,"geoPoint":219,"contacts":34},"Santa Fe","New Mexico","87505",{"type":65,"coordinates":216},[217,218],-105.9378,35.68698,{"lat":218,"lon":217},{"facility":57,"status":58,"city":221,"state":221,"zip":222,"country":62,"countryCode":63,"cosmosGeoPoint":223,"geoPoint":227,"contacts":34},"New York","10032",{"type":65,"coordinates":224},[225,226],-74.00597,40.71427,{"lat":226,"lon":225},{"facility":57,"status":58,"city":229,"state":230,"zip":231,"country":62,"countryCode":63,"cosmosGeoPoint":232,"geoPoint":236,"contacts":34},"Charlotte","North Carolina","28204",{"type":65,"coordinates":233},[234,235],-80.84313,35.22709,{"lat":235,"lon":234},{"facility":57,"status":105,"city":238,"state":239,"zip":240,"country":62,"countryCode":63,"cosmosGeoPoint":241,"geoPoint":245,"contacts":34},"Cincinnati","Ohio","45245",{"type":65,"coordinates":242},[243,244],-84.51439,39.12711,{"lat":244,"lon":243},{"facility":57,"status":105,"city":247,"state":239,"zip":248,"country":62,"countryCode":63,"cosmosGeoPoint":249,"geoPoint":253,"contacts":34},"Columbus","43219",{"type":65,"coordinates":250},[251,252],-82.99879,39.96118,{"lat":252,"lon":251},{"facility":57,"status":58,"city":255,"state":256,"zip":257,"country":62,"countryCode":63,"cosmosGeoPoint":258,"geoPoint":262,"contacts":34},"Horsham","Pennsylvania","19044",{"type":65,"coordinates":259},[260,261],-75.12851,40.17844,{"lat":261,"lon":260},{"facility":57,"status":105,"city":264,"state":256,"zip":265,"country":62,"countryCode":63,"cosmosGeoPoint":266,"geoPoint":270,"contacts":34},"Sayre","18840",{"type":65,"coordinates":267},[268,269],-76.5155,41.97896,{"lat":269,"lon":268},{"facility":57,"status":58,"city":272,"state":273,"zip":274,"country":62,"countryCode":63,"cosmosGeoPoint":275,"geoPoint":279,"contacts":34},"Bartlett","Tennessee","38133",{"type":65,"coordinates":276},[277,278],-89.87398,35.20453,{"lat":278,"lon":277},{"facility":57,"status":58,"city":281,"state":273,"zip":282,"country":62,"countryCode":63,"cosmosGeoPoint":283,"geoPoint":287,"contacts":34},"Knoxville","37909",{"type":65,"coordinates":284},[285,286],-83.92074,35.96064,{"lat":286,"lon":285},{"facility":57,"status":58,"city":289,"state":273,"zip":290,"country":62,"countryCode":63,"cosmosGeoPoint":291,"geoPoint":295,"contacts":34},"Mount Juliet","37122",{"type":65,"coordinates":292},[293,294],-86.51861,36.20005,{"lat":294,"lon":293},{"facility":57,"status":105,"city":297,"state":273,"zip":298,"country":62,"countryCode":63,"cosmosGeoPoint":299,"geoPoint":303,"contacts":34},"Tennessee City","37203",{"type":65,"coordinates":300},[301,302],-87.51474,36.09312,{"lat":302,"lon":301},{"facility":57,"status":105,"city":305,"state":306,"zip":307,"country":62,"countryCode":63,"cosmosGeoPoint":308,"geoPoint":312,"contacts":34},"Denton","Texas","76201",{"type":65,"coordinates":309},[310,311],-97.13307,33.21484,{"lat":311,"lon":310},{"facility":57,"status":105,"city":314,"state":306,"zip":315,"country":62,"countryCode":63,"cosmosGeoPoint":316,"geoPoint":320,"contacts":34},"El Paso","79902",{"type":65,"coordinates":317},[318,319],-106.48693,31.75872,{"lat":319,"lon":318},{"facility":57,"status":105,"city":322,"state":306,"zip":323,"country":62,"countryCode":63,"cosmosGeoPoint":324,"geoPoint":328,"contacts":34},"Houston","77024",{"type":65,"coordinates":325},[326,327],-95.36327,29.76328,{"lat":327,"lon":326},{"facility":57,"status":58,"city":330,"state":306,"zip":331,"country":62,"countryCode":63,"cosmosGeoPoint":332,"geoPoint":336,"contacts":34},"San Antonio","78229",{"type":65,"coordinates":333},[334,335],-98.49363,29.42412,{"lat":335,"lon":334},{"facility":57,"status":338,"city":339,"state":340,"zip":341,"country":62,"countryCode":63,"cosmosGeoPoint":342,"geoPoint":346,"contacts":34},"NOT_YET_RECRUITING","Salt Lake City","Utah","84106",{"type":65,"coordinates":343},[344,345],-111.89105,40.76078,{"lat":345,"lon":344},{"facility":57,"status":58,"city":348,"state":349,"zip":350,"country":62,"countryCode":63,"cosmosGeoPoint":351,"geoPoint":355,"contacts":34},"Fort Belvoir","Virginia","22060",{"type":65,"coordinates":352},[353,354],-77.14589,38.7119,{"lat":354,"lon":353},{"facility":57,"status":58,"city":357,"state":349,"zip":358,"country":62,"countryCode":63,"cosmosGeoPoint":359,"geoPoint":363,"contacts":34},"Norfolk","23502",{"type":65,"coordinates":360},[361,362],-76.28522,36.84681,{"lat":362,"lon":361},{"facility":57,"status":58,"city":365,"state":366,"zip":367,"country":62,"countryCode":63,"cosmosGeoPoint":368,"geoPoint":372,"contacts":34},"Olympia","Washington","98502",{"type":65,"coordinates":369},[370,371],-122.90169,47.04491,{"lat":371,"lon":370},{"facility":57,"status":58,"city":374,"state":366,"zip":375,"country":62,"countryCode":63,"cosmosGeoPoint":376,"geoPoint":380,"contacts":34},"Vancouver","98684",{"type":65,"coordinates":377},[378,379],-122.66149,45.63873,{"lat":379,"lon":378},{"facility":57,"status":105,"city":382,"state":383,"zip":384,"country":385,"countryCode":386,"cosmosGeoPoint":387,"geoPoint":391,"contacts":34},"Sydney","New South Wales","2109","Australia","AU",{"type":65,"coordinates":388},[389,390],151.20732,-33.86785,{"lat":390,"lon":389},{"facility":57,"status":105,"city":393,"state":383,"zip":394,"country":385,"countryCode":386,"cosmosGeoPoint":395,"geoPoint":399,"contacts":34},"Waratah","2298",{"type":65,"coordinates":396},[397,398],151.72647,-32.90667,{"lat":398,"lon":397},{"facility":57,"status":105,"city":401,"state":402,"zip":403,"country":385,"countryCode":386,"cosmosGeoPoint":404,"geoPoint":408,"contacts":34},"South Brisbane","Queensland","4101",{"type":65,"coordinates":405},[406,407],153.02049,-27.48034,{"lat":407,"lon":406},{"facility":57,"status":105,"city":410,"state":411,"zip":412,"country":385,"countryCode":386,"cosmosGeoPoint":413,"geoPoint":417,"contacts":34},"Adelaide","South Australia","5000",{"type":65,"coordinates":414},[415,416],138.59863,-34.92866,{"lat":416,"lon":415},{"facility":57,"status":105,"city":419,"state":420,"zip":421,"country":385,"countryCode":386,"cosmosGeoPoint":422,"geoPoint":426,"contacts":34},"Clayton","Victoria","3168",{"type":65,"coordinates":423},[424,425],145.11667,-37.91667,{"lat":425,"lon":424},{"facility":57,"status":105,"city":428,"state":420,"zip":429,"country":385,"countryCode":386,"cosmosGeoPoint":430,"geoPoint":434,"contacts":34},"Geelong","3220",{"type":65,"coordinates":431},[432,433],144.36069,-38.14711,{"lat":433,"lon":432},{"facility":57,"status":105,"city":436,"state":420,"zip":437,"country":385,"countryCode":386,"cosmosGeoPoint":438,"geoPoint":442,"contacts":34},"Heidelberg","03084",{"type":65,"coordinates":439},[440,441],145.06667,-37.75,{"lat":441,"lon":440},{"facility":57,"status":105,"city":444,"state":445,"zip":446,"country":385,"countryCode":386,"cosmosGeoPoint":447,"geoPoint":451,"contacts":34},"Nedlands","Western Australia","6009",{"type":65,"coordinates":448},[449,450],115.8073,-31.98184,{"lat":450,"lon":449},{"facility":57,"status":105,"city":453,"state":454,"zip":455,"country":456,"countryCode":457,"cosmosGeoPoint":458,"geoPoint":462,"contacts":34},"Linz","Upper Austria","4010","Austria","AT",{"type":65,"coordinates":459},[460,461],14.28611,48.30639,{"lat":461,"lon":460},{"facility":57,"status":58,"city":464,"state":465,"zip":466,"country":467,"countryCode":468,"cosmosGeoPoint":469,"geoPoint":473,"contacts":34},"Brussels","Brussels Capital","1090","Belgium","BE",{"type":65,"coordinates":470},[471,472],4.34878,50.85045,{"lat":472,"lon":471},{"facility":57,"status":58,"city":475,"state":465,"zip":476,"country":467,"countryCode":468,"cosmosGeoPoint":477,"geoPoint":481,"contacts":34},"Woluwe-Saint-Lambert","1200",{"type":65,"coordinates":478},[479,480],4.42912,50.84389,{"lat":480,"lon":479},{"facility":57,"status":58,"city":483,"state":484,"zip":485,"country":467,"countryCode":468,"cosmosGeoPoint":486,"geoPoint":490,"contacts":34},"Kortrijk","Flanders","8500",{"type":65,"coordinates":487},[488,489],3.26487,50.82803,{"lat":489,"lon":488},{"facility":57,"status":58,"city":492,"state":493,"zip":494,"country":467,"countryCode":468,"cosmosGeoPoint":495,"geoPoint":499,"contacts":34},"Liège","Liège Province","4000",{"type":65,"coordinates":496},[497,498],5.56749,50.63373,{"lat":498,"lon":497},{"facility":57,"status":105,"city":501,"state":502,"zip":503,"country":467,"countryCode":468,"cosmosGeoPoint":504,"geoPoint":508,"contacts":34},"Charleroi","Wallonia","6060",{"type":65,"coordinates":505},[506,507],4.44448,50.41136,{"lat":507,"lon":506},{"facility":57,"status":105,"city":510,"state":511,"zip":512,"country":513,"countryCode":514,"cosmosGeoPoint":515,"geoPoint":519,"contacts":34},"Toronto","Ontario","M2J 1V1","Canada","CA",{"type":65,"coordinates":516},[517,518],-79.39864,43.70643,{"lat":518,"lon":517},{"facility":57,"status":58,"city":521,"state":522,"zip":523,"country":524,"countryCode":34,"cosmosGeoPoint":525,"geoPoint":529,"contacts":34},"Hořovice","Central Bohemia","26831","Czechia",{"type":65,"coordinates":526},[527,528],13.90268,49.83597,{"lat":528,"lon":527},{"facility":57,"status":58,"city":531,"state":532,"zip":533,"country":524,"countryCode":34,"cosmosGeoPoint":534,"geoPoint":538,"contacts":34},"Liberec","Liberec Region","46001",{"type":65,"coordinates":535},[536,537],15.05619,50.76711,{"lat":537,"lon":536},{"facility":57,"status":58,"city":540,"state":541,"zip":542,"country":524,"countryCode":34,"cosmosGeoPoint":543,"geoPoint":547,"contacts":34},"Olomouc","Olomouc Region","77900",{"type":65,"coordinates":544},[545,546],17.25175,49.59552,{"lat":546,"lon":545},{"facility":57,"status":58,"city":549,"state":549,"zip":550,"country":524,"countryCode":34,"cosmosGeoPoint":551,"geoPoint":555,"contacts":34},"Prague","150 06",{"type":65,"coordinates":552},[553,554],14.42076,50.08804,{"lat":554,"lon":553},{"facility":57,"status":105,"city":557,"state":557,"zip":558,"country":524,"countryCode":34,"cosmosGeoPoint":559,"geoPoint":563,"contacts":34},"Zlín","762 75",{"type":65,"coordinates":560},[561,562],17.67065,49.22645,{"lat":562,"lon":561},{"facility":57,"status":105,"city":565,"state":566,"zip":567,"country":568,"countryCode":569,"cosmosGeoPoint":570,"geoPoint":574,"contacts":34},"Pierre-Bénite","Auvergne-Rhône-Alpes","69310","France","FR",{"type":65,"coordinates":571},[572,573],4.82424,45.70359,{"lat":573,"lon":572},{"facility":57,"status":58,"city":576,"state":577,"zip":578,"country":568,"countryCode":569,"cosmosGeoPoint":579,"geoPoint":583,"contacts":34},"Brest","Brittany Region","29609",{"type":65,"coordinates":580},[581,582],-4.48628,48.39029,{"lat":582,"lon":581},{"facility":57,"status":105,"city":585,"state":577,"zip":586,"country":568,"countryCode":569,"cosmosGeoPoint":587,"geoPoint":591,"contacts":34},"Plérin","22190",{"type":65,"coordinates":588},[589,590],-2.76975,48.53451,{"lat":590,"lon":589},{"facility":57,"status":58,"city":593,"state":594,"zip":595,"country":568,"countryCode":569,"cosmosGeoPoint":596,"geoPoint":600,"contacts":34},"Besançon","Doubs","25000",{"type":65,"coordinates":597},[598,599],6.01815,47.24878,{"lat":599,"lon":598},{"facility":57,"status":105,"city":602,"state":603,"zip":604,"country":568,"countryCode":569,"cosmosGeoPoint":605,"geoPoint":609,"contacts":34},"Montpellier","Hérault","34070",{"type":65,"coordinates":606},[607,608],3.87635,43.61093,{"lat":608,"lon":607},{"facility":57,"status":58,"city":611,"state":612,"zip":613,"country":568,"countryCode":569,"cosmosGeoPoint":614,"geoPoint":618,"contacts":34},"Toulouse","Occitanie","31059",{"type":65,"coordinates":615},[616,617],1.44367,43.60426,{"lat":617,"lon":616},{"facility":57,"status":105,"city":620,"state":34,"zip":621,"country":568,"countryCode":569,"cosmosGeoPoint":622,"geoPoint":626,"contacts":34},"Bobigny","93000",{"type":65,"coordinates":623},[624,625],2.45012,48.90982,{"lat":625,"lon":624},{"facility":57,"status":58,"city":628,"state":629,"zip":630,"country":568,"countryCode":569,"cosmosGeoPoint":631,"geoPoint":635,"contacts":34},"Villejuif","Île-de-France Region","94805",{"type":65,"coordinates":632},[633,634],2.35992,48.7939,{"lat":634,"lon":633},{"facility":57,"status":58,"city":637,"state":638,"zip":639,"country":640,"countryCode":641,"cosmosGeoPoint":642,"geoPoint":646,"contacts":34},"Torgau","Saxony","04860","Germany","DE",{"type":65,"coordinates":643},[644,645],12.99617,51.56016,{"lat":645,"lon":644},{"facility":57,"status":58,"city":648,"state":649,"zip":650,"country":651,"countryCode":652,"cosmosGeoPoint":653,"geoPoint":657,"contacts":34},"Pátrai","Achaia","26504","Greece","GR",{"type":65,"coordinates":654},[655,656],21.73508,38.2462,{"lat":656,"lon":655},{"facility":57,"status":58,"city":659,"state":660,"zip":661,"country":651,"countryCode":652,"cosmosGeoPoint":662,"geoPoint":666,"contacts":34},"Athens","Attica","11528",{"type":65,"coordinates":663},[664,665],23.72784,37.98376,{"lat":665,"lon":664},{"facility":57,"status":58,"city":659,"state":668,"zip":669,"country":651,"countryCode":652,"cosmosGeoPoint":670,"geoPoint":672,"contacts":34},"Pireas","18547",{"type":65,"coordinates":671},[664,665],{"lat":665,"lon":664},{"facility":57,"status":105,"city":674,"state":674,"zip":675,"country":651,"countryCode":652,"cosmosGeoPoint":676,"geoPoint":680,"contacts":34},"Thessaloniki","57001",{"type":65,"coordinates":677},[678,679],22.93493,40.64072,{"lat":679,"lon":678},{"facility":57,"status":58,"city":682,"state":682,"zip":683,"country":682,"countryCode":684,"cosmosGeoPoint":685,"geoPoint":689,"contacts":34},"Hong Kong","999077","HK",{"type":65,"coordinates":686},[687,688],114.17469,22.27832,{"lat":688,"lon":687},{"facility":57,"status":105,"city":682,"state":691,"zip":683,"country":682,"countryCode":684,"cosmosGeoPoint":692,"geoPoint":694,"contacts":34},"Kowloon",{"type":65,"coordinates":693},[687,688],{"lat":688,"lon":687},{"facility":57,"status":105,"city":682,"state":696,"zip":683,"country":682,"countryCode":684,"cosmosGeoPoint":697,"geoPoint":699,"contacts":34},"Pok Fu Lam",{"type":65,"coordinates":698},[687,688],{"lat":688,"lon":687},{"facility":57,"status":105,"city":701,"state":702,"zip":703,"country":704,"countryCode":705,"cosmosGeoPoint":706,"geoPoint":710,"contacts":34},"Kecskemét","Bács-Kiskun county","6000","Hungary","HU",{"type":65,"coordinates":707},[708,709],19.69128,46.90618,{"lat":709,"lon":708},{"facility":57,"status":105,"city":712,"state":713,"zip":714,"country":704,"countryCode":705,"cosmosGeoPoint":715,"geoPoint":719,"contacts":34},"Debrecen","Hajdú-Bihar","4032",{"type":65,"coordinates":716},[717,718],21.62444,47.53167,{"lat":718,"lon":717},{"facility":57,"status":58,"city":721,"state":722,"zip":723,"country":724,"countryCode":725,"cosmosGeoPoint":726,"geoPoint":730,"contacts":34},"Bologna","Emilia-Romagna","40138","Italy","IT",{"type":65,"coordinates":727},[728,729],11.33875,44.49381,{"lat":729,"lon":728},{"facility":57,"status":58,"city":732,"state":733,"zip":734,"country":724,"countryCode":725,"cosmosGeoPoint":735,"geoPoint":739,"contacts":34},"Rome","Lazio","168",{"type":65,"coordinates":736},[737,738],12.51133,41.89193,{"lat":738,"lon":737},{"facility":57,"status":105,"city":741,"state":742,"zip":743,"country":724,"countryCode":725,"cosmosGeoPoint":744,"geoPoint":748,"contacts":34},"Genoa","Liguria","16132",{"type":65,"coordinates":745},[746,747],8.94439,44.40478,{"lat":747,"lon":746},{"facility":57,"status":105,"city":750,"state":751,"zip":752,"country":724,"countryCode":725,"cosmosGeoPoint":753,"geoPoint":757,"contacts":34},"Bergamo","Lombardy","24127",{"type":65,"coordinates":754},[755,756],9.66721,45.69601,{"lat":756,"lon":755},{"facility":57,"status":58,"city":759,"state":751,"zip":760,"country":724,"countryCode":725,"cosmosGeoPoint":761,"geoPoint":765,"contacts":34},"Milan","20141",{"type":65,"coordinates":762},[763,764],9.18951,45.46427,{"lat":764,"lon":763},{"facility":57,"status":105,"city":759,"state":767,"zip":768,"country":724,"countryCode":725,"cosmosGeoPoint":769,"geoPoint":773,"contacts":34},"Milano","20132",{"type":65,"coordinates":770},[771,772],12.59836,42.78235,{"lat":772,"lon":771},{"facility":57,"status":58,"city":775,"state":776,"zip":777,"country":724,"countryCode":725,"cosmosGeoPoint":778,"geoPoint":782,"contacts":34},"Prato","Tuscany","59100",{"type":65,"coordinates":779},[780,781],11.09699,43.8805,{"lat":781,"lon":780},{"facility":57,"status":105,"city":759,"state":784,"zip":785,"country":724,"countryCode":725,"cosmosGeoPoint":786,"geoPoint":788,"contacts":34},"Varese","21100",{"type":65,"coordinates":787},[763,764],{"lat":764,"lon":763},{"facility":57,"status":105,"city":790,"state":791,"zip":792,"country":793,"countryCode":794,"cosmosGeoPoint":795,"geoPoint":799,"contacts":34},"Ipoh","Ipoh Perak","30450","Malaysia","MY",{"type":65,"coordinates":796},[797,798],101.0829,4.5841,{"lat":798,"lon":797},{"facility":57,"status":105,"city":801,"state":801,"zip":802,"country":793,"countryCode":794,"cosmosGeoPoint":803,"geoPoint":807,"contacts":34},"Kuala Lumpur","50586",{"type":65,"coordinates":804},[805,806],101.68653,3.1412,{"lat":806,"lon":805},{"facility":57,"status":105,"city":801,"state":801,"zip":777,"country":793,"countryCode":794,"cosmosGeoPoint":809,"geoPoint":811,"contacts":34},{"type":65,"coordinates":810},[805,806],{"lat":806,"lon":805},{"facility":57,"status":105,"city":813,"state":814,"zip":815,"country":793,"countryCode":794,"cosmosGeoPoint":816,"geoPoint":820,"contacts":34},"George Town","Pulau Pinang","10450",{"type":65,"coordinates":817},[818,819],100.33543,5.41123,{"lat":819,"lon":818},{"facility":57,"status":105,"city":822,"state":823,"zip":824,"country":793,"countryCode":794,"cosmosGeoPoint":825,"geoPoint":829,"contacts":34},"Kota Kinabalu","Sabah","88996",{"type":65,"coordinates":826},[827,828],116.0724,5.9749,{"lat":828,"lon":827},{"facility":57,"status":105,"city":831,"state":832,"zip":833,"country":793,"countryCode":794,"cosmosGeoPoint":834,"geoPoint":838,"contacts":34},"Kuching","Sarawak","93586",{"type":65,"coordinates":835},[836,837],110.33333,1.55,{"lat":837,"lon":836},{"facility":57,"status":105,"city":840,"state":841,"zip":842,"country":793,"countryCode":794,"cosmosGeoPoint":843,"geoPoint":847,"contacts":34},"Petaling Jaya","Selangor","46050",{"type":65,"coordinates":844},[845,846],101.60671,3.10726,{"lat":846,"lon":845},{"facility":57,"status":105,"city":849,"state":850,"zip":851,"country":793,"countryCode":794,"cosmosGeoPoint":852,"geoPoint":856,"contacts":34},"Putrajaya","Wilayah PE","62250",{"type":65,"coordinates":853},[854,855],101.69112,2.93527,{"lat":855,"lon":854},{"facility":57,"status":105,"city":858,"state":859,"zip":860,"country":861,"countryCode":862,"cosmosGeoPoint":863,"geoPoint":867,"contacts":34},"Apeldoorn","Gelderland","7334 DZ","Netherlands","NL",{"type":65,"coordinates":864},[865,866],5.96944,52.21,{"lat":866,"lon":865},{"facility":57,"status":58,"city":869,"state":870,"zip":871,"country":861,"countryCode":862,"cosmosGeoPoint":872,"geoPoint":876,"contacts":34},"Maastricht","Limberg","6202 AZ",{"type":65,"coordinates":873},[874,875],5.68889,50.84833,{"lat":875,"lon":874},{"facility":57,"status":58,"city":878,"state":879,"zip":880,"country":861,"countryCode":862,"cosmosGeoPoint":881,"geoPoint":885,"contacts":34},"Amsterdam","North Holland","1081 HV",{"type":65,"coordinates":882},[883,884],4.88969,52.37403,{"lat":884,"lon":883},{"facility":57,"status":58,"city":887,"state":888,"zip":889,"country":890,"countryCode":891,"cosmosGeoPoint":892,"geoPoint":896,"contacts":34},"Krakow","Lesser Poland Voivodeship","31-826","Poland","PL",{"type":65,"coordinates":893},[894,895],19.93658,50.06143,{"lat":895,"lon":894},{"facility":57,"status":58,"city":898,"state":899,"zip":900,"country":890,"countryCode":891,"cosmosGeoPoint":901,"geoPoint":905,"contacts":34},"Rzeszów","Podkarpackie Voivodeship","35-055",{"type":65,"coordinates":902},[903,904],21.99901,50.04132,{"lat":904,"lon":903},{"facility":57,"status":58,"city":898,"state":899,"zip":907,"country":890,"countryCode":891,"cosmosGeoPoint":908,"geoPoint":910,"contacts":34},"35-922",{"type":65,"coordinates":909},[903,904],{"lat":904,"lon":903},{"facility":57,"status":58,"city":912,"state":913,"zip":914,"country":890,"countryCode":891,"cosmosGeoPoint":915,"geoPoint":919,"contacts":34},"Brzozów","Woj Podkarpackie","36-200",{"type":65,"coordinates":916},[917,918],22.01926,49.69501,{"lat":918,"lon":917},{"facility":57,"status":105,"city":921,"state":922,"zip":923,"country":890,"countryCode":891,"cosmosGeoPoint":924,"geoPoint":928,"contacts":34},"Lodz","Łódź Voivodeship","90-302",{"type":65,"coordinates":925},[926,927],19.47395,51.77058,{"lat":927,"lon":926},{"facility":57,"status":105,"city":930,"state":931,"zip":932,"country":933,"countryCode":934,"cosmosGeoPoint":935,"geoPoint":939,"contacts":34},"Lisbon","Lisbon District","1099-023","Portugal","PT",{"type":65,"coordinates":936},[937,938],-9.1498,38.72509,{"lat":938,"lon":937},{"facility":57,"status":58,"city":941,"state":942,"zip":943,"country":933,"countryCode":934,"cosmosGeoPoint":944,"geoPoint":948,"contacts":34},"Porto","Porto District","4464-513",{"type":65,"coordinates":945},[946,947],-8.61097,41.1485,{"lat":947,"lon":946},{"facility":57,"status":58,"city":950,"state":950,"zip":951,"country":952,"countryCode":953,"cosmosGeoPoint":954,"geoPoint":958,"contacts":34},"Bucharest","11171","Romania","RO",{"type":65,"coordinates":955},[956,957],26.10626,44.43225,{"lat":957,"lon":956},{"facility":57,"status":105,"city":960,"state":961,"zip":962,"country":952,"countryCode":953,"cosmosGeoPoint":963,"geoPoint":967,"contacts":34},"Cluj-Napoca","Cluj","400641",{"type":65,"coordinates":964},[965,966],23.6,46.76667,{"lat":966,"lon":965},{"facility":57,"status":58,"city":969,"state":970,"zip":971,"country":952,"countryCode":953,"cosmosGeoPoint":972,"geoPoint":976,"contacts":34},"Ovidiu","Constanța County","905900",{"type":65,"coordinates":973},[974,975],28.56083,44.258,{"lat":975,"lon":974},{"facility":57,"status":105,"city":978,"state":979,"zip":980,"country":952,"countryCode":953,"cosmosGeoPoint":981,"geoPoint":985,"contacts":34},"Craiova","Dolj","200542",{"type":65,"coordinates":982},[983,984],23.8,44.31667,{"lat":984,"lon":983},{"facility":57,"status":105,"city":987,"state":988,"zip":989,"country":952,"countryCode":953,"cosmosGeoPoint":990,"geoPoint":994,"contacts":34},"Iași","Iaşi","700106",{"type":65,"coordinates":991},[992,993],27.6,47.16667,{"lat":993,"lon":992},{"facility":57,"status":58,"city":996,"state":997,"zip":998,"country":952,"countryCode":953,"cosmosGeoPoint":999,"geoPoint":1003,"contacts":34},"Timișoara","Timiș County","300239",{"type":65,"coordinates":1000},[1001,1002],21.22571,45.75372,{"lat":1002,"lon":1001},{"facility":57,"status":58,"city":1005,"state":1006,"zip":1007,"country":1008,"countryCode":34,"cosmosGeoPoint":1009,"geoPoint":1013,"contacts":34},"Busan","Busan Metropolitan City","49201","South Korea",{"type":65,"coordinates":1010},[1011,1012],129.03004,35.10168,{"lat":1012,"lon":1011},{"facility":57,"status":105,"city":1015,"state":1016,"zip":1017,"country":1008,"countryCode":34,"cosmosGeoPoint":1018,"geoPoint":1022,"contacts":34},"Daegu","Daegu Metropolitan City","41404",{"type":65,"coordinates":1019},[1020,1021],128.59111,35.87028,{"lat":1021,"lon":1020},{"facility":57,"status":105,"city":1024,"state":1025,"zip":1026,"country":1008,"countryCode":34,"cosmosGeoPoint":1027,"geoPoint":1031,"contacts":34},"Goyang-si","Gyeonggi-do","10408",{"type":65,"coordinates":1028},[1029,1030],126.835,37.65639,{"lat":1030,"lon":1029},{"facility":57,"status":105,"city":1033,"state":1025,"zip":1034,"country":1008,"countryCode":34,"cosmosGeoPoint":1035,"geoPoint":1039,"contacts":34},"Seongnam-si","13620",{"type":65,"coordinates":1036},[1037,1038],127.13778,37.43861,{"lat":1038,"lon":1037},{"facility":57,"status":105,"city":1041,"state":1025,"zip":1042,"country":1008,"countryCode":34,"cosmosGeoPoint":1043,"geoPoint":1047,"contacts":34},"Suwon","16247",{"type":65,"coordinates":1044},[1045,1046],127.00889,37.29111,{"lat":1046,"lon":1045},{"facility":57,"status":58,"city":1049,"state":1025,"zip":1050,"country":1008,"countryCode":34,"cosmosGeoPoint":1051,"geoPoint":1055,"contacts":34},"Yongin-si","16499",{"type":65,"coordinates":1052},[1053,1054],127.08042,37.29686,{"lat":1054,"lon":1053},{"facility":57,"status":58,"city":1057,"state":1057,"zip":1058,"country":1008,"countryCode":34,"cosmosGeoPoint":1059,"geoPoint":1063,"contacts":34},"Seoul","02841",{"type":65,"coordinates":1060},[1061,1062],126.9784,37.566,{"lat":1062,"lon":1061},{"facility":1065,"status":105,"city":1057,"state":1057,"zip":1066,"country":1008,"countryCode":34,"cosmosGeoPoint":1067,"geoPoint":1069,"contacts":34},"Clinical Trial Site 1","03080",{"type":65,"coordinates":1068},[1061,1062],{"lat":1062,"lon":1061},{"facility":1071,"status":105,"city":1057,"state":1057,"zip":1066,"country":1008,"countryCode":34,"cosmosGeoPoint":1072,"geoPoint":1074,"contacts":34},"Clinical Trial Site 2",{"type":65,"coordinates":1073},[1061,1062],{"lat":1062,"lon":1061},{"facility":57,"status":105,"city":1057,"state":1057,"zip":1076,"country":1008,"countryCode":34,"cosmosGeoPoint":1077,"geoPoint":1079,"contacts":34},"03722",{"type":65,"coordinates":1078},[1061,1062],{"lat":1062,"lon":1061},{"facility":57,"status":105,"city":1057,"state":1081,"zip":1082,"country":1008,"countryCode":34,"cosmosGeoPoint":1083,"geoPoint":1085,"contacts":34},"Seoul Special City","05505",{"type":65,"coordinates":1084},[1061,1062],{"lat":1062,"lon":1061},{"facility":57,"status":58,"city":1057,"state":1081,"zip":1087,"country":1008,"countryCode":34,"cosmosGeoPoint":1088,"geoPoint":1090,"contacts":34},"08308",{"type":65,"coordinates":1089},[1061,1062],{"lat":1062,"lon":1061},{"facility":57,"status":58,"city":1092,"state":1092,"zip":1093,"country":1094,"countryCode":1095,"cosmosGeoPoint":1096,"geoPoint":1100,"contacts":34},"Alicante","3010","Spain","ES",{"type":65,"coordinates":1097},[1098,1099],-0.48149,38.34517,{"lat":1099,"lon":1098},{"facility":57,"status":105,"city":1102,"state":1102,"zip":1103,"country":1094,"countryCode":1095,"cosmosGeoPoint":1104,"geoPoint":1108,"contacts":34},"Barcelona","08028",{"type":65,"coordinates":1105},[1106,1107],2.15899,41.38879,{"lat":1107,"lon":1106},{"facility":57,"status":58,"city":1102,"state":1102,"zip":1110,"country":1094,"countryCode":1095,"cosmosGeoPoint":1111,"geoPoint":1113,"contacts":34},"08035",{"type":65,"coordinates":1112},[1106,1107],{"lat":1107,"lon":1106},{"facility":57,"status":105,"city":1102,"state":1102,"zip":1115,"country":1094,"countryCode":1095,"cosmosGeoPoint":1116,"geoPoint":1118,"contacts":34},"08036",{"type":65,"coordinates":1117},[1106,1107],{"lat":1107,"lon":1106},{"facility":57,"status":105,"city":1120,"state":1120,"zip":1121,"country":1094,"countryCode":1095,"cosmosGeoPoint":1122,"geoPoint":1126,"contacts":34},"Granada","18012",{"type":65,"coordinates":1123},[1124,1125],-3.60667,37.18817,{"lat":1125,"lon":1124},{"facility":57,"status":58,"city":1128,"state":1128,"zip":1129,"country":1094,"countryCode":1095,"cosmosGeoPoint":1130,"geoPoint":1134,"contacts":34},"León","24071",{"type":65,"coordinates":1131},[1132,1133],-5.57032,42.60003,{"lat":1133,"lon":1132},{"facility":57,"status":58,"city":1136,"state":1136,"zip":1137,"country":1094,"countryCode":1095,"cosmosGeoPoint":1138,"geoPoint":1142,"contacts":34},"Lleida","25198",{"type":65,"coordinates":1139},[1140,1141],0.62218,41.61674,{"lat":1141,"lon":1140},{"facility":57,"status":58,"city":1144,"state":1144,"zip":1145,"country":1094,"countryCode":1095,"cosmosGeoPoint":1146,"geoPoint":1150,"contacts":34},"Madrid","28007",{"type":65,"coordinates":1147},[1148,1149],-3.70256,40.4165,{"lat":1149,"lon":1148},{"facility":57,"status":105,"city":1144,"state":1144,"zip":1152,"country":1094,"countryCode":1095,"cosmosGeoPoint":1153,"geoPoint":1155,"contacts":34},"28040",{"type":65,"coordinates":1154},[1148,1149],{"lat":1149,"lon":1148},{"facility":57,"status":58,"city":1144,"state":1144,"zip":1157,"country":1094,"countryCode":1095,"cosmosGeoPoint":1158,"geoPoint":1160,"contacts":34},"28046",{"type":65,"coordinates":1159},[1148,1149],{"lat":1149,"lon":1148},{"facility":57,"status":105,"city":1144,"state":1144,"zip":1162,"country":1094,"countryCode":1095,"cosmosGeoPoint":1163,"geoPoint":1165,"contacts":34},"28050",{"type":65,"coordinates":1164},[1148,1149],{"lat":1149,"lon":1148},{"facility":57,"status":105,"city":1167,"state":1167,"zip":1168,"country":1094,"countryCode":1095,"cosmosGeoPoint":1169,"geoPoint":1173,"contacts":34},"Murcia","30120",{"type":65,"coordinates":1170},[1171,1172],-1.13004,37.98704,{"lat":1172,"lon":1171},{"facility":57,"status":58,"city":1175,"state":1176,"zip":1177,"country":1094,"countryCode":1095,"cosmosGeoPoint":1178,"geoPoint":1182,"contacts":34},"Seville","Sevilla","41009",{"type":65,"coordinates":1179},[1180,1181],-5.97317,37.38283,{"lat":1181,"lon":1180},{"facility":57,"status":105,"city":1184,"state":1184,"zip":1185,"country":1094,"countryCode":1095,"cosmosGeoPoint":1186,"geoPoint":1190,"contacts":34},"Valencia","46010",{"type":65,"coordinates":1187},[1188,1189],-0.37966,39.47391,{"lat":1189,"lon":1188},{"facility":57,"status":58,"city":1192,"state":1192,"zip":1193,"country":1094,"countryCode":1095,"cosmosGeoPoint":1194,"geoPoint":1198,"contacts":34},"Zaragoza","50009",{"type":65,"coordinates":1195},[1196,1197],-0.87734,41.65606,{"lat":1197,"lon":1196},{"facility":57,"status":58,"city":1200,"state":1201,"zip":1202,"country":1203,"countryCode":1204,"cosmosGeoPoint":1205,"geoPoint":1209,"contacts":34},"Chang-hua","Chang Hua","50006","Taiwan","TW",{"type":65,"coordinates":1206},[1207,1208],120.56276,24.07327,{"lat":1208,"lon":1207},{"facility":57,"status":105,"city":1211,"state":1212,"zip":1213,"country":1203,"countryCode":1204,"cosmosGeoPoint":1214,"geoPoint":1218,"contacts":34},"Kaohsiung City","Sanmin","80756",{"type":65,"coordinates":1215},[1216,1217],120.31333,22.61626,{"lat":1217,"lon":1216},{"facility":57,"status":105,"city":1220,"state":1221,"zip":1222,"country":1203,"countryCode":1204,"cosmosGeoPoint":1223,"geoPoint":1227,"contacts":34},"Taipei","Special Municipality","11217",{"type":65,"coordinates":1224},[1225,1226],121.52639,25.05306,{"lat":1226,"lon":1225},{"facility":57,"status":105,"city":1220,"state":1221,"zip":1229,"country":1203,"countryCode":1204,"cosmosGeoPoint":1230,"geoPoint":1232,"contacts":34},"11490",{"type":65,"coordinates":1231},[1225,1226],{"lat":1226,"lon":1225},{"facility":57,"status":105,"city":1220,"state":1234,"zip":1235,"country":1203,"countryCode":1204,"cosmosGeoPoint":1236,"geoPoint":1238,"contacts":34},"Taipei City","100",{"type":65,"coordinates":1237},[1225,1226],{"lat":1226,"lon":1225},{"facility":57,"status":105,"city":1220,"state":1234,"zip":1240,"country":1203,"countryCode":1204,"cosmosGeoPoint":1241,"geoPoint":1243,"contacts":34},"10449",{"type":65,"coordinates":1242},[1225,1226],{"lat":1226,"lon":1225},{"facility":57,"status":105,"city":1245,"state":1245,"zip":1246,"country":1247,"countryCode":1248,"cosmosGeoPoint":1249,"geoPoint":1253,"contacts":34},"Bangkok","10700","Thailand","TH",{"type":65,"coordinates":1250},[1251,1252],100.50144,13.75398,{"lat":1252,"lon":1251},{"facility":57,"status":105,"city":1255,"state":1245,"zip":1256,"country":1247,"countryCode":1248,"cosmosGeoPoint":1257,"geoPoint":1261,"contacts":34},"Dusit","10300",{"type":65,"coordinates":1258},[1259,1260],100.51958,13.77706,{"lat":1260,"lon":1259},{"facility":57,"status":105,"city":1263,"state":1264,"zip":1265,"country":1247,"countryCode":1248,"cosmosGeoPoint":1266,"geoPoint":1270,"contacts":34},"Ban Phaeo","Changwat Samut Sakhon","74120",{"type":65,"coordinates":1267},[1268,1269],100.10748,13.59072,{"lat":1269,"lon":1268},{"facility":57,"status":105,"city":1272,"state":1273,"zip":1274,"country":1247,"countryCode":1248,"cosmosGeoPoint":1275,"geoPoint":1279,"contacts":34},"Hat Yai","Changwat Songkhla","90110",{"type":65,"coordinates":1276},[1277,1278],100.47668,7.00836,{"lat":1278,"lon":1277},{"facility":57,"status":105,"city":1281,"state":1281,"zip":1282,"country":1247,"countryCode":1248,"cosmosGeoPoint":1283,"geoPoint":1287,"contacts":34},"Chiang Mai","50200",{"type":65,"coordinates":1284},[1285,1286],98.98468,18.79038,{"lat":1286,"lon":1285},{"facility":57,"status":105,"city":1289,"state":1290,"zip":1291,"country":1292,"countryCode":1293,"cosmosGeoPoint":1294,"geoPoint":1298,"contacts":34},"Brighton","England","BN2 5BE","United Kingdom","UK",{"type":65,"coordinates":1295},[1296,1297],-0.13947,50.82838,{"lat":1297,"lon":1296},{"facility":57,"status":58,"city":1300,"state":1290,"zip":1301,"country":1292,"countryCode":1293,"cosmosGeoPoint":1302,"geoPoint":1306,"contacts":34},"London","WC1E 6AG",{"type":65,"coordinates":1303},[1304,1305],-0.12574,51.50853,{"lat":1305,"lon":1304},{"facility":57,"status":105,"city":1300,"state":1308,"zip":1309,"country":1292,"countryCode":1293,"cosmosGeoPoint":1310,"geoPoint":1312,"contacts":34},"Greater London","EC1M 6BQ",{"type":65,"coordinates":1311},[1304,1305],{"lat":1305,"lon":1304},{"facility":57,"status":105,"city":1314,"state":1315,"zip":1316,"country":1292,"countryCode":1293,"cosmosGeoPoint":1317,"geoPoint":1321,"contacts":34},"Taunton","Somerset","TA1 5DA",{"type":65,"coordinates":1318},[1319,1320],-3.10293,51.01494,{"lat":1320,"lon":1319},{"facility":57,"status":105,"city":1323,"state":1324,"zip":1325,"country":1292,"countryCode":1293,"cosmosGeoPoint":1326,"geoPoint":1330,"contacts":34},"Guildford","Surrey","GU2 7XX",{"type":65,"coordinates":1327},[1328,1329],-0.57427,51.23536,{"lat":1329,"lon":1328},{"type":1332,"investigatorFullName":34,"investigatorTitle":34,"investigatorAffiliation":34,"oldNameTitle":34,"oldOrganization":34},"SPONSOR",[1334],{"name":1335,"class":6},"Novartis Pharmaceuticals","100599536",false,"NCT07085767","Palazestrant in Combination With Ribociclib for the First-line Treatment of ER+\u002FHER2- Advanced Breast Cancer","A Phase 3 Randomized, Double-Blind, Active-Controlled Study of Palazestrant With Ribociclib Versus Letrozole With Ribociclib for the First-Line Treatment of ER+, HER2- Advanced Breast Cancer (OPERA-02)","OPERA-02","Inclusion Criteria:\n\n* Adult female or male participants.\n* ER+, HER2- locally advanced or metastatic breast cancer that is not amenable to curative therapy.\n* Evaluable disease (measurable disease per RECIST 1.1 or bone-only disease).\n* De novo advanced breast cancer or with disease recurrence occurring after 12 months of completing adjuvant endocrine therapy (with or without CDK4\u002F6 inhibitors)\n* Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1.\n* Adequate hematologic, hepatic, and renal functions.\n* Female participants can be pre-, peri- or postmenopausal.\n* Male and pre- or peri-menopausal female participants must be willing to take a GnRH (or LHRH) agonist.\n\nExclusion Criteria:\n\n* Disease recurrence during adjuvant endocrine therapy\n* Currently receiving or previously received systemic anti-cancer therapy for ER+, HER2- advanced breast cancer.\n* Previously received treatment with fulvestrant, elacestrant or an investigational endocrine therapy in any setting.\n* History of allergic reactions to study treatment.\n* Any contraindications to letrozole and ribociclib.\n* Symptomatic central nervous system metastases, carcinomatous meningitis, leptomeningeal disease, or a spinal cord compression that require immediate treatment.","ALL","18 Years",{"count":1346,"type":1347},1000,"ESTIMATED","INTERVENTIONAL",[1350],"PHASE3","This phase 3 clinical trial compares the efficacy and safety of palazestrant with ribociclib to letrozole and ribociclib in women and men who have not received prior systemic anti-cancer treatment for advanced breast cancer.",[1353,1354,1355,1356,1357],"Breast Cancer","Locally Advanced Breast Cancer","Metastatic Breast Cancer","ER Positive Breast Cancer","HER2 Negative Breast Carcinoma",[1359,1360,1361,1362,1363,9,1364,1365,36,1366,17,1367,1368],"Randomized","Multicenter","Double-Blind","Active-Controlled","Phase 3","Complete Estrogen Receptor Antagonist (CERAN)","Selective Estrogen Receptor Degrader (SERD)","CDK4\u002F6i","Aromatase inhibitors","Antineoplastic agents","2026-06-12",{"date":1371,"type":1372},"2026-06-16","ACTUAL",{"date":1374,"type":1372},"2025-11-03",{"date":1376,"type":1347},"2032-01",{"name":5,"class":6},150]