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The doses of other antiproteinuric medications including mycophenolic acid, corticosteroids and mineralocorticoid receptor antagonists should be stable for at least 90 days prior to randomization.\n* Reduced serum C3 (defined as less than 0.85 x lower limit of the central laboratory normal range) at Screening.\n* UPCR ≥ 1.0 g\u002Fg sampled from the first morning void urine sample at Day -75 and Day -15.\n* Estimated GFR (using the CKD-EPI formula for ages ≥ 18 years and modified Schwartz formula for ages 12 to 17 years) or measured GFR ≥ 30 ml\u002Fmin\u002F1.73m2 at screening and Day -15.\n* Mandatory vaccination against Neisseria meningitidis and Streptococcus pneumoniae prior to the start of study treatment.\n* If not previously vaccinated or if a booster is required, vaccination against Haemophilus influenzae infections should be given, if available and according to local regulations, at least 2 weeks prior to the first study treatment administration. If study treatment has to start earlier than 2 weeks post vaccination, prophylactic antibiotic treatment should be initiated.\n\nExclusion Criteria:\n\n* Participants who have received any cell or organ transplantation, including a kidney transplantation.\n* Rapidly progressive crescentic glomerulonephritis defined as a 50% decline in the eGFR within 3 months with renal biopsy findings of glomerular crescent formation seen in at least 50% of glomeruli.\n* Renal biopsy showing interstitial fibrosis\u002Ftubular atrophy (IF\u002FTA) of more than 50%\n* Monoclonal gammopathy of undetermined significance (MGUS) confirmed by the measurement of serum free light chains or other investigation as per local standard of care.\n* Participants with an active systemic bacterial, viral or fungal infection within 14 days prior to study treatment administration\n* The presence of fever ≥ 38°C (100.4°F) within 7 days prior to study treatment administration.\n* A history of recurrent invasive infections caused by encapsulated organisms, e.g., N. meningitidis and S. pneumoniae.\n* The use of inhibitors of complement factors (e.g., Factor B, Factor D, C3 inhibitors, anti C5 antibodies, C5a receptor antagonists) within 6 months prior to the Screening visit.\n* The use of immunosuppressants (except mycophenolic acids), cyclophosphamide or systemic corticosteroids at a dose \\>7.5 mg\u002Fday (or equivalent for a similar medication) within 90 days of study drug administration.\n* Acute post-infectious glomerulonephritis at screening based upon the opinion of the investigator.","ALL","12 Years","60 Years",{"count":898,"type":899},98,"ESTIMATED","INTERVENTIONAL",[902],"PHASE3","The Primary Completion Date and Study Completion Date have been updated to reflect completion of the adolescent cohort, which has been added to the protocol.\n\nThe study is designed as a multicenter, randomized, double-blind, parallel group, placebo-controlled study to evaluate the efficacy and safety of iptacopan (LNP023) in complement 3 glomerulopathy.",[905],"C3G",[99,95,905,907,908,909,910],"UPCR","eGFR","proteinuria","Quality of life","2026-07-09",{"date":913,"type":914},"2026-07-13","ACTUAL",{"date":916,"type":914},"2021-07-28",{"date":918,"type":899},"2027-01-29",{"name":102,"class":6},87]