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Majadahonda \u002FID# 263179","Majadahonda","Madrid","28222",{"type":56,"coordinates":1122},[1123,1124],-3.87182,40.47353,{"lat":1124,"lon":1123},{"facility":1127,"status":49,"city":1128,"state":1129,"zip":1130,"country":1099,"countryCode":1100,"cosmosGeoPoint":35,"geoPoint":35,"contacts":35},"Instituto Oftalmológico Fernández-Vega \u002FID# 263157","Asturias","Principality of Asturias","33012",{"facility":1132,"status":49,"city":1133,"state":1134,"zip":1135,"country":1099,"countryCode":1100,"cosmosGeoPoint":1136,"geoPoint":1140,"contacts":35},"Hospital Universitario Virgen Macarena \u002FID# 263180","Seville","Sevilla","41009",{"type":56,"coordinates":1137},[1138,1139],-5.97317,37.38283,{"lat":1139,"lon":1138},{"facility":1142,"status":49,"city":1143,"state":35,"zip":1144,"country":1099,"countryCode":1100,"cosmosGeoPoint":1145,"geoPoint":1149,"contacts":35},"Centre d'Oftalmologia Barraquer \u002FID# 266631","Barcelona","08021",{"type":56,"coordinates":1146},[1147,1148],2.15899,41.38879,{"lat":1148,"lon":1147},{"facility":1151,"status":49,"city":1143,"state":35,"zip":1152,"country":1099,"countryCode":1100,"cosmosGeoPoint":1153,"geoPoint":1155,"contacts":35},"Institut Clínic d'Oftalmologia (ICOF). Hospital Clínic d'Oftalmologia. \u002FID# 263152","08028",{"type":56,"coordinates":1154},[1147,1148],{"lat":1148,"lon":1147},{"facility":1157,"status":49,"city":1143,"state":35,"zip":1158,"country":1099,"countryCode":1100,"cosmosGeoPoint":1159,"geoPoint":1161,"contacts":35},"Hospital Universitari Vall d Hebron \u002FID# 263301","08035",{"type":56,"coordinates":1160},[1147,1148],{"lat":1148,"lon":1147},{"facility":1163,"status":49,"city":1119,"state":35,"zip":1164,"country":1099,"countryCode":1100,"cosmosGeoPoint":1165,"geoPoint":1169,"contacts":35},"Hospital Universitario 12 de Octubre \u002FID# 263544","28041",{"type":56,"coordinates":1166},[1167,1168],-3.70256,40.4165,{"lat":1168,"lon":1167},{"facility":1171,"status":49,"city":1172,"state":35,"zip":1173,"country":1099,"countryCode":1100,"cosmosGeoPoint":1174,"geoPoint":1178,"contacts":35},"Hospital Universitari i Politecnic La Fe \u002FID# 263441","Valencia","46026",{"type":56,"coordinates":1175},[1176,1177],-0.37966,39.47391,{"lat":1177,"lon":1176},{"facility":1180,"status":49,"city":1181,"state":35,"zip":1182,"country":1099,"countryCode":1100,"cosmosGeoPoint":1183,"geoPoint":1187,"contacts":35},"Hospital Clinico Universitario Lozano Blesa \u002FID# 263158","Zaragoza","50009",{"type":56,"coordinates":1184},[1185,1186],-0.87734,41.65606,{"lat":1186,"lon":1185},{"facility":1189,"status":49,"city":1190,"state":1191,"zip":1192,"country":1193,"countryCode":1194,"cosmosGeoPoint":1195,"geoPoint":1199,"contacts":35},"Gloucestershire Royal Hospital \u002FID# 276072","Gloucester","Gloucestershire","GL1 3NN","United Kingdom","UK",{"type":56,"coordinates":1196},[1197,1198],-2.2431,51.86568,{"lat":1198,"lon":1197},{"facility":1201,"status":49,"city":1202,"state":1203,"zip":1204,"country":1193,"countryCode":1194,"cosmosGeoPoint":1205,"geoPoint":1209,"contacts":35},"Moorfields Eye Hospital \u002FID# 267227","London","Greater London","EC1V 2PD",{"type":56,"coordinates":1206},[1207,1208],-0.12574,51.50853,{"lat":1208,"lon":1207},{"facility":1211,"status":49,"city":1202,"state":1203,"zip":1212,"country":1193,"countryCode":1194,"cosmosGeoPoint":1213,"geoPoint":1215,"contacts":35},"The Retina Clinic London \u002FID# 266156","W1G 7LB",{"type":56,"coordinates":1214},[1207,1208],{"lat":1208,"lon":1207},{"facility":1217,"status":49,"city":1218,"state":1219,"zip":1220,"country":1193,"countryCode":1194,"cosmosGeoPoint":1221,"geoPoint":1225,"contacts":35},"Liverpool University Hospitals NHS Foundation Trust \u002FID# 265854","Liverpool","Merseyside","L9 7AL",{"type":56,"coordinates":1222},[1223,1224],-2.97794,53.41058,{"lat":1224,"lon":1223},{"facility":1227,"status":49,"city":1228,"state":35,"zip":1229,"country":1193,"countryCode":1194,"cosmosGeoPoint":1230,"geoPoint":1234,"contacts":35},"Bristol Eye Hospital \u002FID# 266155","Bristol","BS1 2LX",{"type":56,"coordinates":1231},[1232,1233],-2.59665,51.45523,{"lat":1233,"lon":1232},{"facility":1236,"status":49,"city":1237,"state":35,"zip":1238,"country":1193,"countryCode":1194,"cosmosGeoPoint":1239,"geoPoint":1243,"contacts":35},"Sunderland Royal Hospital \u002FID# 266664","Sunderland","SR4 7TN",{"type":56,"coordinates":1240},[1241,1242],-1.38222,54.90465,{"lat":1242,"lon":1241},{"type":1245,"investigatorFullName":35,"investigatorTitle":35,"investigatorAffiliation":35,"oldNameTitle":35,"oldOrganization":35},"SPONSOR","100593486",false,"NCT07007065","Study to Assess the Injection Burden, Adverse Events, Change in Disease Activity, and Long-Term Preservation of Visual Acuity of Surabgene Lomparvovec in Adult Participants With Neovascular Age-Related Macular Degeneration (nAMD)","A Randomized, Controlled, Partially Masked, Phase 3b Study to Assess the Injection Burden, Efficacy, Safety, and Long-Term Preservation of Visual Acuity of Surabgene Lomparvovec (ABBV-RGX-314) in a Real-World Context in Subjects With Neovascular Age-Related Macular Degeneration (nAMD)","Inclusion Criteria:\n\n* Pseudophakic (at least 12 weeks post cataract surgery at Screening Visit 1 \\[Week -6\\]) in the study eye.\n* Must have a diagnosis of choroidal neovascularization (CNV) secondary to age-related macular degeneration (AMD) in the study eye\n\n  --CNV lesion characteristics as assessed by the central reading center: lesion size needs to be less than 10-disc areas (typical disc area = 2.54 mm\\^2)\n* Must have received at least 2 intravitreal anti-vascular endothelial growth factor (VEGF) injections in the past 6 months in the study eye prior to Screening Visit 1 (Week -6) and have been responsive (determined by investigator)\n\nExclusion Criteria:\n\n* CNV or macular edema in the study eye that is secondary to any causes other than AMD\n* Study eye with nAMD diagnosed \\> 4 years from Screening Visit 1\n* Any retinal pigment epithelial detachment \\> 400 μm or any pigment epithelial detachment \\> 350 μm within the central subfield (central 1 mm) in the study eye at Screening Visit 1 (Week -6), as assessed by the central reading center.\n* Any subretinal hemorrhage in the study eye \\> 50% of the total lesion area or within the parafovea (3 mm center of the macula), as determined by the central reading center\n* Retinal pigment epithelial tear involving the central subfield (central 1 mm) in the study eye as determined by the central reading center.","ALL","50 Years",{"count":1255,"type":1256},561,"ESTIMATED","INTERVENTIONAL",[1259],"PHASE3","Neovascular age-related macular degeneration (nAMD), also known as \"wet\" AMD, is the abnormal growth of new blood vessels in the light-sensitive tissue at the back of the eye called the retina. The purpose of this study is to assess how safe and effective Surabgene Lomparvovec is in treating participants with Neovascular age-related macular degeneration (nAMD).\n\nSurabgene Lomparvovec (ABBV-RGX-314) is an investigational gene therapy being developed for the treatment of neovascular age-related macular degeneration (nAMD). Participants will be placed into 1 of 3 groups, called treatment arms. Each group receives different treatment. Adult participants aged 50 and older years with a diagnosis of previously treated nAMD will be enrolled. Around 561 participants will be enrolled in the study at approximately 150 sites worldwide.\n\nParticipants in groups 1 and 2 will receive a single subretinal dose of ABBV-RGX-314. Participants in group 3 will receive Ranibizumab as needed throughout the study. Ranibizumab will be given as an intravitreal injection (injection into the jelly-like tissue that fills the eyeball injection), and ABBV-RGX-314 will be given as a subretinal (between the retina and the back of the eye) injection. The Assessment Period begins after randomization (1:1:1) to one of the ABBV-RGX-314 treatment groups or control at Week -2 and lasts up to 5 years.\n\nThere may be higher treatment burden for participants in this trial compared to their standard of care. Participants will attend regular monthly visits during the study at a hospital or clinic. The effect of the treatment will be checked by medical assessments, blood tests, checking for side effects and completing questionnaires.",[1262],"Neovascular Age-related Macular Degeneration",[1264,30,1265],"Neovascular age-related macular degeneration","ABBV-RGX-314","2026-06-25",{"date":1268,"type":1269},"2026-06-29","ACTUAL",{"date":1271,"type":1269},"2025-11-05",{"date":1273,"type":1256},"2033-03",{"name":5,"class":6},127]