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1BB",{"type":110,"coordinates":2437},[2438,2439],-0.12574,51.50853,{"lat":2439,"lon":2438},{"facility":102,"status":116,"city":2434,"state":38,"zip":2442,"country":2410,"countryCode":2411,"cosmosGeoPoint":2443,"geoPoint":2445,"contacts":38},"W2 1NY",{"type":110,"coordinates":2444},[2438,2439],{"lat":2439,"lon":2438},{"facility":102,"status":116,"city":2447,"state":38,"zip":2448,"country":2410,"countryCode":2411,"cosmosGeoPoint":2449,"geoPoint":2453,"contacts":38},"Manchester","M20 4BX",{"type":110,"coordinates":2450},[2451,2452],-2.23743,53.48095,{"lat":2452,"lon":2451},{"facility":102,"status":103,"city":2455,"state":38,"zip":2456,"country":2410,"countryCode":2411,"cosmosGeoPoint":2457,"geoPoint":2461,"contacts":38},"Northwood","HA6 2RN",{"type":110,"coordinates":2458},[2459,2460],-0.42454,51.61162,{"lat":2460,"lon":2459},{"facility":102,"status":116,"city":2463,"state":38,"zip":2464,"country":2410,"countryCode":2411,"cosmosGeoPoint":2465,"geoPoint":2469,"contacts":38},"Truro","TR1 3LJ",{"type":110,"coordinates":2466},[2467,2468],-5.05436,50.26526,{"lat":2468,"lon":2467},{"type":2471,"investigatorFullName":38,"investigatorTitle":38,"investigatorAffiliation":38,"oldNameTitle":38,"oldOrganization":38},"SPONSOR","100596352",false,"NCT07044336","Puxitatug Samrotecan (AZD8205) Monotherapy vs Chemotherapy in B7-H4-selected Endometrial Cancer (Bluestar-Endometrial01)","Puxitatug Samrotecan (AZD8205) Monotherapy vs Chemotherapy in B7-H4 Selected Advanced\u002FMetastatic Endometrial Cancer Who Progressed On or After Platinum Based Chemotherapy and Anti-PD-1\u002FAnti-PD-L1 Therapy (Bluestar-Endometrial01)","The main inclusion criteria include but are not limited to the following:\n\n* Histologically confirmed diagnosis of endometrial carcinoma or carcinosarcoma.\n* Recurrent\u002Fmetastatic EC ie, with radiological or objective evidence of recurrence or progression.\n* Has received prior platinum-based chemotherapy and anti-programmed cell death 1 protein (PD-1)\u002Fanti- programmed cell death ligand 1 (PD-L1) therapy, either separately or in combination.\n* A WHO\u002FECOG performance status of 0 or 1 at Screening.\n* Has radiographically measurable disease by RECIST 1.1\n\nThe main exclusion criteria include but are not limited to the following:\n\n* Had uterine sarcomas or uterine neuroendocrine carcinoma.\n* Has had a recurrence of endometrial carcinoma or carcinosarcoma more than \\> 12 months after completing platinum-based therapy administered in the curative-intent setting without any additional platinum-based therapy received in the recurrent setting.\n* Had previously received treatment with any therapy (approved or investigational) that contained a TOP1i including ADCs .\n* Had previously received treatment with Puxi-Sam or another B7-H4 targeting agent.\n* History of (non-infectious) ILD\u002Fpneumonitis that required steroids, has current ILD\u002Fpneumonitis, or where suspected ILD\u002Fpneumonitis cannot be ruled out by imaging at screening.\n* Has clinically severe pulmonary compromise resulting from intercurrent pulmonary illnesses.\n* Active or previously documented autoimmune or inflammatory disorders","FEMALE","18 Years",{"count":2481,"type":2482},800,"ESTIMATED","INTERVENTIONAL",[2485],"PHASE3","This is a Phase III, 2-arm, randomized, open label, multicenter, global study assessing the efficacy and safety of puxitatug samrotecan compared to physician's choice of chemotherapy (doxorubicin or paclitaxel) in participants with B7-H4 selected advanced\u002Fmetastatic EC that progressed following platinum based chemotherapy and anti-PD-1\u002Fanti-PD-L1 therapy.",[2488,2489],"Endometrial Cancer","Malignant Solid Tumour",[2491,2492,52,70,2493,2494,2495,2488,2496,2497,2498,2499,2500,2501],"Bluestar-Endometrial01","AZD8205","Platinum-based chemotherapy","B7-H4","advanced\u002Fmetastatic","Anti-PD-1","Anti-PD-L1","antibody-drug conjugate","Topoisomerase 1 Inhibitors","uterine neoplasm","female urogenital neoplasm","2026-06-09",{"date":2504,"type":2505},"2026-06-10","ACTUAL",{"date":2507,"type":2505},"2025-08-01",{"date":2509,"type":2482},"2029-07-17",{"name":5,"class":6},317]