[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100564120":3},{"organization":4,"armGroups":7,"interventions":24,"overallOfficials":94,"centralContacts":98,"locations":107,"responsibleParty":142,"collaborators":83,"id":144,"slug":83,"hasResults":145,"nctId":146,"briefTitle":147,"officialTitle":148,"acronym":83,"eligibilityCriteria":149,"healthyVolunteers":145,"sex":150,"minAge":151,"maxAge":83,"enrollmentInfo":152,"targetDuration":83,"studyType":155,"phases":156,"briefSummary":158,"conditions":159,"keywords":83,"overallStatus":110,"whyStopped":83,"lastUpdateSubmitDate":161,"lastUpdatePostDateStruct":162,"startDateStruct":165,"completionDateStruct":167,"leadSponsor":169,"locationsCount":170},{"fullName":5,"class":6},"Mayo Clinic","OTHER",[8,19],{"label":9,"type":10,"description":11,"interventionNames":12},"Arm A (human-driven treatment planning, radiation therapy)","ACTIVE_COMPARATOR","Patients receive human-driven treatment planning and undergo radiation therapy over 15-30 minutes on 5-44 fractions per standard of care. Additionally, patients undergo MRI pre-treatment and blood sample collection and PET throughout study.",[13,14,15,16,17,18],"Procedure: Biospecimen Collection","Procedure: Magnetic Resonance Imaging","Radiation: Photon Beam Radiation Therapy","Procedure: Positron Emission Tomography","Other: Questionnaire Administration","Radiation: Radiation Therapy Treatment Planning and Simulation",{"label":20,"type":21,"description":22,"interventionNames":23},"Arm B (RapidPlan treatment planning, radiation therapy)","EXPERIMENTAL","Patients receive RapidPlan treatment planning and undergo radiation therapy over 15-30 minutes on 5-44 fractions per standard of care. Additionally, patients undergo MRI pre-treatment and blood sample collection and PET throughout study.",[13,14,15,16,17,18],[25,34,54,66,79,84,90],{"type":26,"name":27,"description":28,"armGroupLabels":29,"otherNames":30},"PROCEDURE","Biospecimen Collection","Undergo blood sample collection",[9,20],[31,32,33],"Biological Sample Collection","Biospecimen Collected","Specimen Collection",{"type":26,"name":35,"description":36,"armGroupLabels":37,"otherNames":38},"Magnetic Resonance Imaging","Undergo MRI",[9,20],[39,40,41,42,43,44,45,46,47,48,49,50,51,52,53],"Magnetic Resonance","Magnetic Resonance Imaging (MRI)","Magnetic resonance imaging (procedure)","Magnetic Resonance Imaging Scan","Medical Imaging, Magnetic Resonance \u002F Nuclear Magnetic Resonance","MR","MR Imaging","MRI","MRI Scan","MRIs","NMR Imaging","NMRI","Nuclear Magnetic Resonance Imaging","sMRI","Structural MRI",{"type":55,"name":56,"description":57,"armGroupLabels":58,"otherNames":59},"RADIATION","Photon Beam Radiation Therapy","Undergo radiation therapy",[9,20],[60,61,62,63,64,65],"External beam radiation therapy using photons (procedure)","Photon","Photon EBRT","Photon External Beam Radiotherapy","PHOTON Therapy","Radiation, Photon Beam",{"type":26,"name":67,"description":68,"armGroupLabels":69,"otherNames":70},"Positron Emission Tomography","Undergo PET",[9,20],[71,72,73,74,75,76,77,78],"Medical Imaging, Positron Emission Tomography","PET","PET Scan","Positron emission tomography (procedure)","Positron Emission Tomography Scan","Positron-Emission Tomography","proton magnetic resonance spectroscopic imaging","PT",{"type":6,"name":80,"description":81,"armGroupLabels":82,"otherNames":83},"Questionnaire Administration","Ancillary studies",[9,20],null,{"type":55,"name":85,"description":86,"armGroupLabels":87,"otherNames":88},"Radiation Therapy Treatment Planning and Simulation","Receive human-driven treatment planning",[9],[89],"Radiation Therapy Treatment Planning\u002FSimulation",{"type":55,"name":85,"description":91,"armGroupLabels":92,"otherNames":93},"Receive RapidPlan treatment planning",[20],[89],[95],{"name":96,"affiliation":5,"role":97},"Nathan Y. Yu, MD","PRINCIPAL_INVESTIGATOR",[99,104],{"name":100,"role":101,"phone":102,"phoneExt":83,"email":103},"Clinical Trials Referral Office","CONTACT","855-776-0015","mayocliniccancerstudies@mayo.edu",{"name":105,"role":101,"phone":106,"phoneExt":83,"email":83},"Cancer Clinical Trials Referral Office","507-293-6386",[108,126],{"facility":109,"status":110,"city":111,"state":112,"zip":113,"country":114,"countryCode":115,"cosmosGeoPoint":116,"geoPoint":121,"contacts":122},"Mayo Clinic in Arizona","RECRUITING","Scottsdale","Arizona","85259","United States","US",{"type":117,"coordinates":118},"Point",[119,120],-111.89903,33.50921,{"lat":120,"lon":119},[123,124,125],{"name":100,"role":101,"phone":102,"phoneExt":83,"email":103},{"name":105,"role":101,"phone":106,"phoneExt":83,"email":83},{"name":96,"role":97,"phone":83,"phoneExt":83,"email":83},{"facility":127,"status":128,"city":129,"state":130,"zip":131,"country":114,"countryCode":115,"cosmosGeoPoint":132,"geoPoint":136,"contacts":137},"Mayo Clinic in Florida","NOT_YET_RECRUITING","Jacksonville","Florida","32224-9980",{"type":117,"coordinates":133},[134,135],-81.65565,30.33218,{"lat":135,"lon":134},[138,139,140],{"name":100,"role":101,"phone":102,"phoneExt":83,"email":103},{"name":105,"role":101,"phone":106,"phoneExt":83,"email":83},{"name":141,"role":97,"phone":83,"phoneExt":83,"email":83},"Homan Mohammadi, MD",{"type":143,"investigatorFullName":83,"investigatorTitle":83,"investigatorAffiliation":83,"oldNameTitle":83,"oldOrganization":83},"SPONSOR","100564120",false,"NCT06625034","Radiation Therapy With RapidPlan Knowledge-based Planning vs Human-Driven Planning for Treatment of Prostate Cancer","Randomized Phase III Trial of Rapid-Plan Knowledge-Based Planning vs. Human-Driven Planning for Prostate Cancer Radiotherapy","Inclusion Criteria:\n\n* Patients must be at least 18 years old\n* Histologically confirmed prostate cancer\n* Clinical or pathologic stages T1c-T3b, Nx or N0-1, M0-1 (American Joint Committee on Cancer \\[AJCC\\] criteria 8th edition \\[Ed\\])\n* Planned definitive dose radiotherapy to the prostate or prostate bed\n* Eastern Cooperative Oncology Group (ECOG) performance status 0-2 assessed within 90 days of enrollment\n* Patients must sign Institutional Review Board (IRB) approved study specific informed consent\n* Patients must complete all required pre-entry tests within the specified time frames\n* Patients must be able to start treatment (radiation) within 180 days of study registration\n* In case of confusion about the eligibility or ineligibility of an individual patient, the principal investigator (PI) can be used as the arbiter and a note to file will be added to the subject's regulatory binder to document outcome\n\nExclusion Criteria:\n\n* Previous pelvic radiation \\> 5 Gy\n* Planned delivery of radiotherapy to pelvic lymph nodes\n* Planned delivery of brachytherapy of the prostate\n* Active rectal diverticulitis, Crohn's disease affecting the rectum, or ulcerative colitis (non-active diverticulitis and Crohn's disease not affecting the rectum are allowed)\n* Prior hip replacement or penile implant\n* Major medical, addictive, or psychiatric illness which in the investigator's opinion, will prevent the consent process, completion of the treatment and\u002For interfere with follow-up. (consent by legal authorized representative is not permitted for this study)\n* Indwelling or intermittent urinary catheter use","MALE","18 Years",{"count":153,"type":154},108,"ESTIMATED","INTERVENTIONAL",[157],"PHASE3","This phase III trial compares the effects of radiation therapy using RapidPlan, trademark, knowledge-based planning to human-driven planning in treating patients with prostate cancer. Radiation therapy uses high energy x-rays, particles, or radioactive seeds to kill tumor cells and shrink tumors. Successful delivery of radiation requires planning to develop a treatment plan for how and where the radiation is to be delivered. RapidPlan is a knowledge-based treatment planning tool that automatically creates an optimal treatment plan based on identified targets and organs at risk for radiation exposure. Human-driven treatment planning by a dosimetrist, the current standard of care, requires significant resources and time and may vary within and among radiation centers. Giving radiation therapy with RapidPlan knowledge-based planning may have similar or less side effects compared to human-driven planning in treating patients with prostate cancer.",[160],"Prostate Carcinoma","2026-06-16",{"date":163,"type":164},"2026-06-18","ACTUAL",{"date":166,"type":164},"2025-02-02",{"date":168,"type":154},"2033-05-28",{"name":5,"class":6},2]