This study is being done to answer the following question: Does stereotactic body radiation therapy (SBRT) provide better cancer control compared to standard radiation therapy (RT) for those with advanced head and neck cancer?
Histologically confirmed mucosal squamous cell carcinoma (SCC) of the head and neck arising from at least one of the following sites: oro/hypopharynx, oral cavity, supraglottic larynx, maxillary sinus, nasal cavity, or unknown primary
Stages TX or T0-T4/N0-N3
Must be considered unfit for curative intent RT as determined by the treating oncologist(s)
Geriatric 8 score <14
Patients with nasopharyngeal carcinoma.
Prior systemic therapy (including immunotherapy).
Prior radiotherapy to the head and neck excluding superficial radiotherapy for head and neck skin cancer that does not overlap with current protocol treatment.
Prior head and neck cancer excluding skin cancer.
Canadian Cancer Trials Group
Lead sponsor
Canadian Institutes of Health Research (CIHR)
Collaborator